CRCGN017_MCF10A.TP53.M_24H:E03 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phosphonium sulfate 11.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

179 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:E03 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 5.65576
E2F2 E2F transcription factor 2 5.21383
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 5.09386
MCOLN1 mucolipin 1 5.06218
GATA2 GATA binding protein 2 5.0066
MAMLD1 mastermind-like domain containing 1 5.00564
RAB11FIP2 RAB11 family interacting protein 2 (class I) 4.77476
AMDHD2 amidohydrolase domain containing 2 4.62207
COMP cartilage oligomeric matrix protein 4.42195
RALA v-ral simian leukemia viral oncogene homolog A (ras related) 3.48834
LILRB5 leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 5 3.45135
NR0B1 nuclear receptor subfamily 0, group B, member 1 3.13642
SIGLEC1 sialic acid binding Ig-like lectin 1, sialoadhesin 3.10264
REG3A regenerating islet-derived 3 alpha 3.01964
AGR2 anterior gradient 2 2.97658
AKR1C3 aldo-keto reductase family 1, member C3 2.93312
GBA1 glucosylceramidase beta 1 2.90645
TENT5C terminal nucleotidyltransferase 5C 2.87336
CD8A CD8a molecule 2.78615
STEEP1 STING1 ER exit protein 1 2.71193
CHRDL1 chordin-like 1 2.67942
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.65627
KLRC3 killer cell lectin-like receptor subfamily C, member 3 2.63837
DNM2 dynamin 2 2.61664
ACP5 acid phosphatase 5, tartrate resistant 2.58379
PRSS58 protease, serine, 58 2.57079
MBNL3 muscleblind-like splicing regulator 3 2.55901
LOC124907090 ankyrin repeat domain-containing protein SOWAHC-like 2.54496
KLRC4 killer cell lectin-like receptor subfamily C, member 4 2.53222
INS insulin 2.51222
LPCAT1 lysophosphatidylcholine acyltransferase 1 2.49965
CD244 CD244 molecule, natural killer cell receptor 2B4 2.49755
CTSW cathepsin W 2.48841
PTPRJ protein tyrosine phosphatase, receptor type, J 2.4857
ADRB2 adrenoceptor beta 2, surface 2.47393
KLRC1 killer cell lectin-like receptor subfamily C, member 1 2.45497
REG1B regenerating islet-derived 1 beta 2.42129
TPSAB1 tryptase alpha/beta 1 2.41267
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.40673
CPA1 carboxypeptidase A1 (pancreatic) 2.40171
PALMD palmdelphin 2.39934
LGMN legumain 2.37494
CRYBA2 crystallin, beta A2 2.36971
PNLIP pancreatic lipase 2.36951
PLA2G1B phospholipase A2, group IB (pancreas) 2.35903
TBPL1 TBP-like 1 2.34808
ARAF A-Raf proto-oncogene, serine/threonine kinase 2.3251
MRC1 mannose receptor, C type 1 2.31884
PTCD1 pentatricopeptide repeat domain 1 2.31501
PPP2R2D protein phosphatase 2, regulatory subunit B, delta 2.30895
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.30847
CPA4 carboxypeptidase A4 2.30482
CD8B CD8b molecule 2.29939
CELA3B chymotrypsin-like elastase family, member 3B 2.29476
ERV3-1-ZNF117 ERV3-1-ZNF117 readthrough 2.29307
H2AC7 H2A clustered histone 7 2.29113
MAGEC2 melanoma antigen family C2 2.28696
VCPIP1 valosin containing protein (p97)/p47 complex interacting protein 1 2.28667
ARSA arylsulfatase A 2.28389
CELA2A chymotrypsin-like elastase family, member 2A 2.28207
PIP5K1B phosphatidylinositol-4-phosphate 5-kinase, type I, beta 2.27388
MARCHF1 membrane associated ring-CH-type finger 1 2.25363
EPHB6 EPH receptor B6 2.25328
COQ4 coenzyme Q4 2.25145
SLCO5A1 solute carrier organic anion transporter family, member 5A1 2.25101
VPS37B vacuolar protein sorting 37 homolog B (S. cerevisiae) 2.24307
STK10 serine/threonine kinase 10 2.24292
COA3 cytochrome c oxidase assembly factor 3 2.24196
H2AC19 H2A clustered histone 19 2.23744
CD7 CD7 molecule 2.23742
STAT4 signal transducer and activator of transcription 4 2.23449
SDC3 syndecan 3 2.23045
PARP11 poly (ADP-ribose) polymerase family, member 11 2.23039
SUCO SUN domain containing ossification factor 2.22719
MS4A4A membrane-spanning 4-domains, subfamily A, member 4A 2.21565
DPM3 dolichyl-phosphate mannosyltransferase polypeptide 3 2.21423
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.19923
ARL4A ADP-ribosylation factor-like 4A 2.19782
CYP11B1 cytochrome P450, family 11, subfamily B, polypeptide 1 2.1978
MSTN myostatin 2.19713
LAMA5 laminin, alpha 5 2.18983
ANKRD36C ankyrin repeat domain 36C 2.18163
LGSN lengsin, lens protein with glutamine synthetase domain 2.17945
TARP TCR gamma alternate reading frame protein 2.17149
RAPGEF1 Rap guanine nucleotide exchange factor (GEF) 1 2.16756
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.1601
RAMP1 receptor (G protein-coupled) activity modifying protein 1 2.15783
ZNF75D zinc finger protein 75D 2.15107
VAX2 ventral anterior homeobox 2 2.1497
