CRCGN017_MCF10A.TP53.M_24H:C06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description leflunomide 11.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

149 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 8.69429
PHKA1 phosphorylase kinase, alpha 1 (muscle) 5.89925
SNAP25 synaptosomal-associated protein, 25kDa 5.24823
SPAG4 sperm associated antigen 4 5.18782
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 4.86955
PLCB3 phospholipase C, beta 3 (phosphatidylinositol-specific) 4.71608
HMOX1 heme oxygenase 1 3.97537
REEP2 receptor accessory protein 2 3.49512
NSG2 neuronal vesicle trafficking associated 2 3.40418
EMC9 ER membrane protein complex subunit 9 2.8671
ZFPM1 zinc finger protein, FOG family member 1 2.83449
TUT1 terminal uridylyl transferase 1, U6 snRNA-specific 2.80948
NMNAT2 nicotinamide nucleotide adenylyltransferase 2 2.72898
ACBD4 acyl-CoA binding domain containing 4 2.68214
INA internexin neuronal intermediate filament protein, alpha 2.63107
EVC Ellis van Creveld protein 2.60154
ABCF3 ATP-binding cassette, sub-family F (GCN20), member 3 2.58129
FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase) 2.55782
COMP cartilage oligomeric matrix protein 2.48076
CNTFR ciliary neurotrophic factor receptor 2.47259
FNDC4 fibronectin type III domain containing 4 2.45405
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F 2.45367
PSMB9 proteasome (prosome, macropain) subunit, beta type, 9 2.42235
CD2BP2 CD2 (cytoplasmic tail) binding protein 2 2.39756
TARBP2 TAR (HIV-1) RNA binding protein 2 2.3763
ARHGEF5 Rho guanine nucleotide exchange factor (GEF) 5 2.34857
DBH dopamine beta-hydroxylase (dopamine beta-monooxygenase) 2.32844
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.28466
PRDM12 PR domain containing 12 2.28364
MYOD1 myogenic differentiation 1 2.26983
NOC2L nucleolar complex associated 2 homolog (S. cerevisiae) 2.25055
SLC6A11 solute carrier family 6 (neurotransmitter transporter), member 11 2.2456
KCNF1 potassium channel, voltage gated modifier subfamily F, member 1 2.23614
ADAMTS13 ADAM metallopeptidase with thrombospondin type 1 motif, 13 2.23331
EIF2B4 eukaryotic translation initiation factor 2B, subunit 4 delta, 67kDa 2.22981
SNAP91 synaptosomal-associated protein, 91kDa 2.22931
MORN1 MORN repeat containing 1 2.22615
SRPK3 SRSF protein kinase 3 2.20426
RUNDC3A RUN domain containing 3A 2.20418
TSPYL2 TSPY-like 2 2.20314
WDR7 WD repeat domain 7 2.20212
KIAA0513 KIAA0513 2.20107
ZSCAN2 zinc finger and SCAN domain containing 2 2.19902
NEFM neurofilament, medium polypeptide 2.19076
DUSP28 dual specificity phosphatase 28 2.17611
C2CD5 C2 calcium-dependent domain containing 5 2.16694
ACTL6B actin-like 6B 2.16409
AMBRA1 autophagy/beclin-1 regulator 1 2.15967
HS3ST3A1 heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1 2.15903
SLC26A1 solute carrier family 26 (anion exchanger), member 1 2.15301
NGB neuroglobin 2.14956
RDH16 retinol dehydrogenase 16 (all-trans) 2.14789
PADI1 peptidyl arginine deiminase, type I 2.14512
GAD1 glutamate decarboxylase 1 (brain, 67kDa) 2.14399
GSTT2B glutathione S-transferase theta 2B (gene/pseudogene) 2.14204
CHRNG cholinergic receptor, nicotinic, gamma (muscle) 2.1417
PSPN persephin 2.13502
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.13499
FRRS1L ferric-chelate reductase 1-like 2.12519
MAP3K10 mitogen-activated protein kinase kinase kinase 10 2.12309
RSBN1 round spermatid basic protein 1 2.12035
STN1 STN1 subunit of CST complex 2.11603
TCEAL1 transcription elongation factor A (SII)-like 1 2.11243
CACNA1S calcium channel, voltage-dependent, L type, alpha 1S subunit 2.10883
PDCD1 programmed cell death 1 2.10445
MBD1 methyl-CpG binding domain protein 1 2.10176
TAGLN3 transgelin 3 2.10171
SNCA synuclein, alpha (non A4 component of amyloid precursor) 2.10117
SYP synaptophysin 2.09397
COL17A1 collagen, type XVII, alpha 1 2.09244
CHRNB2 cholinergic receptor, nicotinic, beta 2 (neuronal) 2.08512
