CRCGN017_MCF10A.TP53.M_24H:C08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sr1664 3.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

40 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 4.16617
SSBP2 single-stranded DNA binding protein 2 3.7494
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.72622
GPER1 G protein-coupled estrogen receptor 1 3.67157
CHEK1 checkpoint kinase 1 3.3721
CNRIP1 cannabinoid receptor interacting protein 1 3.22757
MINDY1 MINDY lysine 48 deubiquitinase 1 3.16494
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 2.66252
MYLK myosin light chain kinase 2.46219
B4GAT1 beta-1,4-glucuronyltransferase 1 2.40114
LRP10 low density lipoprotein receptor-related protein 10 2.32431
NUCB2 nucleobindin 2 2.2159
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.06078

decreased expression

Symbol Name Standardized Value
CIAPIN1 cytokine induced apoptosis inhibitor 1 -4.32683
COG2 component of oligomeric golgi complex 2 -4.27978
ACOT9 acyl-CoA thioesterase 9 -4.01222
TUBA4A tubulin, alpha 4a -3.70581
RGS2 regulator of G-protein signaling 2 -2.96881
ATF5 activating transcription factor 5 -2.86021
TXNL4B thioredoxin-like 4B -2.68275
HSPA1A heat shock 70kDa protein 1A -2.60141
GRWD1 glutamate-rich WD repeat containing 1 -2.57626
HMG20B high mobility group 20B -2.52102
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) -2.48197
KDM3A lysine (K)-specific demethylase 3A -2.47325
CDC25B cell division cycle 25B -2.394
CANT1 calcium activated nucleotidase 1 -2.34736
SLC61A1 solute carrier family 61 member 1 -2.32227
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.26129
STIMATE STIM activating enhancer -2.20684
LOC124905743 low affinity immunoglobulin gamma Fc region receptor III-B -2.14782
MYOM2 myomesin 2 -2.13971
SRGN serglycin -2.11668
YIPF1 Yip1 domain family, member 1 -2.05961
HSPBAP1 HSPB (heat shock 27kDa) associated protein 1 -2.05699
SERF1A small EDRK-rich factor 1A (telomeric) -2.03992
RPAP2 RNA polymerase II associated protein 2 -2.03138
RUNX3 runt-related transcription factor 3 -2.01611
CA8 carbonic anhydrase VIII -2.01007
THAP12 THAP domain containing 12 -2.00569