CRCGN017_MCF10A.TP53.M_24H:D22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3,3'-dimethoxybenzidine.2hcl 96.28 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

246 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:D22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 6.9348
ADO 2-aminoethanethiol (cysteamine) dioxygenase 6.12607
WFS1 Wolfram syndrome 1 (wolframin) 5.51675
LGMN legumain 5.0401
SPAG4 sperm associated antigen 4 4.82095
C2CD2 C2 calcium-dependent domain containing 2 4.66365
PPOX protoporphyrinogen oxidase 4.64395
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 4.07303
ALDOC aldolase C, fructose-bisphosphate 3.698
ADAM10 ADAM metallopeptidase domain 10 3.31715
STXBP1 syntaxin binding protein 1 3.2545
ALDH3B1 aldehyde dehydrogenase 3 family, member B1 3.14475
ZBED5 zinc finger, BED-type containing 5 3.1376
INSIG1 insulin induced gene 1 3.04993
MAN2B2 mannosidase, alpha, class 2B, member 2 3.01075
TSPAN8 tetraspanin 8 2.9327
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 2.9229
CNIH3 cornichon family AMPA receptor auxiliary protein 3 2.9127
CARS2 cysteinyl-tRNA synthetase 2, mitochondrial (putative) 2.86555
NARS1 asparaginyl-tRNA synthetase 1 2.82085
PDGFA platelet-derived growth factor alpha polypeptide 2.7874
BIRC7 baculoviral IAP repeat containing 7 2.76415
NBPF3 neuroblastoma breakpoint family, member 3 2.7128
PRAF2 PRA1 domain family, member 2 2.7108
NUCB2 nucleobindin 2 2.6759
ATP5IF1 ATP synthase inhibitory factor subunit 1 2.6496
VAT1 vesicle amine transport 1 2.6292
GPER1 G protein-coupled estrogen receptor 1 2.62652
S100A4 S100 calcium binding protein A4 2.6125
SLC26A2 solute carrier family 26 (anion exchanger), member 2 2.5731
APPL2 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 2 2.5592
NDUFB1 NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 1, 7kDa 2.55705
PCDHGA5 protocadherin gamma subfamily A, 5 2.5567
LAMA2 laminin, alpha 2 2.52728
NRDC nardilysin convertase 2.52655
PRX periaxin 2.51475
MYL5 myosin, light chain 5, regulatory 2.5042
MOAP1 modulator of apoptosis 1 2.47265
RAB3A RAB3A, member RAS oncogene family 2.4414
SPATA2L spermatogenesis associated 2-like 2.43755
LRRC37A3 leucine rich repeat containing 37, member A3 2.4295
ANKRD27 ankyrin repeat domain 27 (VPS9 domain) 2.42035
FZD7 frizzled class receptor 7 2.41348
MOXD1 monooxygenase, DBH-like 1 2.39505
TXNRD1 thioredoxin reductase 1 2.38965
TRIM36 tripartite motif containing 36 2.3866
CPZ carboxypeptidase Z 2.36125
OCEL1 occludin/ELL domain containing 1 2.35305
CHL1 cell adhesion molecule L1-like 2.3511
CEMIP2 cell migration inducing hyaluronidase 2 2.347
ZNF451 zinc finger protein 451 2.33512
CDC16 cell division cycle 16 2.32023
DNAH9 dynein, axonemal, heavy chain 9 2.31935
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.31585
TMEM80 transmembrane protein 80 2.31023
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.30155
MAP2K5 mitogen-activated protein kinase kinase 5 2.28888
B3GAT3 beta-1,3-glucuronyltransferase 3 2.2885
CALU calumenin 2.28235
PCCA propionyl CoA carboxylase, alpha polypeptide 2.2692
SYNRG synergin, gamma 2.26813
