CRCGN017_MCF10A.TP53.M_24H:D10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description lg100754 1.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

46 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:D10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CLNS1A chloride channel, nucleotide-sensitive, 1A 4.91003
CCL2 chemokine (C-C motif) ligand 2 4.23435
AAMDC adipogenesis associated, Mth938 domain containing 4.18034
KIF5C kinesin family member 5C 3.9082
ALG8 ALG8, alpha-1,3-glucosyltransferase 3.80706
RSF1 remodeling and spacing factor 1 3.79319
PKN1 protein kinase N1 3.67691
SNX11 sorting nexin 11 3.4573
HOXA5 homeobox A5 3.44177
NARS2 asparaginyl-tRNA synthetase 2, mitochondrial (putative) 3.19602
EMSY EMSY transcriptional repressor, BRCA2 interacting 3.18791
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 3.18534
THAP12 THAP domain containing 12 3.01347
CGRRF1 cell growth regulator with ring finger domain 1 2.61828
TRAK2 trafficking protein, kinesin binding 2 2.56402
COA4 cytochrome c oxidase assembly factor 4 homolog (S. cerevisiae) 2.40253
GPER1 G protein-coupled estrogen receptor 1 2.39214
HBA1 hemoglobin, alpha 1 2.31327
HMOX1 heme oxygenase 1 2.29578
RAB21 RAB21, member RAS oncogene family 2.25018
CCNA1 cyclin A1 2.21249
KCTD14 potassium channel tetramerization domain containing 14 2.19789
CNPY3 canopy FGF signaling regulator 3 2.15837
OLFML2B olfactomedin-like 2B 2.1428
WDR6 WD repeat domain 6 2.1262
BLMH bleomycin hydrolase 2.10797
GAB2 GRB2-associated binding protein 2 2.06847
CACNA2D3 calcium channel, voltage-dependent, alpha 2/delta subunit 3 2.06776
UVRAG UV radiation resistance associated 2.02525
HBB hemoglobin, beta 2.0148

decreased expression

Symbol Name Standardized Value
SNCA synuclein, alpha (non A4 component of amyloid precursor) -3.894
GDF15 growth differentiation factor 15 -3.88077
CHIC2 cysteine-rich hydrophobic domain 2 -3.31156
TRIB3 tribbles pseudokinase 3 -2.92395
KIF14 kinesin family member 14 -2.69002
BASP1 brain abundant, membrane attached signal protein 1 -2.66078
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.52531
C2CD5 C2 calcium-dependent domain containing 5 -2.41872
SAA4 serum amyloid A4, constitutive -2.38832
SAA2 serum amyloid A2 -2.31604
LBP lipopolysaccharide binding protein -2.31479
RPL18A ribosomal protein L18a -2.25954
MTERF3 mitochondrial transcription termination factor 3 -2.1577
CASZ1 castor zinc finger 1 -2.06888
IGFBP1 insulin-like growth factor binding protein 1 -2.05713
PPP1R15A protein phosphatase 1, regulatory subunit 15A -2.04483