CRCGN017_MCF10A.TP53.M_24H:E15 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description emodin 5.61 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:E15 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 4.80651
CXCR4 chemokine (C-X-C motif) receptor 4 4.2943
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.02845
AGR2 anterior gradient 2 3.43941
NFKBIE nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon 3.38231
BMP4 bone morphogenetic protein 4 3.2307
SPAG4 sperm associated antigen 4 2.59994
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.48932
DCUN1D4 DCN1, defective in cullin neddylation 1, domain containing 4 2.42959
ZMIZ1 zinc finger, MIZ-type containing 1 2.32322
NRBF2 nuclear receptor binding factor 2 2.31561
PCDHB11 protocadherin beta 11 2.24895
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.2465
PCK2 phosphoenolpyruvate carboxykinase 2 (mitochondrial) 2.03561

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -4.09611
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.71004
PCNA proliferating cell nuclear antigen -3.64032
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -3.62183
HSPA1A heat shock 70kDa protein 1A -2.76198
SAP30BP SAP30 binding protein -2.59522
SUMO4 small ubiquitin-like modifier 4 -2.50679
TUBA4A tubulin, alpha 4a -2.37582
KCTD2 potassium channel tetramerization domain containing 2 -2.37573
PSENEN presenilin enhancer gamma secretase subunit -2.31854
MRPS7 mitochondrial ribosomal protein S7 -2.29679
LDHD lactate dehydrogenase D -2.19821
TBCB tubulin folding cofactor B -2.14808
CTCF CCCTC-binding factor (zinc finger protein) -2.13074
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.13056
GPBP1L1 GC-rich promoter binding protein 1-like 1 -2.11888
GRB2 growth factor receptor-bound protein 2 -2.0815
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.05575
FDXR ferredoxin reductase -2.03107