CRCGN017_MCF10A.TP53.M_24H:C13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bexarotene 1.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

87 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TCEA2 transcription elongation factor A (SII), 2 4.97409
CASP2 caspase 2, apoptosis-related cysteine peptidase 4.80935
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 4.0598
COMP cartilage oligomeric matrix protein 3.93641
E2F2 E2F transcription factor 2 3.92433
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.8625
ZNF589 zinc finger protein 589 3.56787
AGR2 anterior gradient 2 3.5223
STK10 serine/threonine kinase 10 3.36546
SNAP25 synaptosomal-associated protein, 25kDa 3.29753
CRHBP corticotropin releasing hormone binding protein 2.84745
PKN1 protein kinase N1 2.73297
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 2.72611
IL12A interleukin 12A 2.67805
RRS1 RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) 2.65607
NME8 NME/NM23 family member 8 2.58198
CCL23 chemokine (C-C motif) ligand 23 2.54312
RSF1 remodeling and spacing factor 1 2.53397
ADRB2 adrenoceptor beta 2, surface 2.50539
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.50133
LSP1 lymphocyte-specific protein 1 2.4994
MCUR1 mitochondrial calcium uniporter regulator 1 2.4831
CD244 CD244 molecule, natural killer cell receptor 2B4 2.46175
BAG4 BCL2-associated athanogene 4 2.44793
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.42537
FCHO1 FCH domain only 1 2.36358
DEFB126 defensin, beta 126 2.32621
GPR173 G protein-coupled receptor 173 2.30099
MDM4 MDM4, p53 regulator 2.29717
ATP8B4 ATPase, class I, type 8B, member 4 2.29709
SLC75A1 solute carrier family 75 member 1 2.28903
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.28494
LILRA5 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 5 2.27666
SMG1 SMG1 phosphatidylinositol 3-kinase-related kinase 2.25556
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.25349
WDR76 WD repeat domain 76 2.25171
STAT2 signal transducer and activator of transcription 2, 113kDa 2.24624
FAM110B family with sequence similarity 110, member B 2.23088
STK26 serine/threonine protein kinase 26 2.22086
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.16807
LILRA1 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 1 2.16791
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.15975
OSTF1 osteoclast stimulating factor 1 2.13488
STRN3 striatin, calmodulin binding protein 3 2.12765
LRIG2 leucine-rich repeats and immunoglobulin-like domains 2 2.10691
GINS4 GINS complex subunit 4 (Sld5 homolog) 2.08885
ZYX zyxin 2.08315
OPN1SW opsin 1 (cone pigments), short-wave-sensitive 2.08065
DBF4B DBF4 zinc finger B 2.07887
ADAM7 ADAM metallopeptidase domain 7 2.06221
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 2.04687
EFHD2 EF-hand domain family, member D2 2.04536
DDX51 DEAD (Asp-Glu-Ala-Asp) box polypeptide 51 2.03861
MAP3K1 mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase 2.03803
HAUS3 HAUS augmin-like complex, subunit 3 2.03034
POLD3 polymerase (DNA-directed), delta 3, accessory subunit 2.03004
AGRP agouti related neuropeptide 2.02588
LSM12 LSM12 homolog (S. cerevisiae) 2.0186
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.01525
TCL1B T-cell leukemia/lymphoma 1B 2.01447
NAALADL1 N-acetylated alpha-linked acidic dipeptidase-like 1 2.00577
SNRNP40 small nuclear ribonucleoprotein 40kDa (U5) 2.00149
INCENP inner centromere protein antigens 135/155kDa 2.00124

decreased expression

Symbol Name Standardized Value
NGRN neugrin, neurite outgrowth associated -4.48097
COG2 component of oligomeric golgi complex 2 -3.93375
CCNB2 cyclin B2 -3.45038
KIF20A kinesin family member 20A -3.42938
PUF60 poly-U binding splicing factor 60KDa -3.37936
KDM3A lysine (K)-specific demethylase 3A -3.09358
CORO1A coronin, actin binding protein, 1A -3.04825
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.88509
S100A12 S100 calcium binding protein A12 -2.51375
PRUNE2 prune homolog 2 (Drosophila) -2.4275
CHI3L2 chitinase 3-like 2 -2.40585
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.35598
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 -2.28475
ST20-MTHFS ST20-MTHFS readthrough -2.21274
GRN granulin -2.19646
CD3D CD3d molecule, delta (CD3-TCR complex) -2.16114
TAF7 TAF7 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 55kDa -2.13816
IQGAP1 IQ motif containing GTPase activating protein 1 -2.13533
NFE2L2 nuclear factor, erythroid 2-like 2 -2.11029
USP11 ubiquitin specific peptidase 11 -2.10482
ANKRD10 ankyrin repeat domain 10 -2.06893
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.06566
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.05056
DPP8 dipeptidyl-peptidase 8 -2.04379