CRCGN017_MCF10A.TP53.M_24H:D19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 2-aminofluorene 99.15 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

55 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:D19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PNKP polynucleotide kinase 3'-phosphatase 4.67564
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.66374
SPAG4 sperm associated antigen 4 4.36563
E2F2 E2F transcription factor 2 4.10382
ARID5B AT rich interactive domain 5B (MRF1-like) 3.89777
ZNF586 zinc finger protein 586 3.05334
USP6NL USP6 N-terminal like 3.05095
KDM5A lysine (K)-specific demethylase 5A 2.68414
ALDOC aldolase C, fructose-bisphosphate 2.58629
INPP1 inositol polyphosphate-1-phosphatase 2.51792
FDFT1 farnesyl-diphosphate farnesyltransferase 1 2.41311
ANO1 anoctamin 1, calcium activated chloride channel 2.39098
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 2.38041
PRRX2 paired related homeobox 2 2.36615
PORCN porcupine homolog (Drosophila) 2.30501
EGR1 early growth response 1 2.25459
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.20514
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.20144
HCFC2 host cell factor C2 2.19966
CCT6A chaperonin containing TCP1, subunit 6A (zeta 1) 2.19005
HABP4 hyaluronan binding protein 4 2.15282
PPARG peroxisome proliferator-activated receptor gamma 2.14784
VEGFC vascular endothelial growth factor C 2.14305
SKIC2 SKI2 subunit of superkiller complex 2.12193
NLRP1 NLR family, pyrin domain containing 1 2.1013
RBM6 RNA binding motif protein 6 2.09872
IL1B interleukin 1, beta 2.05644
ZNF451 zinc finger protein 451 2.04037
CRLF1 cytokine receptor-like factor 1 2.03473
CDC25B cell division cycle 25B 2.03019
TIPARP TCDD-inducible poly(ADP-ribose) polymerase 2.01238
HSD17B1 hydroxysteroid (17-beta) dehydrogenase 1 2.00824

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -4.484
TSPAN4 tetraspanin 4 -4.25526
TXNDC9 thioredoxin domain containing 9 -4.05887
TUBB6 tubulin, beta 6 class V -4.0328
BAG3 BCL2-associated athanogene 3 -3.96008
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -3.16889
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -3.15402
EIF5 eukaryotic translation initiation factor 5 -2.8012
ADRB2 adrenoceptor beta 2, surface -2.78528
PCCB propionyl CoA carboxylase, beta polypeptide -2.55582
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -2.52375
C2CD5 C2 calcium-dependent domain containing 5 -2.37846
ANKRD10 ankyrin repeat domain 10 -2.3664
CCDC47 coiled-coil domain containing 47 -2.30193
ATP11B ATPase, class VI, type 11B -2.29161
BASP1 brain abundant, membrane attached signal protein 1 -2.22525
PCNT pericentrin -2.21704
RAD51C RAD51 paralog C -2.20623
MLH1 mutL homolog 1 -2.20018
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.11138
ZIC1 Zic family member 1 -2.08222
PRR15L proline rich 15-like -2.06058
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.00834