MAP1LC3C microtubule-associated protein 1 light chain 3 gamma 2.26665
OSBPL9 oxysterol binding protein-like 9 2.2604
PCYOX1L prenylcysteine oxidase 1 like 2.2454
PPM1H protein phosphatase, Mg2+/Mn2+ dependent, 1H 2.2414
LIG4 ligase IV, DNA, ATP-dependent 2.2413
TMEM231 transmembrane protein 231 2.2411
QSOX1 quiescin Q6 sulfhydryl oxidase 1 2.2316
GLRX glutaredoxin (thioltransferase) 2.22902
TMC5 transmembrane channel-like 5 2.22185
TUBG2 tubulin, gamma 2 2.22145
GOLGA3 golgin A3 2.2187
KCTD7 potassium channel tetramerization domain containing 7 2.21065
TMEM255A transmembrane protein 255A 2.20205
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 2.1995
TUG1 taurine up-regulated 1 (non-protein coding) 2.19842
P4HA2 prolyl 4-hydroxylase, alpha polypeptide II 2.1938
JMJD1C jumonji domain containing 1C 2.1919
CD46 CD46 molecule, complement regulatory protein 2.1832
NRBF2 nuclear receptor binding factor 2 2.1727
LAGE3 L antigen family, member 3 2.17135
S100A3 S100 calcium binding protein A3 2.16935
SCCPDH saccharopine dehydrogenase (putative) 2.15178
CES1 carboxylesterase 1 2.1363
ACSBG1 acyl-CoA synthetase bubblegum family member 1 2.1361
NEK9 NIMA-related kinase 9 2.13032
SMAD2 SMAD family member 2 2.12907
PLA2G15 phospholipase A2, group XV 2.12575
MLPH melanophilin 2.1248
ASAP1 ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 2.12015
GAA glucosidase, alpha; acid 2.119
ST6GALNAC4 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4 2.1185
IL20RA interleukin 20 receptor, alpha 2.118
CDH22 cadherin 22, type 2 2.1067
SLC50A1 solute carrier family 50 (sugar efflux transporter), member 1 2.10515
SLC18A2 solute carrier family 18 (vesicular monoamine transporter), member 2 2.09015
GSAP gamma-secretase activating protein 2.08857
PSEN2 presenilin 2 2.0873
DMAC2L distal membrane arm assembly component 2 like 2.08558
CCDC6 coiled-coil domain containing 6 2.07625
MOSPD1 motile sperm domain containing 1 2.076
TMEM187 transmembrane protein 187 2.0655
CDPF1 cysteine-rich, DPF motif domain containing 1 2.06245
GNA12 guanine nucleotide binding protein (G protein) alpha 12 2.0589
SEC31A SEC31 homolog A (S. cerevisiae) 2.05743
AAMDC adipogenesis associated, Mth938 domain containing 2.05693
FOXJ1 forkhead box J1 2.0496
ARF4 ADP-ribosylation factor 4 2.04733
IRGQ immunity-related GTPase family, Q 2.04628
ADAM28 ADAM metallopeptidase domain 28 2.04533
OR10H1 olfactory receptor, family 10, subfamily H, member 1 2.04045
PGC progastricsin (pepsinogen C) 2.0395
CZIB CXXC motif containing zinc binding protein 2.039
GNPAT glyceronephosphate O-acyltransferase 2.03755
GARRE1 granule associated Rac and RHOG effector 1 2.03315
CGB8 chorionic gonadotropin, beta polypeptide 8 2.01925
MFSD6 major facilitator superfamily domain containing 6 2.00505
PDIA2 protein disulfide isomerase family A, member 2 2.0017
SYNE3 spectrin repeat containing, nuclear envelope family member 3 2.00115

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -8.45505
HMG20B high mobility group 20B -5.46217
PGAM4 phosphoglycerate mutase family member 4 -5.24435
LAP3 leucine aminopeptidase 3 -5.1706
TLK2 tousled-like kinase 2 -4.9328
