CRCGN017_MCF10A.TP53.M_24H:D01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description omeprazole 100.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

199 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:D01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 10.0
SSBP2 single-stranded DNA binding protein 2 5.92905
ZNF586 zinc finger protein 586 5.0894
SNAP25 synaptosomal-associated protein, 25kDa 4.70158
MEF2C myocyte enhancer factor 2C 4.63035
TXNRD1 thioredoxin reductase 1 4.3462
TPD52L2 tumor protein D52-like 2 4.2356
ZNF587 zinc finger protein 587 3.4919
CADM1 cell adhesion molecule 1 3.47762
SHC1 SHC (Src homology 2 domain containing) transforming protein 1 3.43093
HMOX1 heme oxygenase 1 3.3955
RPH3A rabphilin 3A 3.38755
ZNF134 zinc finger protein 134 3.33575
ZNF419 zinc finger protein 419 3.31245
ZNF304 zinc finger protein 304 3.2928
KDM5D lysine (K)-specific demethylase 5D 3.1385
ACAA1 acetyl-CoA acyltransferase 1 3.0831
BACE2 beta-site APP-cleaving enzyme 2 3.04125
TSKU tsukushi, small leucine rich proteoglycan 2.9962
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.931
PPIB peptidylprolyl isomerase B (cyclophilin B) 2.92708
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.92565
CCNL2 cyclin L2 2.907
MYOC myocilin, trabecular meshwork inducible glucocorticoid response 2.8774
GABRA1 gamma-aminobutyric acid (GABA) A receptor, alpha 1 2.8738
CNRIP1 cannabinoid receptor interacting protein 1 2.8497
ZNF587B zinc finger protein 587B 2.82385
POLD4 polymerase (DNA-directed), delta 4, accessory subunit 2.82245
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.7678
NME3 NME/NM23 nucleoside diphosphate kinase 3 2.75085
ZNF432 zinc finger protein 432 2.7258
NEFL neurofilament, light polypeptide 2.69737
STMN2 stathmin 2 2.69243
TAC1 tachykinin, precursor 1 2.67215
IFI6 interferon, alpha-inducible protein 6 2.65015
NQO1 NAD(P)H dehydrogenase, quinone 1 2.64345
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.6392
NFS1 NFS1 cysteine desulfurase 2.62865
SPANXA1 sperm protein associated with the nucleus, X-linked, family member A1 2.62578
DUSP5 dual specificity phosphatase 5 2.60635
GLRX glutaredoxin (thioltransferase) 2.60165
CALCOCO1 calcium binding and coiled-coil domain 1 2.59875
GALE UDP-galactose-4-epimerase 2.59565
H2BC12 H2B clustered histone 12 2.58007
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) 2.5693
HOOK2 hook microtubule-tethering protein 2 2.56415
USP9Y ubiquitin specific peptidase 9, Y-linked 2.51353
CDK5 cyclin-dependent kinase 5 2.50885
FBXW7 F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase 2.50885
ZNF124 zinc finger protein 124 2.504
HBA1 hemoglobin, alpha 1 2.49957
GPATCH2 G patch domain containing 2 2.49585
PSENEN presenilin enhancer gamma secretase subunit 2.47395
NEFM neurofilament, medium polypeptide 2.4509
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.4423
NPTX1 neuronal pentraxin I 2.43475
DEPTOR DEP domain containing MTOR-interacting protein 2.3873
UGDH UDP-glucose 6-dehydrogenase 2.37565
AARS1 alanyl-tRNA synthetase 1 2.3754
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.375
NUP133 nucleoporin 133kDa 2.36945
EID1 EP300 interacting inhibitor of differentiation 1 2.36178
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.3566
DNAJC17 DnaJ (Hsp40) homolog, subfamily C, member 17 2.337
