CRCGN017_MCF10A.TP53.M_24H:E05 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 34.5 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

285 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:E05 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PDLIM1 PDZ and LIM domain 1 5.20756
HMOX1 heme oxygenase 1 4.89046
TNIP1 TNFAIP3 interacting protein 1 4.74859
UGDH UDP-glucose 6-dehydrogenase 4.33542
OXSR1 oxidative stress responsive 1 4.29416
TCEA2 transcription elongation factor A (SII), 2 4.0235
RGS2 regulator of G-protein signaling 2 3.71126
AGR2 anterior gradient 2 3.67462
TICAM1 toll-like receptor adaptor molecule 1 3.62945
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 3.57577
DNAJB2 DnaJ (Hsp40) homolog, subfamily B, member 2 3.54411
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 3.52586
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 3.44835
ALAS1 5'-aminolevulinate synthase 1 3.44387
CTSL cathepsin L 3.39103
CASP2 caspase 2, apoptosis-related cysteine peptidase 3.37675
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 3.36768
STAP2 signal transducing adaptor family member 2 3.32537
IFI6 interferon, alpha-inducible protein 6 3.19093
PSMD2 proteasome (prosome, macropain) 26S subunit, non-ATPase, 2 3.1013
PARP12 poly (ADP-ribose) polymerase family, member 12 3.08032
PTPN1 protein tyrosine phosphatase, non-receptor type 1 3.06742
SQSTM1 sequestosome 1 3.04626
ADRB2 adrenoceptor beta 2, surface 2.96978
DDA1 DET1 and DDB1 associated 1 2.89771
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 2.83334
CNRIP1 cannabinoid receptor interacting protein 1 2.82251
TIMM17B translocase of inner mitochondrial membrane 17 homolog B (yeast) 2.81704
MYH9 myosin, heavy chain 9, non-muscle 2.7826
TMEM131 transmembrane protein 131 2.74837
ARHGEF2 Rho/Rac guanine nucleotide exchange factor (GEF) 2 2.71611
SSR3 signal sequence receptor, gamma (translocon-associated protein gamma) 2.71333
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.70608
LGALSL lectin, galactoside-binding-like 2.65741
MSRA methionine sulfoxide reductase A 2.65526
RBBP5 retinoblastoma binding protein 5 2.6384
ARHGEF18 Rho/Rac guanine nucleotide exchange factor (GEF) 18 2.61812
DUSP14 dual specificity phosphatase 14 2.61124
MVP major vault protein 2.61023
SLC35A3 solute carrier family 35 (UDP-N-acetylglucosamine (UDP-GlcNAc) transporter), member A3 2.60248
FHL2 four and a half LIM domains 2 2.59954
MCOLN1 mucolipin 1 2.58634
SQOR sulfide quinone oxidoreductase 2.58591
RAB8A RAB8A, member RAS oncogene family 2.58409
AMOTL2 angiomotin like 2 2.4745
IQGAP1 IQ motif containing GTPase activating protein 1 2.42022
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 2.41683
PLA2G15 phospholipase A2, group XV 2.37252
DDX27 DEAD (Asp-Glu-Ala-Asp) box polypeptide 27 2.37205
TTPAL tocopherol (alpha) transfer protein-like 2.36678
ARHGAP17 Rho GTPase activating protein 17 2.35711
SYNGAP1 synaptic Ras GTPase activating protein 1 2.34908
ZMPSTE24 zinc metallopeptidase STE24 2.33295
EHD1 EH-domain containing 1 2.33204
SCAF8 SR-related CTD-associated factor 8 2.3195
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A 2.31927
UBQLN2 ubiquilin 2 2.31346
CHPF2 chondroitin polymerizing factor 2 2.31163
TXNRD1 thioredoxin reductase 1 2.30814
TOMM34 translocase of outer mitochondrial membrane 34 2.29942
PLSCR3 phospholipid scramblase 3 2.29576
UPF1 UPF1 regulator of nonsense transcripts homolog (yeast) 2.29167
SERPINB7 serpin peptidase inhibitor, clade B (ovalbumin), member 7 2.28841
