| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | lg100268 10.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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88 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| MTHFD2 | methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase | 5.14911 |
| CASP2 | caspase 2, apoptosis-related cysteine peptidase | 4.05854 |
| RBP4 | retinol binding protein 4, plasma | 3.44362 |
| PCK2 | phosphoenolpyruvate carboxykinase 2 (mitochondrial) | 3.39234 |
| TRIB3 | tribbles pseudokinase 3 | 3.33544 |
| GRB10 | growth factor receptor-bound protein 10 | 3.23671 |
| SSR3 | signal sequence receptor, gamma (translocon-associated protein gamma) | 3.1964 |
| AARS1 | alanyl-tRNA synthetase 1 | 3.18178 |
| PHGDH | phosphoglycerate dehydrogenase | 3.15355 |
| ASNS | asparagine synthetase (glutamine-hydrolyzing) | 3.10634 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.01795 |
| NR3C1 | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | 3.00331 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 2.99888 |
| FHL2 | four and a half LIM domains 2 | 2.93716 |
| IL1B | interleukin 1, beta | 2.7184 |
| ATF4 | activating transcription factor 4 | 2.68203 |
| GARS1 | glycyl-tRNA synthetase 1 | 2.67867 |
| PYCR1 | pyrroline-5-carboxylate reductase 1 | 2.63392 |
| SHMT2 | serine hydroxymethyltransferase 2 (mitochondrial) | 2.52824 |
| CARS1 | cysteinyl-tRNA synthetase 1 | 2.46885 |
| CHAC1 | ChaC glutathione-specific gamma-glutamylcyclotransferase 1 | 2.40408 |
| SLC1A4 | solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 | 2.38105 |
| PSAT1 | phosphoserine aminotransferase 1 | 2.36267 |
| STT3A | STT3A, subunit of the oligosaccharyltransferase complex (catalytic) | 2.34349 |
| EIF2S3 | eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa | 2.34193 |
| PRR3 | proline rich 3 | 2.33429 |
| TBC1D16 | TBC1 domain family, member 16 | 2.32046 |
| MMP1 | matrix metallopeptidase 1 | 2.28883 |
| TIAM1 | T-cell lymphoma invasion and metastasis 1 | 2.25486 |
| HMGA2 | high mobility group AT-hook 2 | 2.21728 |
| PRPF39 | pre-mRNA processing factor 39 | 2.20174 |
| ACAA1 | acetyl-CoA acyltransferase 1 | 2.18091 |
| XPOT | exportin, tRNA | 2.17727 |
| MTA2 | metastasis associated 1 family, member 2 | 2.17205 |
| NUCB2 | nucleobindin 2 | 2.16051 |
| FOS | FBJ murine osteosarcoma viral oncogene homolog | 2.1576 |
| CAPRIN2 | caprin family member 2 | 2.15674 |
| CWF19L1 | CWF19-like 1, cell cycle control (S. pombe) | 2.1234 |
| SMU1 | smu-1 suppressor of mec-8 and unc-52 homolog (C. elegans) | 2.11079 |
| EGR1 | early growth response 1 | 2.10555 |
| STX1A | syntaxin 1A (brain) | 2.08519 |
| RBBP5 | retinoblastoma binding protein 5 | 2.05774 |
| PKIG | protein kinase (cAMP-dependent, catalytic) inhibitor gamma | 2.05156 |
| SLC22A3 | solute carrier family 22 (organic cation transporter), member 3 | 2.04872 |
| GNA15 | guanine nucleotide binding protein (G protein), alpha 15 (Gq class) | 2.04256 |
| ADSL | adenylosuccinate lyase | 2.04097 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HOXA5 | homeobox A5 | -4.01358 |
| RGS2 | regulator of G-protein signaling 2 | -3.81701 |
| ATF5 | activating transcription factor 5 | -3.7946 |
| HAT1 | histone acetyltransferase 1 | -3.59874 |
| DNAJB1 | DnaJ (Hsp40) homolog, subfamily B, member 1 | -3.55262 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -3.54688 |
| TRAPPC3 | trafficking protein particle complex 3 | -3.47631 |
| ADRB2 | adrenoceptor beta 2, surface | -3.45136 |
| SCYL3 | SCY1-like 3 (S. cerevisiae) | -3.28657 |
| PRR15L | proline rich 15-like | -3.12199 |
| SLC5A6 | solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 | -3.11445 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -3.09001 |
| NR2F6 | nuclear receptor subfamily 2, group F, member 6 | -2.97346 |
| CD320 | CD320 molecule | -2.71873 |
| MRPL34 | mitochondrial ribosomal protein L34 | -2.57173 |
| TUBA4A | tubulin, alpha 4a | -2.54486 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -2.50439 |
| DDX6 | DEAD (Asp-Glu-Ala-Asp) box helicase 6 | -2.42463 |
| LLGL2 | lethal giant larvae homolog 2 (Drosophila) | -2.38562 |
| MSMO1 | methylsterol monooxygenase 1 | -2.36497 |
| BLCAP | bladder cancer associated protein | -2.32697 |
| S100A4 | S100 calcium binding protein A4 | -2.32108 |
| CLDN4 | claudin 4 | -2.31494 |
| HEXIM1 | hexamethylene bis-acetamide inducible 1 | -2.30096 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -2.29745 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -2.2933 |
| OCEL1 | occludin/ELL domain containing 1 | -2.27601 |
| PSMD3 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 3 | -2.25858 |
| RAB11FIP1 | RAB11 family interacting protein 1 (class I) | -2.19605 |
| ABHD4 | abhydrolase domain containing 4 | -2.15008 |
| BABAM1 | BRISC and BRCA1 A complex member 1 | -2.13267 |
| MGRN1 | mahogunin ring finger 1, E3 ubiquitin protein ligase | -2.11616 |
| CDR2L | cerebellar degeneration-related protein 2-like | -2.10863 |
| HMGCR | 3-hydroxy-3-methylglutaryl-CoA reductase | -2.09767 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -2.06559 |
| KXD1 | KxDL motif containing 1 | -2.05761 |
| MAPK3 | mitogen-activated protein kinase 3 | -2.04962 |
| PLEKHM2 | pleckstrin homology domain containing, family M (with RUN domain) member 2 | -2.04492 |
| VAMP8 | vesicle-associated membrane protein 8 | -2.03503 |
| RLF | rearranged L-myc fusion | -2.01921 |
| MAP7D1 | MAP7 domain containing 1 | -2.00642 |
| CDK20 | cyclin-dependent kinase 20 | -2.00387 |
