CRCGN017_MCF10A.TP53.M_24H:D09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tretinoin 1.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

45 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:D09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
TCEA2 transcription elongation factor A (SII), 2 6.24605
HOXA5 homeobox A5 5.76835
EPHB2 EPH receptor B2 3.4402
MAMLD1 mastermind-like domain containing 1 3.21122
LGMN legumain 3.07996
IL1B interleukin 1, beta 2.9479
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 2.83254
NRIP1 nuclear receptor interacting protein 1 2.79066
FHL2 four and a half LIM domains 2 2.4606
CCL2 chemokine (C-C motif) ligand 2 2.45535
PDLIM1 PDZ and LIM domain 1 2.43234
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.4045
PLSCR1 phospholipid scramblase 1 2.38634
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 2.3431
PLAT plasminogen activator, tissue 2.33839
RBP4 retinol binding protein 4, plasma 2.31972
HOXA4 homeobox A4 2.28647
LHX6 LIM homeobox 6 2.23993
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough 2.21701
AGR2 anterior gradient 2 2.20073
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.14052
TSPAN6 tetraspanin 6 2.11089
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.06597
GTPBP8 GTP-binding protein 8 (putative) 2.04386
PRPF18 pre-mRNA processing factor 18 2.02612
ELOVL6 ELOVL fatty acid elongase 6 2.02513

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -8.27785
RGS2 regulator of G-protein signaling 2 -4.18808
CHMP4B charged multivesicular body protein 4B -4.09416
NUP85 nucleoporin 85kDa -3.11983
S100A4 S100 calcium binding protein A4 -3.03776
CCNB2 cyclin B2 -2.84011
NT5DC2 5'-nucleotidase domain containing 2 -2.6373
PIH1D1 PIH1 domain containing 1 -2.57155
MRPS7 mitochondrial ribosomal protein S7 -2.31874
TAC4 tachykinin 4 (hemokinin) -2.28332
NRDC nardilysin convertase -2.23415
NT5C 5', 3'-nucleotidase, cytosolic -2.17022
KCTD2 potassium channel tetramerization domain containing 2 -2.1077
SPAG7 sperm associated antigen 7 -2.06999
BCL2L2 BCL2-like 2 -2.05768
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.05445
XRCC1 X-ray repair complementing defective repair in Chinese hamster cells 1 -2.04866
RAB5B RAB5B, member RAS oncogene family -2.04663
FXR2 fragile X mental retardation, autosomal homolog 2 -2.04454