CRCGN017_MCF10A.TP53.M_24H:C03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-diindolylmethane 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

19 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.8285
DENND2D DENN/MADD domain containing 2D 2.5724
PLEKHJ1 pleckstrin homology domain containing, family J member 1 2.4674
MELK maternal embryonic leucine zipper kinase 2.04805

decreased expression

Symbol Name Standardized Value
HAT1 histone acetyltransferase 1 -6.01845
LAP3 leucine aminopeptidase 3 -4.72735
GRWD1 glutamate-rich WD repeat containing 1 -4.06095
ATF5 activating transcription factor 5 -3.2488
HOXA5 homeobox A5 -3.1895
NR2F6 nuclear receptor subfamily 2, group F, member 6 -3.15158
STMN1 stathmin 1 -3.13285
RGS2 regulator of G-protein signaling 2 -2.67095
RALGDS ral guanine nucleotide dissociation stimulator -2.54313
REEP5 receptor accessory protein 5 -2.29485
CYBRD1 cytochrome b reductase 1 -2.15165
TEAD4 TEA domain family member 4 -2.06565
RAD51C RAD51 paralog C -2.0476
LHX6 LIM homeobox 6 -2.04465
SLC25A12 solute carrier family 25 (aspartate/glutamate carrier), member 12 -2.02737