| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | sr1664 10.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
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115 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C07 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AGR2 | anterior gradient 2 | 6.18205 |
| ADO | 2-aminoethanethiol (cysteamine) dioxygenase | 5.8181 |
| KCTD5 | potassium channel tetramerization domain containing 5 | 5.2713 |
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 5.01155 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 4.9204 |
| NFKBIE | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 4.7728 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 4.6018 |
| PHGDH | phosphoglycerate dehydrogenase | 4.0685 |
| FGFR4 | fibroblast growth factor receptor 4 | 3.9082 |
| AARS1 | alanyl-tRNA synthetase 1 | 3.8116 |
| IKBKE | inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon | 3.73882 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 3.38618 |
| AZIN2 | antizyme inhibitor 2 | 3.36165 |
| OXCT1 | 3-oxoacid CoA transferase 1 | 3.05835 |
| TRIB3 | tribbles pseudokinase 3 | 3.05635 |
| ALAS1 | 5'-aminolevulinate synthase 1 | 2.9936 |
| CETN3 | centrin, EF-hand protein, 3 | 2.8979 |
| XPOT | exportin, tRNA | 2.8961 |
| EIF4EBP1 | eukaryotic translation initiation factor 4E binding protein 1 | 2.89585 |
| NRBF2 | nuclear receptor binding factor 2 | 2.83955 |
| SATB1 | SATB homeobox 1 | 2.82075 |
| GPATCH8 | G patch domain containing 8 | 2.81055 |
| PRKX | protein kinase, X-linked | 2.74275 |
| CSTF2T | cleavage stimulation factor, 3' pre-RNA, subunit 2, 64kDa, tau variant | 2.71685 |
| PSAT1 | phosphoserine aminotransferase 1 | 2.68015 |
| GCA | grancalcin, EF-hand calcium binding protein | 2.6709 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 2.5344 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 2.47085 |
| TAF7 | TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa | 2.4002 |
| KRR1 | KRR1, small subunit (SSU) processome component, homolog (yeast) | 2.38705 |
| MARS1 | methionyl-tRNA synthetase 1 | 2.3547 |
| HMG20A | high mobility group 20A | 2.3424 |
| CMAS | cytidine monophosphate N-acetylneuraminic acid synthetase | 2.29255 |
| YEATS4 | YEATS domain containing 4 | 2.26475 |
| YARS1 | tyrosyl-tRNA synthetase 1 | 2.2368 |
| TARS1 | threonyl-tRNA synthetase 1 | 2.22135 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.2155 |
| CCL24 | chemokine (C-C motif) ligand 24 | 2.20945 |
| BCOR | BCL6 corepressor | 2.20815 |
| DHRS4 | dehydrogenase/reductase (SDR family) member 4 | 2.18895 |
| GARS1 | glycyl-tRNA synthetase 1 | 2.18305 |
| IL2RG | interleukin 2 receptor, gamma | 2.14865 |
| ZEB2 | zinc finger E-box binding homeobox 2 | 2.14755 |
| SLC30A9 | solute carrier family 30 (zinc transporter), member 9 | 2.1451 |
| TTC33 | tetratricopeptide repeat domain 33 | 2.14415 |
| ZNF410 | zinc finger protein 410 | 2.14287 |
| TOMM34 | translocase of outer mitochondrial membrane 34 | 2.13115 |
| SARS1 | seryl-tRNA synthetase 1 | 2.11145 |
| TMEM267 | transmembrane protein 267 | 2.06885 |
| DDIT4 | DNA-damage-inducible transcript 4 | 2.0635 |
| NAP1L3 | nucleosome assembly protein 1-like 3 | 2.06225 |
| PARG | poly (ADP-ribose) glycohydrolase | 2.025 |
| FAM114A2 | family with sequence similarity 114, member A2 | 2.0213 |
| PRR16 | proline rich 16 | 2.0137 |