CAP1 CAP, adenylate cyclase-associated protein 1 (yeast) 2.28023
CIAO2B cytosolic iron-sulfur assembly component 2B 2.2684
CSNK1E casein kinase 1, epsilon 2.26104
ACTN4 actinin, alpha 4 2.25867
FSTL3 follistatin-like 3 (secreted glycoprotein) 2.24862
NDEL1 nudE neurodevelopment protein 1-like 1 2.22516
LRP10 low density lipoprotein receptor-related protein 10 2.21898
PPP1R11 protein phosphatase 1, regulatory (inhibitor) subunit 11 2.21349
VAT1 vesicle amine transport 1 2.20318
PLEC plectin 2.20273
HECTD3 HECT domain containing E3 ubiquitin protein ligase 3 2.1905
STT3A STT3A, subunit of the oligosaccharyltransferase complex (catalytic) 2.19034
EIF2S3 eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa 2.17689
PIAS3 protein inhibitor of activated STAT, 3 2.17417
OSTF1 osteoclast stimulating factor 1 2.16602
FOXD1 forkhead box D1 2.16338
BAG3 BCL2-associated athanogene 3 2.16305
ATP13A1 ATPase type 13A1 2.15849
TIMM10B translocase of inner mitochondrial membrane 10 homolog B (yeast) 2.13959
LGALS9C lectin, galactoside-binding, soluble, 9C 2.13716
IL1B interleukin 1, beta 2.1329
IER5 immediate early response 5 2.12824
TMEM50A transmembrane protein 50A 2.1211
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.11688
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.1084
EPB41L4B erythrocyte membrane protein band 4.1 like 4B 2.09145
GNG5 guanine nucleotide binding protein (G protein), gamma 5 2.08427
CEMIP2 cell migration inducing hyaluronidase 2 2.08033
PMP22 peripheral myelin protein 22 2.07959
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.07527
KRT34 keratin 34, type I 2.06106
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.05719
PSEN2 presenilin 2 2.05662
TUFT1 tuftelin 1 2.04677
TMEM40 transmembrane protein 40 2.04673
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 2.0406
MX1 MX dynamin-like GTPase 1 2.02979
KDM5A lysine (K)-specific demethylase 5A 2.02836
ZNF638 zinc finger protein 638 2.02008
CDPF1 cysteine-rich, DPF motif domain containing 1 2.01956
SERPINB2 serpin peptidase inhibitor, clade B (ovalbumin), member 2 2.00836
CDK9 cyclin-dependent kinase 9 2.00504
PUM3 pumilio RNA binding family member 3 2.00421
IL4R interleukin 4 receptor 2.00267
MNT MAX network transcriptional repressor 2.0017

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -5.86716
DCK deoxycytidine kinase -5.74471
NLRP4 NLR family, pyrin domain containing 4 -5.28254
CCNB1 cyclin B1 -4.82885
CCNB2 cyclin B2 -4.58477
PSRC1 proline/serine-rich coiled-coil 1 -4.55736
TOP2A topoisomerase (DNA) II alpha 170kDa -4.54972
NUSAP1 nucleolar and spindle associated protein 1 -4.50943
CDK1 cyclin-dependent kinase 1 -4.43842
PARPBP PARP1 binding protein -4.3248
HADH hydroxyacyl-CoA dehydrogenase -4.24371
CDCA3 cell division cycle associated 3 -4.20024
OXCT1 3-oxoacid CoA transferase 1 -4.10732
HOXA5 homeobox A5 -4.09164
KIF11 kinesin family member 11 -3.88859
STMN1 stathmin 1 -3.83128
B4GAT1 beta-1,4-glucuronyltransferase 1 -3.79121
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.71172
CENPA centromere protein A -3.70184
CDC45 cell division cycle 45 -3.68458
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.64706
OIP5 Opa interacting protein 5 -3.57608
CCNA2 cyclin A2 -3.55325
AURKB aurora kinase B -3.51837
RPA3 replication protein A3, 14kDa -3.46267
LYPLA1 lysophospholipase I -3.45698
FBXO5 F-box protein 5 -3.45464
NEIL3 nei endonuclease VIII-like 3 (E. coli) -3.37318
PBK PDZ binding kinase -3.27094
KIF18A kinesin family member 18A -3.24898