ARPP19 cAMP-regulated phosphoprotein, 19kDa -4.33593
ADRB2 adrenoceptor beta 2, surface -4.0371
SLC25A28 solute carrier family 25 (mitochondrial iron transporter), member 28 -3.2977
TACO1 translational activator of mitochondrially encoded cytochrome c oxidase I -3.20425
KIF11 kinesin family member 11 -3.18935
KCNK5 potassium channel, two pore domain subfamily K, member 5 -2.9831
IGSF3 immunoglobulin superfamily, member 3 -2.98305
IFIT3 interferon-induced protein with tetratricopeptide repeats 3 -2.94665
CXCL9 chemokine (C-X-C motif) ligand 9 -2.92425
TNFRSF4 tumor necrosis factor receptor superfamily, member 4 -2.89225
PLP2 proteolipid protein 2 (colonic epithelium-enriched) -2.8377
BRD7 bromodomain containing 7 -2.827
S100A1 S100 calcium binding protein A1 -2.8193
IFIT5 interferon-induced protein with tetratricopeptide repeats 5 -2.7983
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit -2.78933
ADRM1 adhesion regulating molecule 1 -2.78075
ADAMTS3 ADAM metallopeptidase with thrombospondin type 1 motif, 3 -2.7358
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 -2.68805
OAS2 2'-5'-oligoadenylate synthetase 2, 69/71kDa -2.66265
FOXE1 forkhead box E1 -2.6384
MAP3K14 mitogen-activated protein kinase kinase kinase 14 -2.6264
CRYBG1 crystallin beta-gamma domain containing 1 -2.60985
TK1 thymidine kinase 1, soluble -2.5868
OASL 2'-5'-oligoadenylate synthetase-like -2.56603
CXCL11 chemokine (C-X-C motif) ligand 11 -2.56445
ZGPAT zinc finger, CCCH-type with G patch domain -2.5407
IFIT2 interferon-induced protein with tetratricopeptide repeats 2 -2.5345
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.4989
MMP9 matrix metallopeptidase 9 -2.4917
ANO3 anoctamin 3 -2.4825
CEP55 centrosomal protein 55kDa -2.4795
GINS3 GINS complex subunit 3 (Psf3 homolog) -2.46812
AFM afamin -2.4669
GPR87 G protein-coupled receptor 87 -2.4513
LAG3 lymphocyte-activation gene 3 -2.4479
SLC17A1 solute carrier family 17 (organic anion transporter), member 1 -2.4089
RPA3 replication protein A3, 14kDa -2.38305
MCTP2 multiple C2 domains, transmembrane 2 -2.3825
KIF20A kinesin family member 20A -2.3724
RYR1 ryanodine receptor 1 (skeletal) -2.35355
HPD 4-hydroxyphenylpyruvate dioxygenase -2.34375
NAGPA N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase -2.3433
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.34065
SLC17A3 solute carrier family 17 (organic anion transporter), member 3 -2.3378
RNF128 ring finger protein 128, E3 ubiquitin protein ligase -2.3349
HSPA1A heat shock 70kDa protein 1A -2.33395
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.33047
LMNB1 lamin B1 -2.3295
SASH1 SAM and SH3 domain containing 1 -2.32647
NINJ1 ninjurin 1 -2.3064
PLEKHA1 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1 -2.3009
KCNJ15 potassium channel, inwardly rectifying subfamily J, member 15 -2.3003
IDO1 indoleamine 2,3-dioxygenase 1 -2.28765
PYDC1 PYD (pyrin domain) containing 1 -2.2838
MMP13 matrix metallopeptidase 13 -2.27955
BSPRY B-box and SPRY domain containing -2.27685
SARS2 seryl-tRNA synthetase 2, mitochondrial -2.27455
CHAD chondroadherin -2.27245
PSMC5 proteasome (prosome, macropain) 26S subunit, ATPase, 5 -2.26565