| Symbol | Name | Standardized Value |
|---|---|---|
| PLK1 | polo-like kinase 1 | -5.53985 |
| TARBP1 | TAR (HIV-1) RNA binding protein 1 | -5.0 |
| RPIA | ribose 5-phosphate isomerase A | -4.9815 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.85945 |
| KRT14 | keratin 14, type I | -4.84925 |
| PCNA | proliferating cell nuclear antigen | -4.66275 |
| HEATR1 | HEAT repeat containing 1 | -4.42998 |
| CRK | v-crk avian sarcoma virus CT10 oncogene homolog | -3.79195 |
| KLK5 | kallikrein-related peptidase 5 | -3.23075 |
| SNX5 | sorting nexin 5 | -3.0725 |
| BFAR | bifunctional apoptosis regulator | -2.7748 |
| TKT | transketolase | -2.71012 |
| SNRPB2 | small nuclear ribonucleoprotein polypeptide B | -2.6901 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | -2.6666 |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | -2.56248 |
| ZNF589 | zinc finger protein 589 | -2.52095 |
| ATXN2 | ataxin 2 | -2.4815 |
| ANKRD10 | ankyrin repeat domain 10 | -2.4645 |
| UNC119 | unc-119 homolog (C. elegans) | -2.4227 |
| TFCP2L1 | transcription factor CP2-like 1 | -2.40475 |
| AKR1C3 | aldo-keto reductase family 1, member C3 | -2.3954 |
| TLK2 | tousled-like kinase 2 | -2.38452 |
| YWHAE | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon | -2.38145 |
| IPO13 | importin 13 | -2.36775 |
| AUP1 | ancient ubiquitous protein 1 | -2.34985 |
| TMEM59L | transmembrane protein 59-like | -2.32995 |
| SNPH | syntaphilin | -2.2919 |
| SCN1B | sodium channel, voltage gated, type I beta subunit | -2.275 |
| EPHX1 | epoxide hydrolase 1, microsomal (xenobiotic) | -2.26505 |
| STARD7 | StAR-related lipid transfer (START) domain containing 7 | -2.264 |
| VPS35L | VPS35 endosomal protein sorting factor like | -2.24345 |
| PRRX2 | paired related homeobox 2 | -2.23 |
| DPF1 | D4, zinc and double PHD fingers family 1 | -2.22855 |
| APMAP | adipocyte plasma membrane associated protein | -2.2219 |
| NSFL1C | NSFL1 (p97) cofactor (p47) | -2.20817 |
| GINS1 | GINS complex subunit 1 (Psf1 homolog) | -2.20445 |
| ARMCX2 | armadillo repeat containing, X-linked 2 | -2.20385 |
| ALOX15B | arachidonate 15-lipoxygenase, type B | -2.20365 |
| BCAS4 | breast carcinoma amplified sequence 4 | -2.197 |
| FOLR3 | folate receptor 3 (gamma) | -2.17525 |
| ESF1 | ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) | -2.17425 |
| MAVS | mitochondrial antiviral signaling protein | -2.1591 |
| AP5S1 | adaptor-related protein complex 5, sigma 1 subunit | -2.15125 |
| NOP56 | NOP56 ribonucleoprotein | -2.15095 |
| UBAP2 | ubiquitin associated protein 2 | -2.1398 |
| SLC17A5 | solute carrier family 17 (acidic sugar transporter), member 5 | -2.1333 |
| TESPA1 | thymocyte expressed, positive selection associated 1 | -2.0932 |
| GSTP1 | glutathione S-transferase pi 1 | -2.09155 |
| MT1E | metallothionein 1E | -2.08615 |
| CCNC | cyclin C | -2.08395 |
| PGM5 | phosphoglucomutase 5 | -2.0797 |
| GATC | glutamyl-tRNA(Gln) amidotransferase, subunit C | -2.07725 |
| MRNIP | MRN complex interacting protein | -2.066 |
| DDRGK1 | DDRGK domain containing 1 | -2.06285 |
| CLDN11 | claudin 11 | -2.05825 |
| NRN1 | neuritin 1 | -2.05395 |
| KANK1 | KN motif and ankyrin repeat domains 1 | -2.0474 |
| AKR1C1 | aldo-keto reductase family 1, member C1 | -2.03899 |
| MT1M | metallothionein 1M | -2.0293 |
| EGLN1 | egl-9 family hypoxia-inducible factor 1 | -2.00675 |
| MPHOSPH8 | M-phase phosphoprotein 8 | -2.00495 |
