CRCGN017_MCF10A.TP53.M_24H:E12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description endosulfan 11.22 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

31 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:E12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 3.86603
USP7 ubiquitin specific peptidase 7 (herpes virus-associated) 3.22173
CTNNAL1 catenin (cadherin-associated protein), alpha-like 1 2.96275
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.61614
CXCL2 chemokine (C-X-C motif) ligand 2 2.5483
HMGA2 high mobility group AT-hook 2 2.32569
HOXA5 homeobox A5 2.19597
GATA3 GATA binding protein 3 2.1693
CAB39 calcium binding protein 39 2.16299

decreased expression

Symbol Name Standardized Value
MSMO1 methylsterol monooxygenase 1 -5.12417
DECR1 2,4-dienoyl CoA reductase 1, mitochondrial -4.21504
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.69553
RNF167 ring finger protein 167 -3.40568
COG4 component of oligomeric golgi complex 4 -3.31152
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.99205
TUBB6 tubulin, beta 6 class V -2.8848
CCNB1 cyclin B1 -2.80508
NT5DC2 5'-nucleotidase domain containing 2 -2.54061
NSDHL NAD(P) dependent steroid dehydrogenase-like -2.48043
PRR15L proline rich 15-like -2.47673
INSIG1 insulin induced gene 1 -2.39277
MVD mevalonate (diphospho) decarboxylase -2.2832
CYP2J2 cytochrome P450, family 2, subfamily J, polypeptide 2 -2.16177
MB myoglobin -2.14808
DHCR24 24-dehydrocholesterol reductase -2.1299
ALDOC aldolase C, fructose-bisphosphate -2.08724
UPB1 ureidopropionase, beta -2.07823
IRF9 interferon regulatory factor 9 -2.06579
KRT4 keratin 4, type II -2.05771
HSPB3 heat shock 27kDa protein 3 -2.037
RDH16 retinol dehydrogenase 16 (all-trans) -2.01047