ADGRB1 adhesion G protein-coupled receptor B1 2.08456
RGS4 regulator of G-protein signaling 4 2.08105
MRM1 mitochondrial rRNA methyltransferase 1 homolog (S. cerevisiae) 2.0774
BEX2 brain expressed X-linked 2 2.07534
TRIM8 tripartite motif containing 8 2.07036
CYP2W1 cytochrome P450, family 2, subfamily W, polypeptide 1 2.06996
ARMC7 armadillo repeat containing 7 2.06893
LOC128125814 uncharacterized LOC128125814 2.06542
PHYHIP phytanoyl-CoA 2-hydroxylase interacting protein 2.05358
POLL polymerase (DNA directed), lambda 2.05326
MCRS1 microspherule protein 1 2.05103
SCG3 secretogranin III 2.04881
NELL1 NEL-like 1 (chicken) 2.0425
NLRP4 NLR family, pyrin domain containing 4 2.04216
NAXD NAD(P)HX dehydratase 2.03663
SGF29 SAGA complex associated factor 29 2.02577
UBA7 ubiquitin-like modifier activating enzyme 7 2.02432
DERA deoxyribose-phosphate aldolase (putative) 2.02334
SPRED2 sprouty-related, EVH1 domain containing 2 2.00595
GNL1 guanine nucleotide binding protein-like 1 2.00137
ZNF419 zinc finger protein 419 2.00089
CDCA4 cell division cycle associated 4 2.00062

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -9.55725
PRPF4 pre-mRNA processing factor 4 -5.25381
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -5.10707
FASTKD5 FAST kinase domains 5 -5.045
PCNA proliferating cell nuclear antigen -4.84845
SLC35F2 solute carrier family 35, member F2 -4.66002
UBE3C ubiquitin protein ligase E3C -4.11819
MSN moesin -3.42293
FKBP1C FK506 binding protein 1C -3.21462
TMEM230 transmembrane protein 230 -3.03004
IDH3B isocitrate dehydrogenase 3 (NAD+) beta -2.84199
MFSD12 major facilitator superfamily domain containing 12 -2.80334
THAP11 THAP domain containing 11 -2.7006
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.69616
COTL1 coactosin-like F-actin binding protein 1 -2.60707
VAT1 vesicle amine transport 1 -2.54589
DDRGK1 DDRGK domain containing 1 -2.50628
CSNK2A2 casein kinase 2, alpha prime polypeptide -2.47869
FKBP1A FK506 binding protein 1A, 12kDa -2.46076
NAA35 N(alpha)-acetyltransferase 35, NatC auxiliary subunit -2.44889
SNRPB small nuclear ribonucleoprotein polypeptides B and B1 -2.44064
RASSF2 Ras association (RalGDS/AF-6) domain family member 2 -2.4079
ATP6V1G1 ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G1 -2.37313
KMT5A lysine methyltransferase 5A -2.3209
TPM4 tropomyosin 4 -2.31723
NSFL1C NSFL1 (p97) cofactor (p47) -2.31513
CAB39 calcium binding protein 39 -2.30198
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -2.30027
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.29851
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.28512
IMPA2 inositol(myo)-1(or 4)-monophosphatase 2 -2.25752
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.24864
GNA13 guanine nucleotide binding protein (G protein), alpha 13 -2.24451
MAP2K2 mitogen-activated protein kinase kinase 2 -2.23969
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.22621
NES nestin -2.20887
PSMB7 proteasome (prosome, macropain) subunit, beta type, 7 -2.19026
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) -2.18502
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.17772
AGTPBP1 ATP/GTP binding protein 1 -2.16357
AGPS alkylglycerone phosphate synthase -2.15113
TNNC1 troponin C type 1 (slow) -2.12146
NCK2 NCK adaptor protein 2 -2.1121
OXA1L oxidase (cytochrome c) assembly 1-like -2.1074
NOP56 NOP56 ribonucleoprotein -2.10726
KRT14 keratin 14, type I -2.1029
BSPRY B-box and SPRY domain containing -2.09657
ABHD17B abhydrolase domain containing 17B -2.08173
CHST11 carbohydrate (chondroitin 4) sulfotransferase 11 -2.08034
SLC17A9 solute carrier family 17 (vesicular nucleotide transporter), member 9 -2.07786
DSG2 desmoglein 2 -2.06809
CAPNS1 calpain, small subunit 1 -2.03915
CDK6 cyclin-dependent kinase 6 -2.03135
RNF220 ring finger protein 220 -2.02223
GATM glycine amidinotransferase (L-arginine:glycine amidinotransferase) -2.01638
SNX24 sorting nexin 24 -2.01631