CRCGN017_MCF10A.TP53.M_24H:E06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5h)-furanone 11.5 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

15 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:E06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 4.91742
INTS3 integrator complex subunit 3 3.94188
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase 3.56152
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.6669
CNPY3 canopy FGF signaling regulator 3 2.54818
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 2.51587
CCL2 chemokine (C-C motif) ligand 2 2.37419
TPD52L2 tumor protein D52-like 2 2.21708
TCEA2 transcription elongation factor A (SII), 2 2.08759

decreased expression

Symbol Name Standardized Value
CCNB1 cyclin B1 -5.86674
NPDC1 neural proliferation, differentiation and control, 1 -3.54227
KDM3A lysine (K)-specific demethylase 3A -2.22691
TOR1A torsin family 1, member A (torsin A) -2.22388
IQGAP1 IQ motif containing GTPase activating protein 1 -2.0222
DCK deoxycytidine kinase -2.01532