DSG3 desmoglein 3 -2.26515
EHHADH enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase -2.25735
RAP2C RAP2C, member of RAS oncogene family -2.25428
MT1G metallothionein 1G -2.25395
NRGN neurogranin (protein kinase C substrate, RC3) -2.24805
SECTM1 secreted and transmembrane 1 -2.2434
RNF19B ring finger protein 19B -2.23145
IL12RB2 interleukin 12 receptor, beta 2 -2.23045
FGFBP1 fibroblast growth factor binding protein 1 -2.22155
LY6E lymphocyte antigen 6 complex, locus E -2.2213
FAM50B family with sequence similarity 50, member B -2.2177
HERC5 HECT and RLD domain containing E3 ubiquitin protein ligase 5 -2.2115
SLC12A1 solute carrier family 12 (sodium/potassium/chloride transporter), member 1 -2.205
SLC6A12 solute carrier family 6 (neurotransmitter transporter), member 12 -2.17635
TLE5 TLE family member 5, transcriptional modulator -2.16935
SDHD succinate dehydrogenase complex, subunit D, integral membrane protein -2.16685
AIM2 absent in melanoma 2 -2.1592
CCNB2 cyclin B2 -2.1572
GPR171 G protein-coupled receptor 171 -2.15555
LIME1 Lck interacting transmembrane adaptor 1 -2.15495
MRPL4 mitochondrial ribosomal protein L4 -2.1534
DYSF dysferlin -2.14745
CCNC cyclin C -2.1471
MT1X metallothionein 1X -2.14338
RSAD2 radical S-adenosyl methionine domain containing 2 -2.14325
TKT transketolase -2.1431
PRRX2 paired related homeobox 2 -2.1308
IFI44 interferon-induced protein 44 -2.11583
PPP1R1A protein phosphatase 1, regulatory (inhibitor) subunit 1A -2.11025
BHMT betaine--homocysteine S-methyltransferase -2.1049
BCL7C B-cell CLL/lymphoma 7C -2.10305
GPR6 G protein-coupled receptor 6 -2.1029
STAT4 signal transducer and activator of transcription 4 -2.09695
C1QB complement component 1, q subcomponent, B chain -2.0858
BCL2L14 BCL2-like 14 (apoptosis facilitator) -2.0857
SHMT1 serine hydroxymethyltransferase 1 (soluble) -2.08395
TNFSF10 tumor necrosis factor (ligand) superfamily, member 10 -2.08213
MGAT4C MGAT4 family, member C -2.0776
CAMTA1 calmodulin binding transcription activator 1 -2.06755
FSCN3 fascin actin-bundling protein 3, testicular -2.05795
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) -2.05443
CANT1 calcium activated nucleotidase 1 -2.05035
HHEX hematopoietically expressed homeobox -2.0472
PRKCG protein kinase C, gamma -2.0467
CLDN8 claudin 8 -2.04325
HAO2 hydroxyacid oxidase 2 (long chain) -2.0423
CCL19 chemokine (C-C motif) ligand 19 -2.0415
BRME1 break repair meiotic recombinase recruitment factor 1 -2.0412
HTN3 histatin 3 -2.0405
CBR3 carbonyl reductase 3 -2.0376
CCDC198 coiled-coil domain containing 198 -2.03
BIRC5 baculoviral IAP repeat containing 5 -2.02798
ALDH8A1 aldehyde dehydrogenase 8 family, member A1 -2.0276
YJU2 YJU2 splicing factor homolog -2.0275
FOXM1 forkhead box M1 -2.02595
SLC68A1 solute carrier family 68 member 1 -2.01985
PERP PERP, TP53 apoptosis effector -2.01935
EDN1 endothelin 1 -2.0191
CLCNKB chloride channel, voltage-sensitive Kb -2.0187
STK26 serine/threonine protein kinase 26 -2.0173
MRPL46 mitochondrial ribosomal protein L46 -2.0166
UGT8 UDP glycosyltransferase 8 -2.0047
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.00315