CRCGN017_MCF10A.TP53.M_24H:E11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description endosulfan 33.66 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

236 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:E11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
IL1B interleukin 1, beta 5.29187
STX1A syntaxin 1A (brain) 4.83696
CDCA4 cell division cycle associated 4 4.54033
NR3C1 nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) 4.38569
SERPINE1 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 4.30059
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.26472
SYNGAP1 synaptic Ras GTPase activating protein 1 3.7838
FHL2 four and a half LIM domains 2 3.65924
NRIP1 nuclear receptor interacting protein 1 3.46496
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.43541
GATA3 GATA binding protein 3 3.36503
FOSL1 FOS-like antigen 1 3.28306
TBC1D31 TBC1 domain family, member 31 3.2279
COL4A1 collagen, type IV, alpha 1 3.17946
STK10 serine/threonine kinase 10 3.09554
SSBP2 single-stranded DNA binding protein 2 3.02357
HMGA2 high mobility group AT-hook 2 3.00722
LIMA1 LIM domain and actin binding 1 2.92608
TSKU tsukushi, small leucine rich proteoglycan 2.87764
EGR1 early growth response 1 2.81646
HOXA5 homeobox A5 2.76946
G0S2 G0/G1 switch 2 2.69036
S100A7 S100 calcium binding protein A7 2.62867
ACOT9 acyl-CoA thioesterase 9 2.6282
KCTD5 potassium channel tetramerization domain containing 5 2.57692
COL4A2 collagen, type IV, alpha 2 2.533
MARK3 MAP/microtubule affinity-regulating kinase 3 2.44931
PLEK2 pleckstrin 2 2.43542
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 2.43452
ZNF143 zinc finger protein 143 2.43193
TMEM109 transmembrane protein 109 2.40505
NUCB2 nucleobindin 2 2.34781
GPHRA golgi pH regulator A 2.34743
PYGL phosphorylase, glycogen, liver 2.34541
CCL2 chemokine (C-C motif) ligand 2 2.34216
LAMB3 laminin, beta 3 2.34059
NPIPB6 nuclear pore complex interacting protein family, member B6 2.3293
FIP1L1 factor interacting with PAPOLA and CPSF1 2.3208
EIF4H eukaryotic translation initiation factor 4H 2.32078
IL1A interleukin 1, alpha 2.3115
PNKP polynucleotide kinase 3'-phosphatase 2.3036
PTHLH parathyroid hormone-like hormone 2.28455
GTF2E2 general transcription factor IIE, polypeptide 2, beta 34kDa 2.28137
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) 2.27381
BMS1 BMS1 ribosome biogenesis factor 2.27075
SERTAD2 SERTA domain containing 2 2.26292
TRIB1 tribbles pseudokinase 1 2.24804
IER3 immediate early response 3 2.2388
FXYD5 FXYD domain containing ion transport regulator 5 2.2335
ARMCX5 armadillo repeat containing, X-linked 5 2.22969
TRAPPC4 trafficking protein particle complex 4 2.22009
DUSP6 dual specificity phosphatase 6 2.21206
UBE3C ubiquitin protein ligase E3C 2.20618
SPINK2 serine peptidase inhibitor, Kazal type 2 (acrosin-trypsin inhibitor) 2.19793
PTER phosphotriesterase related 2.19006
TRIP6 thyroid hormone receptor interactor 6 2.18373
KRT6B keratin 6B, type II 2.17964
EGR3 early growth response 3 2.15909
RPL36A ribosomal protein L36a 2.15675
BHLHE40 basic helix-loop-helix family, member e40 2.155
SERPINE2 serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 2 2.14664
TXNDC5 thioredoxin domain containing 5 (endoplasmic reticulum) 2.14651
MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 2.14285
DUSP4 dual specificity phosphatase 4 2.14229
TYR tyrosinase 2.12071
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 2.12053
ACAA1 acetyl-CoA acyltransferase 1 2.12046
LRFN4 leucine rich repeat and fibronectin type III domain containing 4 2.11687
TBXT T-box transcription factor T 2.09892
PHLPP1 PH domain and leucine rich repeat protein phosphatase 1 2.08435
HOPX HOP homeobox 2.07959
HBEGF heparin-binding EGF-like growth factor 2.07936
EEF2 eukaryotic translation elongation factor 2 2.06402
DNAJC1 DnaJ (Hsp40) homolog, subfamily C, member 1 2.06245
CHIC2 cysteine-rich hydrophobic domain 2 2.05398
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 2.04402
MYO5A myosin VA (heavy chain 12, myoxin) 2.04314