ANKRD10 ankyrin repeat domain 10 -3.24526
DEPDC1 DEP domain containing 1 -3.23141
SPC25 SPC25, NDC80 kinetochore complex component -3.19413
SESN1 sestrin 1 -3.16691
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.16291
CDKN3 cyclin-dependent kinase inhibitor 3 -3.15919
KIF23 kinesin family member 23 -3.13589
TROAP trophinin associated protein -3.12462
FOXM1 forkhead box M1 -3.12108
DDB2 damage-specific DNA binding protein 2, 48kDa -3.10694
BIRC5 baculoviral IAP repeat containing 5 -3.08433
KIF4A kinesin family member 4A -3.05595
KIF20A kinesin family member 20A -3.02502
HJURP Holliday junction recognition protein -3.02253
NEK2 NIMA-related kinase 2 -3.02026
CDC25C cell division cycle 25C -3.01321
NCAPH non-SMC condensin I complex, subunit H -3.00883
MXD3 MAX dimerization protein 3 -2.99614
MPHOSPH9 M-phase phosphoprotein 9 -2.9742
PLK1 polo-like kinase 1 -2.95585
TTK TTK protein kinase -2.94197
MYBL2 v-myb avian myeloblastosis viral oncogene homolog-like 2 -2.94185
CKAP2 cytoskeleton associated protein 2 -2.92279
HAUS4 HAUS augmin-like complex, subunit 4 -2.92277
NDC80 NDC80 kinetochore complex component -2.91312
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit -2.90273
SKA1 spindle and kinetochore associated complex subunit 1 -2.89445
RACGAP1 Rac GTPase activating protein 1 -2.86121
GINS1 GINS complex subunit 1 (Psf1 homolog) -2.85616
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.83931
GPR19 G protein-coupled receptor 19 -2.79477
MRPS16 mitochondrial ribosomal protein S16 -2.79423
YEATS4 YEATS domain containing 4 -2.79227
DSCC1 DNA replication and sister chromatid cohesion 1 -2.74896
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.748
KNTC1 kinetochore associated 1 -2.70027
DHFR dihydrofolate reductase -2.6831
MKI67 marker of proliferation Ki-67 -2.65398
NCAPG2 non-SMC condensin II complex, subunit G2 -2.64512
ITGB3BP integrin beta 3 binding protein (beta3-endonexin) -2.62943
CDC7 cell division cycle 7 -2.62252
INTS14 integrator complex subunit 14 -2.61022
AUNIP aurora kinase A and ninein interacting protein -2.60821
MAD2L1 MAD2 mitotic arrest deficient-like 1 (yeast) -2.59441
ERCC6L excision repair cross-complementation group 6-like -2.58405
PLK4 polo-like kinase 4 -2.5718
ZNF267 zinc finger protein 267 -2.56863
ASF1B anti-silencing function 1B histone chaperone -2.56445
LBR lamin B receptor -2.56095
MKKS McKusick-Kaufman syndrome -2.5567
CENPS-CORT CENPS-CORT readthrough -2.52483
RAD51AP1 RAD51 associated protein 1 -2.52035
CENPE centromere protein E, 312kDa -2.50976
TCTN1 tectonic family member 1 -2.49821
TACC3 transforming, acidic coiled-coil containing protein 3 -2.49189
KIF15 kinesin family member 15 -2.48807
EMC9 ER membrane protein complex subunit 9 -2.47449
KANSL1 KAT8 regulatory NSL complex subunit 1 -2.45969
BCAP31 B-cell receptor-associated protein 31 -2.44106
LYPLA1-TCEA1 LYPLA1-TCEA1 readthrough -2.43907
TM9SF3 transmembrane 9 superfamily member 3 -2.4362
CCNF cyclin F -2.43408
GPN3 GPN-loop GTPase 3 -2.43407
HMGN5 high mobility group nucleosome binding domain 5 -2.42431
COPS7A COP9 signalosome subunit 7A -2.41868
CBX3 chromobox homolog 3 -2.39432
BRCA1 breast cancer 1, early onset -2.39416
PCBD1 pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha -2.38343
PSIP1 PC4 and SFRS1 interacting protein 1 -2.37552
CENPF centromere protein F, 350/400kDa -2.37409
E2F8 E2F transcription factor 8 -2.37059
PSAT1 phosphoserine aminotransferase 1 -2.36967
CT55 cancer/testis antigen 55 -2.369
