CRCGN017_MCF10A.TP53.M_24H:C17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description acrolein 34.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

28 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:C17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPARG peroxisome proliferator-activated receptor gamma 5.3275
TSEN2 TSEN2 tRNA splicing endonuclease subunit 5.00759
COMP cartilage oligomeric matrix protein 3.29809
ADGRE5 adhesion G protein-coupled receptor E5 3.27774
CNRIP1 cannabinoid receptor interacting protein 1 3.17714
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.7146
IKZF1 IKAROS family zinc finger 1 (Ikaros) 2.62171
TOMM34 translocase of outer mitochondrial membrane 34 2.55526
OLFML2B olfactomedin-like 2B 2.49319
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.42577
CDCA4 cell division cycle associated 4 2.18099
MAP7 microtubule-associated protein 7 2.09323

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -4.79391
ADH5 alcohol dehydrogenase 5 (class III), chi polypeptide -4.50383
KRT14 keratin 14, type I -2.62407
RPLP2 ribosomal protein, large, P2 -2.3611
RBM34 RNA binding motif protein 34 -2.35409
BHMT2 betaine--homocysteine S-methyltransferase 2 -2.32715
ADH7 alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide -2.31376
LRP5 low density lipoprotein receptor-related protein 5 -2.31049
BAX BCL2-associated X protein -2.29862
HEATR1 HEAT repeat containing 1 -2.17749
TOMM20 translocase of outer mitochondrial membrane 20 homolog (yeast) -2.17209
RPL38 ribosomal protein L38 -2.17158
GGPS1 geranylgeranyl diphosphate synthase 1 -2.1268
TKT transketolase -2.09009
ACSM2A acyl-CoA synthetase medium-chain family member 2A -2.0729
WDR26 WD repeat domain 26 -2.04202