IBTK inhibitor of Bruton agammaglobulinemia tyrosine kinase 2.03889
IER2 immediate early response 2 2.03222
GNG12 guanine nucleotide binding protein (G protein), gamma 12 2.03162
RANBP2 RAN binding protein 2 2.02804
JMJD1C jumonji domain containing 1C 2.0143
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.01376
FLNB filamin B, beta 2.01049
TCEA2 transcription elongation factor A (SII), 2 2.00802

decreased expression

Symbol Name Standardized Value
CHMP4B charged multivesicular body protein 4B -4.51618
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -4.51588
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -4.39672
FBXO21 F-box protein 21 -4.30082
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -4.02051
NSDHL NAD(P) dependent steroid dehydrogenase-like -3.87485
MSMO1 methylsterol monooxygenase 1 -3.76048
CIAPIN1 cytokine induced apoptosis inhibitor 1 -3.69785
PRR15L proline rich 15-like -3.66191
INSIG1 insulin induced gene 1 -3.52809
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.45964
CCNB1 cyclin B1 -3.45143
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.44135
AOPEP aminopeptidase O (putative) -3.31592
ZXDC ZXD family zinc finger C -3.17798
GOLT1B golgi transport 1B -3.15405
ADI1 acireductone dioxygenase 1 -3.14352
GRN granulin -3.11371
TMEM50B transmembrane protein 50B -3.08623
UBFD1 ubiquitin family domain containing 1 -3.054
ARL2BP ADP-ribosylation factor-like 2 binding protein -3.04463
SYNE2 spectrin repeat containing, nuclear envelope 2 -2.90265
TSPAN4 tetraspanin 4 -2.89825
HADH hydroxyacyl-CoA dehydrogenase -2.86844
PF4 platelet factor 4 -2.85664
CYB5B cytochrome b5 type B (outer mitochondrial membrane) -2.83355
PRKAR2B protein kinase, cAMP-dependent, regulatory, type II, beta -2.81798
PHKG2 phosphorylase kinase, gamma 2 (testis) -2.8068
DYNLT3 dynein, light chain, Tctex-type 3 -2.80618
ELOVL6 ELOVL fatty acid elongase 6 -2.78657
PRUNE2 prune homolog 2 (Drosophila) -2.72324
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.672
NDST3 N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 3 -2.6212
CIRBP cold inducible RNA binding protein -2.60954
DCAF11 DDB1 and CUL4 associated factor 11 -2.58609
KRT14 keratin 14, type I -2.56342
WDR73 WD repeat domain 73 -2.5539
PNPO pyridoxamine 5'-phosphate oxidase -2.52795
RCOR3 REST corepressor 3 -2.51698
HCK HCK proto-oncogene, Src family tyrosine kinase -2.51183
RPIA ribose 5-phosphate isomerase A -2.49127
HSPA1B heat shock 70kDa protein 1B -2.48372
C2CD5 C2 calcium-dependent domain containing 5 -2.48209
FECH ferrochelatase -2.46941
PRCP prolylcarboxypeptidase (angiotensinase C) -2.46489
HSD17B7 hydroxysteroid (17-beta) dehydrogenase 7 -2.46128
HPCA hippocalcin -2.44615
HSD17B11 hydroxysteroid (17-beta) dehydrogenase 11 -2.43511
SLC35E2B solute carrier family 35, member E2B -2.43272
ACHE acetylcholinesterase (Yt blood group) -2.42981
EEF1A2 eukaryotic translation elongation factor 1 alpha 2 -2.42013
PARM1 prostate androgen-regulated mucin-like protein 1 -2.40415
DNAJB1 DnaJ (Hsp40) homolog, subfamily B, member 1 -2.40366
EMC9 ER membrane protein complex subunit 9 -2.40345
MRPL49 mitochondrial ribosomal protein L49 -2.39838
ABHD4 abhydrolase domain containing 4 -2.38141
SLC2A6 solute carrier family 2 (facilitated glucose transporter), member 6 -2.37954
NUPR1 nuclear protein, transcriptional regulator, 1 -2.37628
IFT38 intraflagellar transport 38 -2.37619
MSLN mesothelin -2.37208
ZBTB16 zinc finger and BTB domain containing 16 -2.36961
NMRK1 nicotinamide riboside kinase 1 -2.35396
PSME1 proteasome (prosome, macropain) activator subunit 1 (PA28 alpha) -2.34845
RNF170 ring finger protein 170 -2.34529
SINHCAF SIN3-HDAC complex associated factor -2.34253
ATF5 activating transcription factor 5 -2.33297
DHCR24 24-dehydrocholesterol reductase -2.32829
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.31322
KRABD4 KRAB domain containing 4 -2.312
NOX1 NADPH oxidase 1 -2.30817
HSPH1 heat shock 105kDa/110kDa protein 1 -2.30713
PARD6A par-6 family cell polarity regulator alpha -2.2924