TDO2 tryptophan 2,3-dioxygenase 2.3245
AK5 adenylate kinase 5 2.3238
SYT1 synaptotagmin I 2.31877
PLSCR1 phospholipid scramblase 1 2.31242
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.3092
NECTIN4 nectin cell adhesion molecule 4 2.2919
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.2904
RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2 2.2786
NRIP3 nuclear receptor interacting protein 3 2.27
FKBP11 FK506 binding protein 11, 19 kDa 2.26828
PRKCD protein kinase C, delta 2.26715
CHKA choline kinase alpha 2.2441
SNRNP70 small nuclear ribonucleoprotein 70kDa (U1) 2.24097
TBC1D12 TBC1 domain family, member 12 2.2398
PRH1 proline-rich protein HaeIII subfamily 1 2.2397
AKR1C3 aldo-keto reductase family 1, member C3 2.2257
SKIC2 SKI2 subunit of superkiller complex 2.2184
SLC17A7 solute carrier family 17 (vesicular glutamate transporter), member 7 2.2184
RUNDC3B RUN domain containing 3B 2.20495
GNG7 guanine nucleotide binding protein (G protein), gamma 7 2.2001
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.1988
SLC12A8 solute carrier family 12, member 8 2.18695
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.18575
ACIN1 apoptotic chromatin condensation inducer 1 2.18045
POU2AF1 POU class 2 associating factor 1 2.17865
BTBD2 BTB (POZ) domain containing 2 2.17605
ACADVL acyl-CoA dehydrogenase, very long chain 2.17425
ROGDI rogdi homolog (Drosophila) 2.1653
NIT1 nitrilase 1 2.1548
NRGN neurogranin (protein kinase C substrate, RC3) 2.15075
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 2.15065
ZNF148 zinc finger protein 148 2.14468
ASNS asparagine synthetase (glutamine-hydrolyzing) 2.1366
UROS uroporphyrinogen III synthase 2.13285
TF transferrin 2.11999
RNPEP arginyl aminopeptidase (aminopeptidase B) 2.11573
RNF146 ring finger protein 146 2.11485
PNKP polynucleotide kinase 3'-phosphatase 2.09115
DYNC1LI2 dynein, cytoplasmic 1, light intermediate chain 2 2.09095
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 2.0783
GCLM glutamate-cysteine ligase, modifier subunit 2.0746
ASPHD1 aspartate beta-hydroxylase domain containing 1 2.0552
U2AF2 U2 small nuclear RNA auxiliary factor 2 2.04425
TMEM183A transmembrane protein 183A 2.04308
ZNF451 zinc finger protein 451 2.04093
ZNF665 zinc finger protein 665 2.02015
ATP2B1 ATPase, Ca++ transporting, plasma membrane 1 2.01037
H2BC21 H2B clustered histone 21 2.00985
ZNF350 zinc finger protein 350 2.00735
TNNT1 troponin T type 1 (skeletal, slow) 2.0029

decreased expression

Symbol Name Standardized Value
TNIP1 TNFAIP3 interacting protein 1 -5.2205
RPIA ribose 5-phosphate isomerase A -5.2122
YME1L1 YME1-like 1 ATPase -4.81112
SMC1A structural maintenance of chromosomes 1A -4.0883
IGFBP7 insulin-like growth factor binding protein 7 -3.66603
CD81 CD81 molecule -3.6301
WASHC4 WASH complex subunit 4 -3.61995
DCK deoxycytidine kinase -3.57605
CD320 CD320 molecule -3.4684
UBA1 ubiquitin-like modifier activating enzyme 1 -3.24155
JAK1 Janus kinase 1 -3.06185
ANXA3 annexin A3 -3.0537
ADRB2 adrenoceptor beta 2, surface -3.0461
ABI1 abl-interactor 1 -2.94357
FXYD6-FXYD2 FXYD6-FXYD2 readthrough -2.8819
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 -2.80885
MSN moesin -2.7745
CDK4 cyclin-dependent kinase 4 -2.7335
ANXA6 annexin A6 -2.70475
CDC23 cell division cycle 23 -2.6863
PDZD8 PDZ domain containing 8 -2.6759