XPOT exportin, tRNA -2.35666
FASN fatty acid synthase -2.34748
DNA2 DNA replication helicase/nuclease 2 -2.34679
PSPH phosphoserine phosphatase -2.34447
EXO1 exonuclease 1 -2.34368
HOXB3 homeobox B3 -2.34021
CENPI centromere protein I -2.32816
CETN3 centrin, EF-hand protein, 3 -2.32228
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -2.31636
EZH2 enhancer of zeste 2 polycomb repressive complex 2 subunit -2.31565
FANCI Fanconi anemia, complementation group I -2.30916
SUV39H1 suppressor of variegation 3-9 homolog 1 (Drosophila) -2.30422
NPM3 nucleophosmin/nucleoplasmin 3 -2.29192
CEP55 centrosomal protein 55kDa -2.28704
RMI1 RecQ mediated genome instability 1 -2.28434
METTL4 methyltransferase like 4 -2.27403
FIRRM FIGNL1 interacting regulator of recombination and mitosis -2.27225
NUP85 nucleoporin 85kDa -2.26409
PHGDH phosphoglycerate dehydrogenase -2.25542
ARHGAP11A Rho GTPase activating protein 11A -2.2482
RFC5 replication factor C (activator 1) 5, 36.5kDa -2.24307
PTEN phosphatase and tensin homolog -2.24262
TAFAZZIN tafazzin, phospholipid-lysophospholipid transacylase -2.23511
RPL10L ribosomal protein L10-like -2.23327
COQ3 coenzyme Q3 methyltransferase -2.2275
POLE polymerase (DNA directed), epsilon, catalytic subunit -2.21744
IPCEF1 interaction protein for cytohesin exchange factors 1 -2.21006
SEPHS1 selenophosphate synthetase 1 -2.20705
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.20451
ZNF217 zinc finger protein 217 -2.20435
CDCA4 cell division cycle associated 4 -2.20065
PCLAF PCNA clamp associated factor -2.19969
ZNF384 zinc finger protein 384 -2.19643
GTSE1 G-2 and S-phase expressed 1 -2.19412
TMEM187 transmembrane protein 187 -2.19357
KIF20B kinesin family member 20B -2.18781
BORA bora, aurora kinase A activator -2.184
SMC4 structural maintenance of chromosomes 4 -2.17508
NUP43 nucleoporin 43kDa -2.17476
EVI2B ecotropic viral integration site 2B -2.17141
SKI SKI proto-oncogene -2.16609
WDHD1 WD repeat and HMG-box DNA binding protein 1 -2.16538
PMCH pro-melanin-concentrating hormone -2.15855
STIL SCL/TAL1 interrupting locus -2.14968
KIF18B kinesin family member 18B -2.14443
PIH1D1 PIH1 domain containing 1 -2.14245
PMS1 PMS1 postmeiotic segregation increased 1 (S. cerevisiae) -2.12444
APIP APAF1 interacting protein -2.1237
ATAD2 ATPase family, AAA domain containing 2 -2.12128
ATL2 atlastin GTPase 2 -2.11782
CPAP centrosome assembly and centriole elongation protein -2.11451
CD320 CD320 molecule -2.09931
NUCKS1 nuclear casein kinase and cyclin-dependent kinase substrate 1 -2.09691
NUP42 nucleoporin 42 -2.0856
PDIA2 protein disulfide isomerase family A, member 2 -2.08339
LETMD1 LETM1 domain containing 1 -2.07745
TRIB3 tribbles pseudokinase 3 -2.07688
PSMC3IP PSMC3 interacting protein -2.07396
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -2.07288
EMID1 EMI domain containing 1 -2.06896
DEK DEK proto-oncogene -2.06203
DUT deoxyuridine triphosphatase -2.05588
HELLS helicase, lymphoid-specific -2.05378
NCAPD2 non-SMC condensin I complex, subunit D2 -2.04399
RFWD3 ring finger and WD repeat domain 3 -2.04073
RAB33B RAB33B, member RAS oncogene family -2.03427
CPOX coproporphyrinogen oxidase -2.0264
UNC5B unc-5 homolog B (C. elegans) -2.02165
CYCS cytochrome c, somatic -2.01847
KRT86 keratin 86, type II -2.01538
NUDT6 nudix (nucleoside diphosphate linked moiety X)-type motif 6 -2.00999
CAMK4 calcium/calmodulin-dependent protein kinase IV -2.00932
CETN2 centrin, EF-hand protein, 2 -2.00773
GMNN geminin, DNA replication inhibitor -2.0026