CRCGN017_MCF10A.TP53.M_24H:C04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description leflunomide 100.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 5.11948
SPAG4 sperm associated antigen 4 4.54332
HMGA2 high mobility group AT-hook 2 4.06614
IL1B interleukin 1, beta 3.80943
TRIB1 tribbles pseudokinase 1 3.73943
SRC SRC proto-oncogene, non-receptor tyrosine kinase 3.36632
DUSP6 dual specificity phosphatase 6 3.35959
AGR2 anterior gradient 2 3.2134
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.03738
RBP4 retinol binding protein 4, plasma 2.95604
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.95281
PPARG peroxisome proliferator-activated receptor gamma 2.89448
FHL2 four and a half LIM domains 2 2.78946
EGR1 early growth response 1 2.70773
ACADVL acyl-CoA dehydrogenase, very long chain 2.61349
COMP cartilage oligomeric matrix protein 2.58839
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.57829
LIF leukemia inhibitory factor 2.54466
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 2.47558
FOSL1 FOS-like antigen 1 2.47064
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.4367
DUSP4 dual specificity phosphatase 4 2.41373
CCL20 chemokine (C-C motif) ligand 20 2.39985
NT5E 5'-nucleotidase, ecto (CD73) 2.39734
CHIC2 cysteine-rich hydrophobic domain 2 2.38846
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.29796
EGR3 early growth response 3 2.29613
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.26985
IER3 immediate early response 3 2.26968
NRIP1 nuclear receptor interacting protein 1 2.26711
IL1A interleukin 1, alpha 2.25249
GAS2 growth arrest-specific 2 2.25138
INPP1 inositol polyphosphate-1-phosphatase 2.23662
RAB38 RAB38, member RAS oncogene family 2.23185
FAH fumarylacetoacetate hydrolase (fumarylacetoacetase) 2.22439
IFNGR2 interferon gamma receptor 2 (interferon gamma transducer 1) 2.09466
TLCD3A TLC domain containing 3A 2.06693
GALE UDP-galactose-4-epimerase 2.06568
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.0643
HOMER1 homer scaffolding protein 1 2.0598
EPS8 epidermal growth factor receptor pathway substrate 8 2.04121
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.03331
PNKP polynucleotide kinase 3'-phosphatase 2.02152

decreased expression

Symbol Name Standardized Value
COG2 component of oligomeric golgi complex 2 -6.59491
PRR15L proline rich 15-like -3.68348
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -3.39187
ATF5 activating transcription factor 5 -3.22656
ADRB2 adrenoceptor beta 2, surface -2.93964
TCEA2 transcription elongation factor A (SII), 2 -2.87792
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.77283
GADD45B growth arrest and DNA-damage-inducible, beta -2.76465
HSPA1A heat shock 70kDa protein 1A -2.7215
TICAM1 toll-like receptor adaptor molecule 1 -2.66067
SNX15 sorting nexin 15 -2.57481
TTC13 tetratricopeptide repeat domain 13 -2.52728
DSG2 desmoglein 2 -2.45313
GRWD1 glutamate-rich WD repeat containing 1 -2.40861
DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1) -2.39227
STMN1 stathmin 1 -2.34877
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.3054
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.27014
VPS33A vacuolar protein sorting 33 homolog A (S. cerevisiae) -2.26627
ZDHHC6 zinc finger, DHHC-type containing 6 -2.26491
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.2423
SERF1A small EDRK-rich factor 1A (telomeric) -2.22664
MVD mevalonate (diphospho) decarboxylase -2.22035
BRF2 BRF2, RNA polymerase III transcription initiation factor 50 kDa subunit -2.16181
CGRRF1 cell growth regulator with ring finger domain 1 -2.08295
SNRNP25 small nuclear ribonucleoprotein 25kDa (U11/U12) -2.06871
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.06511
GLOD4 glyoxalase domain containing 4 -2.0463
TTC1 tetratricopeptide repeat domain 1 -2.02282
BAG1 BCL2-associated athanogene -2.02231
DCTPP1 dCTP pyrophosphatase 1 -2.00239