ITM2B integral membrane protein 2B -2.28648
WFDC1 WAP four-disulfide core domain 1 -2.27535
RAB5B RAB5B, member RAS oncogene family -2.26782
RPAP2 RNA polymerase II associated protein 2 -2.23632
GOLT1A golgi transport 1A -2.23492
ATP2A3 ATPase, Ca++ transporting, ubiquitous -2.21989
DNAJB4 DnaJ (Hsp40) homolog, subfamily B, member 4 -2.21829
CFP complement factor properdin -2.20722
RBFOX1 RNA binding protein, fox-1 homolog (C. elegans) 1 -2.19868
PSMB10 proteasome (prosome, macropain) subunit, beta type, 10 -2.19838
TRIM22 tripartite motif containing 22 -2.1917
GTF2IRD2B GTF2I repeat domain containing 2B -2.18807
GADD45B growth arrest and DNA-damage-inducible, beta -2.1878
PEX13 peroxisomal biogenesis factor 13 -2.18569
UTF1 undifferentiated embryonic cell transcription factor 1 -2.18418
FAM13B family with sequence similarity 13, member B -2.17719
PTPRN protein tyrosine phosphatase, receptor type, N -2.17658
OPLAH 5-oxoprolinase (ATP-hydrolysing) -2.17629
IPO8 importin 8 -2.17345
PSME2 proteasome (prosome, macropain) activator subunit 2 (PA28 beta) -2.17141
COXFA4 cytochrome c oxidase associated subunit FA4 -2.16546
SLC31A2 solute carrier family 31 (copper transporter), member 2 -2.16529
TRNAU1AP tRNA selenocysteine 1 associated protein 1 -2.16256
SCGB1D1 secretoglobin, family 1D, member 1 -2.16148
CYCS cytochrome c, somatic -2.15999
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 -2.15087
CLDN7 claudin 7 -2.1475
GDAP1 ganglioside induced differentiation associated protein 1 -2.14525
SOAT2 sterol O-acyltransferase 2 -2.14513
PTPRU protein tyrosine phosphatase, receptor type, U -2.13847
TULP3 tubby like protein 3 -2.13711
RPN1 ribophorin I -2.13564
FDXR ferredoxin reductase -2.12159
SUPV3L1 suppressor of var1, 3-like 1 (S. cerevisiae) -2.11715
TCTN1 tectonic family member 1 -2.11652
MTFR1 mitochondrial fission regulator 1 -2.11408
AGL amylo-alpha-1, 6-glucosidase, 4-alpha-glucanotransferase -2.11352
GP9 glycoprotein IX (platelet) -2.11294
PTH1R parathyroid hormone 1 receptor -2.1116
MPC1 mitochondrial pyruvate carrier 1 -2.10315
BANK1 B-cell scaffold protein with ankyrin repeats 1 -2.10161
GPR6 G protein-coupled receptor 6 -2.09998
GCH1 GTP cyclohydrolase 1 -2.0981
DDIT4 DNA-damage-inducible transcript 4 -2.09676
GFI1B growth factor independent 1B transcription repressor -2.0966
CCND3 cyclin D3 -2.0942
ALDOC aldolase C, fructose-bisphosphate -2.08197
KLK1 kallikrein 1 -2.08088
GREM2 gremlin 2, DAN family BMP antagonist -2.08047
IL1R1 interleukin 1 receptor, type I -2.07902
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -2.07724
BPHL biphenyl hydrolase-like (serine hydrolase) -2.07661
DOK4 docking protein 4 -2.07645
MFSD1 major facilitator superfamily domain containing 1 -2.07606
MCCC2 methylcrotonoyl-CoA carboxylase 2 (beta) -2.0701
RAI2 retinoic acid induced 2 -2.05869
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.05736
ICAM5 intercellular adhesion molecule 5, telencephalin -2.0562
SLC29A2 solute carrier family 29 (equilibrative nucleoside transporter), member 2 -2.05523
CEMIP cell migration inducing protein, hyaluronan binding -2.05337
DMTN dematin actin binding protein -2.05146
SMAD9 SMAD family member 9 -2.05075
HTR2C 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled -2.0461
DNM1L dynamin 1-like -2.04428
SLC35A5 solute carrier family 35, member A5 -2.04409
TWSG1 twisted gastrulation BMP signaling modulator 1 -2.04344
EHD3 EH-domain containing 3 -2.04108
SMIM29 small integral membrane protein 29 -2.03604
DPP3 dipeptidyl-peptidase 3 -2.03569
OSBP2 oxysterol binding protein 2 -2.03554
ZDHHC13 zinc finger, DHHC-type containing 13 -2.02973
TKT transketolase -2.0218
HSD11B2 hydroxysteroid (11-beta) dehydrogenase 2 -2.01645
PKP2 plakophilin 2 -2.01106
PDE2A phosphodiesterase 2A, cGMP-stimulated -2.00834
FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase) -2.00821
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 -2.00731
PLA2G12A phospholipase A2, group XIIA -2.00108
SGCE sarcoglycan, epsilon -2.00052