LAS1L LAS1-like (S. cerevisiae) -2.65035
MMP10 matrix metallopeptidase 10 -2.6256
DYRK4 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 4 -2.6104
TSPAN8 tetraspanin 8 -2.60855
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 -2.5938
TCEAL4 transcription elongation factor A (SII)-like 4 -2.58945
OTUB2 OTU deubiquitinase, ubiquitin aldehyde binding 2 -2.5624
LMO7 LIM domain 7 -2.5607
CANT1 calcium activated nucleotidase 1 -2.54685
CAVIN2 caveolae associated protein 2 -2.51465
BNIP3L BCL2/adenovirus E1B 19kDa interacting protein 3-like -2.5045
USP9X ubiquitin specific peptidase 9, X-linked -2.50178
POF1B premature ovarian failure, 1B -2.48995
SEPSECS Sep (O-phosphoserine) tRNA:Sec (selenocysteine) tRNA synthase -2.48607
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.45085
PDSS1 prenyl (decaprenyl) diphosphate synthase, subunit 1 -2.43375
MATN2 matrilin 2 -2.43225
DAAM1 dishevelled associated activator of morphogenesis 1 -2.4213
PVR poliovirus receptor -2.40477
MTPAP mitochondrial poly(A) polymerase -2.3923
WAC WW domain containing adaptor with coiled-coil -2.38993
RANBP10 RAN binding protein 10 -2.37038
MAT2B methionine adenosyltransferase II, beta -2.3653
ILK integrin-linked kinase -2.34665
HSPA1A heat shock 70kDa protein 1A -2.33205
ATP5F1C ATP synthase F1 subunit gamma -2.33082
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.28975
ADPRM ADP-ribose/CDP-alcohol diphosphatase, manganese-dependent -2.2664
HOXA5 homeobox A5 -2.24875
UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 -2.2454
CEACAM5 carcinoembryonic antigen-related cell adhesion molecule 5 -2.2403
FERMT1 fermitin family member 1 -2.20543
KDM6A lysine (K)-specific demethylase 6A -2.19777
IL36G interleukin 36, gamma -2.18695
PUDP pseudouridine 5'-phosphatase -2.18365
OPTN optineurin -2.18097
NR1I2 nuclear receptor subfamily 1, group I, member 2 -2.17185
CEACAM6 carcinoembryonic antigen-related cell adhesion molecule 6 (non-specific cross reacting antigen) -2.17002
PTTG1IP pituitary tumor-transforming 1 interacting protein -2.16975
ZNF185 zinc finger protein 185 (LIM domain) -2.15745
SPARCL1 SPARC-like 1 (hevin) -2.1538
MAFB v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog B -2.12515
DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 -2.11815
EXT2 exostosin glycosyltransferase 2 -2.11565
TCF21 transcription factor 21 -2.1123
PLK1 polo-like kinase 1 -2.0855
ARHGDIB Rho GDP dissociation inhibitor (GDI) beta -2.08065
NANOS2 nanos homolog 2 (Drosophila) -2.0798
XYLT2 xylosyltransferase II -2.062
MCM10 minichromosome maintenance complex component 10 -2.05845
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.05835
RBBP8 retinoblastoma binding protein 8 -2.05805
SERPINB1 serpin peptidase inhibitor, clade B (ovalbumin), member 1 -2.05725
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B -2.05455
CYP7A1 cytochrome P450, family 7, subfamily A, polypeptide 1 -2.05445
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A -2.0487
SLC7A6 solute carrier family 7 (amino acid transporter light chain, y+L system), member 6 -2.04833
IFI27 interferon, alpha-inducible protein 27 -2.0421
POGLUT1 protein O-glucosyltransferase 1 -2.0355
DYSF dysferlin -2.02515
PHB2 prohibitin 2 -2.02285
MAGEL2 melanoma antigen family L2 -2.022
HOXA4 homeobox A4 -2.01095
TRAF1 TNF receptor-associated factor 1 -2.0086