CRCGN017_MCF10A.TP53.M_24H:C16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrolein 102.99 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

44 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 4.79761
SNAP25 synaptosomal-associated protein, 25kDa 4.57335
BMP4 bone morphogenetic protein 4 2.85322
NSG2 neuronal vesicle trafficking associated 2 2.62651
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.49054
SYT2 synaptotagmin II 2.45552
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.38962
TBPL1 TBP-like 1 2.33664
NPY neuropeptide Y 2.21315
MRPL17 mitochondrial ribosomal protein L17 2.19759
SYT1 synaptotagmin I 2.18806
ATP6V1F ATPase, H+ transporting, lysosomal 14kDa, V1 subunit F 2.17715
CCNE2 cyclin E2 2.15478
SV2B synaptic vesicle glycoprotein 2B 2.11985
DDX39A DEAD (Asp-Glu-Ala-Asp) box polypeptide 39A 2.10003
BCS1L BC1 (ubiquinol-cytochrome c reductase) synthesis-like 2.06665
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) 2.03602
ORC6 origin recognition complex, subunit 6 2.01998
EVL Enah/Vasp-like 2.005

decreased expression

Symbol Name Standardized Value
PUF60 poly-U binding splicing factor 60KDa -7.72824
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -6.7552
SCRIB scribbled planar cell polarity protein -3.93043
GPAA1 glycosylphosphatidylinositol anchor attachment 1 -3.91489
LDHD lactate dehydrogenase D -3.23126
KRT14 keratin 14, type I -3.1662
GSDMD gasdermin D -2.97885
DGAT1 diacylglycerol O-acyltransferase 1 -2.89097
PYCR3 pyrroline-5-carboxylate reductase 3 -2.77784
SLC52A2 solute carrier family 52 (riboflavin transporter), member 2 -2.77213
HSF1 heat shock transcription factor 1 -2.6725
THEM6 thioesterase superfamily member 6 -2.63773
TLK2 tousled-like kinase 2 -2.56218
BOP1 block of proliferation 1 -2.5029
ANKRD10 ankyrin repeat domain 10 -2.47904
HSPA8 heat shock 70kDa protein 8 -2.46793
ZNF7 zinc finger protein 7 -2.43362
CPSF1 cleavage and polyadenylation specific factor 1, 160kDa -2.34346
PRAME preferentially expressed antigen in melanoma -2.18508
GCG glucagon -2.1326
LOC128031832 uncharacterized LOC128031832 -2.08112
HPS4 Hermansky-Pudlak syndrome 4 -2.04479
ZFTRAF1 zinc finger TRAF-type containing 1 -2.0251
ZC3H3 zinc finger CCCH-type containing 3 -2.01814
EHBP1L1 EH domain binding protein 1-like 1 -2.01013