CRCGN017_MCF10A.TP53.M_24H:D08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 3.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

48 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:D08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TCEA2 transcription elongation factor A (SII), 2 4.81004
ADAM10 ADAM metallopeptidase domain 10 4.6847
MAMLD1 mastermind-like domain containing 1 4.6001
NOTCH1 notch 1 4.59415
IL1B interleukin 1, beta 3.44647
HOXA5 homeobox A5 3.36789
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.25343
DHRS2 dehydrogenase/reductase (SDR family) member 2 3.14364
COMP cartilage oligomeric matrix protein 3.11822
CDC45 cell division cycle 45 3.08488
EVL Enah/Vasp-like 2.63131
TOMM34 translocase of outer mitochondrial membrane 34 2.4525
H2BC21 H2B clustered histone 21 2.31696
RALY RALY heterogeneous nuclear ribonucleoprotein 2.2862
PRKCH protein kinase C, eta 2.14994
MAPK1 mitogen-activated protein kinase 1 2.14988
SLC75A1 solute carrier family 75 member 1 2.10377
TSPAN13 tetraspanin 13 2.09112
CRELD2 cysteine-rich with EGF-like domains 2 2.05153
RPL39L ribosomal protein L39-like 2.04404
TERT telomerase reverse transcriptase 2.04302
BZW2 basic leucine zipper and W2 domains 2 2.01897
SQOR sulfide quinone oxidoreductase 2.00531

decreased expression

Symbol Name Standardized Value
GTPBP8 GTP-binding protein 8 (putative) -4.92886
NPDC1 neural proliferation, differentiation and control, 1 -4.44141
MSMO1 methylsterol monooxygenase 1 -3.63112
PCCB propionyl CoA carboxylase, beta polypeptide -3.36305
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.15752
S100A4 S100 calcium binding protein A4 -2.967
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.6491
BASP1 brain abundant, membrane attached signal protein 1 -2.60327
SLC35A5 solute carrier family 35, member A5 -2.44496
KRT14 keratin 14, type I -2.40959
CCNT1 cyclin T1 -2.32912
ANKRD10 ankyrin repeat domain 10 -2.30809
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.29478
RGS2 regulator of G-protein signaling 2 -2.28998
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.24446
RABL3 RAB, member of RAS oncogene family-like 3 -2.2258
SLC25A36 solute carrier family 25 (pyrimidine nucleotide carrier), member 36 -2.16819
DNAJB14 DnaJ (Hsp40) homolog, subfamily B, member 14 -2.11681
SQLE squalene epoxidase -2.06682
PPIG peptidylprolyl isomerase G (cyclophilin G) -2.04547
CHGB chromogranin B -2.04124
RGS5 regulator of G-protein signaling 5 -2.03554
ABCB7 ATP-binding cassette, sub-family B (MDR/TAP), member 7 -2.02381
TCTN1 tectonic family member 1 -2.02181
ZNF148 zinc finger protein 148 -2.00669