CRCGN017_MCF10A.TP53.M_24H:C05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description leflunomide 33.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

30 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.70735
COMP cartilage oligomeric matrix protein 3.40255
LGMN legumain 3.0355
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 2.92121
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.72005
TUT7 terminal uridylyl transferase 7 2.65161
CBR4 carbonyl reductase 4 2.40661
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.29907
TNFRSF6B tumor necrosis factor receptor superfamily, member 6b, decoy 2.28823
SKIC2 SKI2 subunit of superkiller complex 2.27777
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.25051
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 2.19339
LYRM1 LYR motif containing 1 2.02503
NIT1 nitrilase 1 2.00272

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -5.27655
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.15006
THAP11 THAP domain containing 11 -2.72772
NAPG N-ethylmaleimide-sensitive factor attachment protein, gamma -2.67193
CDK4 cyclin-dependent kinase 4 -2.56928
RBBP9 retinoblastoma binding protein 9 -2.4217
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.40667
KDM3A lysine (K)-specific demethylase 3A -2.27756
STMN1 stathmin 1 -2.26313
IKZF5 IKAROS family zinc finger 5 (Pegasus) -2.25265
CRYZ crystallin, zeta (quinone reductase) -2.24142
SGCB sarcoglycan, beta (43kDa dystrophin-associated glycoprotein) -2.10647
CDK2 cyclin-dependent kinase 2 -2.10176
VAT1 vesicle amine transport 1 -2.03354
ASB7 ankyrin repeat and SOCS box containing 7 -2.00804
KMT5A lysine methyltransferase 5A -2.00387