CRCGN017_MCF10A.TP53.M_24H:C15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description bexarotene 0.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

29 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TCEA2 transcription elongation factor A (SII), 2 5.07477
MAMLD1 mastermind-like domain containing 1 3.59651
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.4033
AGR2 anterior gradient 2 3.33262
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 3.03042
STK10 serine/threonine kinase 10 2.81695
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.78359
TBPL1 TBP-like 1 2.4838
MCUR1 mitochondrial calcium uniporter regulator 1 2.42224
IL1B interleukin 1, beta 2.42101
PRKCH protein kinase C, eta 2.39625
IL2RA interleukin 2 receptor, alpha 2.13103
CHN1 chimerin 1 2.03562
ACAA1 acetyl-CoA acyltransferase 1 2.00935

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -7.01113
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.88998
WASHC4 WASH complex subunit 4 -3.56819
MSN moesin -3.19438
COTL1 coactosin-like F-actin binding protein 1 -3.03036
KRT14 keratin 14, type I -2.909
DSG2 desmoglein 2 -2.64958
CSRP1 cysteine and glycine-rich protein 1 -2.5297
GOLT1B golgi transport 1B -2.45365
SLC25A46 solute carrier family 25, member 46 -2.43374
FOS FBJ murine osteosarcoma viral oncogene homolog -2.33397
PIH1D1 PIH1 domain containing 1 -2.20734
CAB39 calcium binding protein 39 -2.12173
ANKRD10 ankyrin repeat domain 10 -2.03376
EMP3 epithelial membrane protein 3 -2.00874