ITPR2 inositol 1,4,5-trisphosphate receptor, type 2 2.14966
HIP1R huntingtin interacting protein 1 related 2.13695
CCR6 chemokine (C-C motif) receptor 6 2.13512
CRTAM cytotoxic and regulatory T cell molecule 2.13077
GMPR guanosine monophosphate reductase 2.12995
PAX9 paired box 9 2.12964
LAMC3 laminin, gamma 3 2.1256
ADA2 adenosine deaminase 2 2.1248
CD160 CD160 molecule 2.12374
ARMCX6 armadillo repeat containing, X-linked 6 2.11983
TSPAN13 tetraspanin 13 2.11519
FGF12 fibroblast growth factor 12 2.10585
CELA2B chymotrypsin-like elastase family, member 2B 2.10541
VGLL3 vestigial-like family member 3 2.09829
MAP3K14 mitogen-activated protein kinase kinase kinase 14 2.09576
ZNF559-ZNF177 ZNF559-ZNF177 readthrough 2.09533
OSTM1 osteopetrosis associated transmembrane protein 1 2.09253
ABI3BP ABI family, member 3 (NESH) binding protein 2.07998
ZNF711 zinc finger protein 711 2.07992
DLL3 delta-like 3 (Drosophila) 2.07378
CTRB1 chymotrypsinogen B1 2.06998
EIF2B1 eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa 2.06902
HPSE heparanase 2.06504
KAT6B K(lysine) acetyltransferase 6B 2.06446
OTOR otoraplin 2.06411
SGCG sarcoglycan, gamma (35kDa dystrophin-associated glycoprotein) 2.06087
FAM110B family with sequence similarity 110, member B 2.0486
IL5 interleukin 5 2.04645
PPCDC phosphopantothenoylcysteine decarboxylase 2.04077
AOC3 amine oxidase, copper containing 3 2.03896
ABHD11 abhydrolase domain containing 11 2.03392
FBXL8 F-box and leucine-rich repeat protein 8 2.02288
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.02277
PNPLA6 patatin-like phospholipase domain containing 6 2.02134
PDCD6 programmed cell death 6 2.01833
SAR1A secretion associated, Ras related GTPase 1A 2.01794
SERPINI2 serpin peptidase inhibitor, clade I (pancpin), member 2 2.01568
SULT2A1 sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1 2.0143
GUK1 guanylate kinase 1 2.01276
ZFYVE26 zinc finger, FYVE domain containing 26 2.01156
ZNF254 zinc finger protein 254 2.00358
HAUS3 HAUS augmin-like complex, subunit 3 2.00096
CYB5R3 cytochrome b5 reductase 3 2.00076

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -5.77337
KRT14 keratin 14, type I -5.2913
SLC35F2 solute carrier family 35, member F2 -5.12234
CAB39 calcium binding protein 39 -4.8863
GTPBP8 GTP-binding protein 8 (putative) -4.47381
TXNDC9 thioredoxin domain containing 9 -4.3545
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -4.31859
CD58 CD58 molecule -3.97665
PIH1D1 PIH1 domain containing 1 -3.67114
IGFBP7 insulin-like growth factor binding protein 7 -3.28417
GMPR2 guanosine monophosphate reductase 2 -3.0595
MSN moesin -2.89081
COTL1 coactosin-like F-actin binding protein 1 -2.84032
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.8321
S100A2 S100 calcium binding protein A2 -2.66263
SERPINH1 serpin peptidase inhibitor, clade H (heat shock protein 47), member 1, (collagen binding protein 1) -2.64193
MAP2K1 mitogen-activated protein kinase kinase 1 -2.54152
GOLPH3L golgi phosphoprotein 3-like -2.48313
QARS1 glutaminyl-tRNA synthetase 1 -2.4326
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.42494
TLK2 tousled-like kinase 2 -2.36038
TNFAIP3 tumor necrosis factor, alpha-induced protein 3 -2.33712
CLNS1A chloride channel, nucleotide-sensitive, 1A -2.26213
TRIM22 tripartite motif containing 22 -2.23809
LMO2 LIM domain only 2 (rhombotin-like 1) -2.22385
TFEB transcription factor EB -2.21834
VOPP1 vesicular, overexpressed in cancer, prosurvival protein 1 -2.18166
PADI2 peptidyl arginine deiminase, type II -2.17523
LPGAT1 lysophosphatidylglycerol acyltransferase 1 -2.16888
SUMF2 sulfatase modifying factor 2 -2.13243
PTPN9 protein tyrosine phosphatase, non-receptor type 9 -2.1278
DNAJC5 DnaJ (Hsp40) homolog, subfamily C, member 5 -2.11453
CMPK1 cytidine monophosphate (UMP-CMP) kinase 1, cytosolic -2.11295
HAUS4 HAUS augmin-like complex, subunit 4 -2.10472
MYL6B myosin, light chain 6B, alkali, smooth muscle and non-muscle -2.0924
DDB2 damage-specific DNA binding protein 2, 48kDa -2.09215
LMAN2L lectin, mannose-binding 2-like -2.08322
DUSP14 dual specificity phosphatase 14 -2.07076
COL4A1 collagen, type IV, alpha 1 -2.06439
AGPS alkylglycerone phosphate synthase -2.05469
PDHB pyruvate dehydrogenase (lipoamide) beta -2.03999
XKR8 XK, Kell blood group complex subunit-related family, member 8 -2.03647
PARP2 poly (ADP-ribose) polymerase 2 -2.01639
DEK DEK proto-oncogene -2.01189
F3 coagulation factor III (thromboplastin, tissue factor) -2.01092
B4GALT4 UDP-Gal:betaGlcNAc beta 1,4- galactosyltransferase, polypeptide 4 -2.00602
SFXN1 sideroflexin 1 -2.00071