CRCGN017_MCF10A.TP53.M_24H:D18 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description chlorpropamide 11.16 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:D18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
UBQLN2 ubiquilin 2 3.67087
MAMLD1 mastermind-like domain containing 1 3.516
APBB2 amyloid beta (A4) precursor protein-binding, family B, member 2 3.4187
LOC122526780 uncharacterized LOC122526780 2.82468
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.50682
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.45747
ACAA1 acetyl-CoA acyltransferase 1 2.43588
CCP110 centriolar coiled coil protein 110kDa 2.41431
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.05944
IQGAP2 IQ motif containing GTPase activating protein 2 2.00587

decreased expression

Symbol Name Standardized Value
TXNDC9 thioredoxin domain containing 9 -5.71067
MRPS2 mitochondrial ribosomal protein S2 -4.37151
PAEP progestagen-associated endometrial protein -3.76157
CTNND1 catenin (cadherin-associated protein), delta 1 -3.46463
KRT14 keratin 14, type I -3.0165
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.87614
ANKRD10 ankyrin repeat domain 10 -2.36022
LMAN2L lectin, mannose-binding 2-like -2.34988
UBAC1 UBA domain containing 1 -2.34748
HMG20B high mobility group 20B -2.30136
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.25289
UNC50 unc-50 homolog (C. elegans) -2.24296
PLEKHF2 pleckstrin homology domain containing, family F (with FYVE domain) member 2 -2.14128
FBXO7 F-box protein 7 -2.09613
SOWAHC sosondowah ankyrin repeat domain family member C -2.0724
OBP2B odorant binding protein 2B -2.04249
TMEM131 transmembrane protein 131 -2.0077