CRCGN017_MCF10A.TP53.M_24H:D13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description galangin with tcdd perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

60 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:D13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SNAP25 synaptosomal-associated protein, 25kDa 5.38785
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 5.22872
GRB10 growth factor receptor-bound protein 10 3.69395
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.65831
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.58431
PDLIM1 PDZ and LIM domain 1 3.3396
KDM5D lysine (K)-specific demethylase 5D 3.12704
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 2.78682
TRAPPC4 trafficking protein particle complex 4 2.68055
NSG2 neuronal vesicle trafficking associated 2 2.65599
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 2.63084
SCG3 secretogranin III 2.60878
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.52742
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase 2.47653
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.45566
SYN1 synapsin I 2.45305
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.41745
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide 2.39197
FBXO11 F-box protein 11 2.32164
USP9Y ubiquitin specific peptidase 9, Y-linked 2.31029
EVL Enah/Vasp-like 2.23803
PGAP4 post-GPI attachment to proteins GalNAc transferase 4 2.20958
MYT1L myelin transcription factor 1-like 2.19646
GALNT14 polypeptide N-acetylgalactosaminyltransferase 14 2.17336
RPH3A rabphilin 3A 2.16784
RUNDC3B RUN domain containing 3B 2.15741
LGR4 leucine-rich repeat containing G protein-coupled receptor 4 2.1208
SYT1 synaptotagmin I 2.11589
AHR aryl hydrocarbon receptor 2.09483
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.09288
DZIP1 DAZ interacting zinc finger protein 1 2.07356
LGI1 leucine-rich, glioma inactivated 1 2.06245
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 2.0388
GABRG2 gamma-aminobutyric acid (GABA) A receptor, gamma 2 2.02599
ATP7B ATPase, Cu++ transporting, beta polypeptide 2.01607
CETN3 centrin, EF-hand protein, 3 2.00784
STMN2 stathmin 2 2.00534
SLC12A5 solute carrier family 12 (potassium/chloride transporter), member 5 2.00492

decreased expression

Symbol Name Standardized Value
HMG20B high mobility group 20B -5.02394
KRT14 keratin 14, type I -4.32078
CD44 CD44 molecule (Indian blood group) -4.03095
PTK2 protein tyrosine kinase 2 -3.51883
FPGS folylpolyglutamate synthase -3.40523
GDF15 growth differentiation factor 15 -3.00349
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.93991
MSN moesin -2.82607
TUBA4A tubulin, alpha 4a -2.76335
ANXA2 annexin A2 -2.7571
TKT transketolase -2.42736
UBA1 ubiquitin-like modifier activating enzyme 1 -2.40277
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.37148
KDM3A lysine (K)-specific demethylase 3A -2.35371
S100A7 S100 calcium binding protein A7 -2.33903
CDKN1C cyclin-dependent kinase inhibitor 1C (p57, Kip2) -2.28403
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.15004
ARFIP2 ADP-ribosylation factor interacting protein 2 -2.06493
CLIC3 chloride intracellular channel 3 -2.06155
EEIG1 estrogen-induced osteoclastogenesis regulator 1 -2.05789
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa -2.05764
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.01324