CRCGN017_MCF10A.TP53.M_24H:E17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tetrakis(hydroxymethyl)phos-phonium chloride 33.82 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

122 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:E17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
NUCB2 nucleobindin 2 7.06611
TSEN2 TSEN2 tRNA splicing endonuclease subunit 4.13713
CXCL2 chemokine (C-X-C motif) ligand 2 4.09311
HBB hemoglobin, beta 3.89032
ABHD6 abhydrolase domain containing 6 3.34618
AMDHD2 amidohydrolase domain containing 2 3.20952
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 2.86304
CAPN1 calpain 1, (mu/I) large subunit 2.74536
ST8SIA4 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 4 2.72806
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.71826
TLR4 toll-like receptor 4 2.70926
MCUR1 mitochondrial calcium uniporter regulator 1 2.70838
DOCK2 dedicator of cytokinesis 2 2.59849
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.59526
CRELD2 cysteine-rich with EGF-like domains 2 2.57133
WDR5B WD repeat domain 5B 2.54562
GCLM glutamate-cysteine ligase, modifier subunit 2.54
DMXL2 Dmx-like 2 2.51578
RBKS ribokinase 2.48813
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.47893
MEGF9 multiple EGF-like-domains 9 2.45856
ALG12 ALG12, alpha-1,6-mannosyltransferase 2.45718
MGAT4B mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B 2.45555
TMEM9B TMEM9 domain family, member B 2.33061
JAKMIP2 janus kinase and microtubule interacting protein 2 2.32425
ARID5B AT rich interactive domain 5B (MRF1-like) 2.31229
INTS9 integrator complex subunit 9 2.30203
ADCY7 adenylate cyclase 7 2.29556
FARS2 phenylalanyl-tRNA synthetase 2, mitochondrial 2.26799
CYBB cytochrome b-245, beta polypeptide 2.25904
SLCO2B1 solute carrier organic anion transporter family, member 2B1 2.25098
TRADD TNFRSF1A-associated via death domain 2.23166
GSTA3 glutathione S-transferase alpha 3 2.22167
GMPPB GDP-mannose pyrophosphorylase B 2.21116
ADORA3 adenosine A3 receptor 2.19841
CYP11B2 cytochrome P450, family 11, subfamily B, polypeptide 2 2.1379
CLIP4 CAP-GLY domain containing linker protein family, member 4 2.13516
TMEM120B transmembrane protein 120B 2.13285
SEC22B SEC22 vesicle trafficking protein homolog B (S. cerevisiae) (gene/pseudogene) 2.11421
CTSO cathepsin O 2.10221
DCAF4 DDB1 and CUL4 associated factor 4 2.09894
APOL6 apolipoprotein L, 6 2.09308
BICRAL BICRA like chromatin remodeling complex associated protein 2.08502
SQSTM1 sequestosome 1 2.07951
MTHFSD methenyltetrahydrofolate synthetase domain containing 2.07502
PIK3C3 phosphatidylinositol 3-kinase, catalytic subunit type 3 2.05896
SLC16A2 solute carrier family 16, member 2 (thyroid hormone transporter) 2.05826
TSPAN8 tetraspanin 8 2.0523
CD40LG CD40 ligand 2.04733
CIAO2B cytosolic iron-sulfur assembly component 2B 2.04375
DCBLD2 discoidin, CUB and LCCL domain containing 2 2.04144
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 2.04138
ATG7 autophagy related 7 2.0411
ZNF23 zinc finger protein 23 2.04104
SAR1B secretion associated, Ras related GTPase 1B 2.03763
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 2.034
GPSM3 G-protein signaling modulator 3 2.02866
HTR2B 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled 2.01993
ZNF451 zinc finger protein 451 2.01828
CCNJL cyclin J-like 2.01347
TNFSF8 tumor necrosis factor (ligand) superfamily, member 8 2.01247
FAT4 FAT atypical cadherin 4 2.01189
SMPDL3A sphingomyelin phosphodiesterase, acid-like 3A 2.00961
FMNL1 formin-like 1 2.00067

decreased expression

Symbol Name Standardized Value
DNM1L dynamin 1-like -6.74904
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -6.30754
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -5.66434
KIF14 kinesin family member 14 -4.78096
KRT14 keratin 14, type I -4.19104
HAT1 histone acetyltransferase 1 -3.92089
INTS13 integrator complex subunit 13 -3.89952
NDC80 NDC80 kinetochore complex component -3.73465
TCTA T-cell leukemia translocation altered -3.46969
UBE2C ubiquitin-conjugating enzyme E2C -3.43554
HMG20B high mobility group 20B -3.33892
KDM3A lysine (K)-specific demethylase 3A -3.2888
SINHCAF SIN3-HDAC complex associated factor -3.16531
CCNB2 cyclin B2 -3.12376
AURKB aurora kinase B -3.05115
ACTR6 ARP6 actin-related protein 6 homolog (yeast) -2.97536
AURKA aurora kinase A -2.84137
CAB39 calcium binding protein 39 -2.76481
NEK2 NIMA-related kinase 2 -2.72515
CAPRIN2 caprin family member 2 -2.67116
TUBA4A tubulin, alpha 4a -2.64487
CDK1 cyclin-dependent kinase 1 -2.63161
MED21 mediator complex subunit 21 -2.62448
PSRC1 proline/serine-rich coiled-coil 1 -2.56194
CCDC91 coiled-coil domain containing 91 -2.53026
CHMP4B charged multivesicular body protein 4B -2.43779
RPAP3 RNA polymerase II associated protein 3 -2.43768
FAM32A family with sequence similarity 32, member A -2.42689
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.40208
SAE1 SUMO1 activating enzyme subunit 1 -2.38512
DDX11 DEAD/H (Asp-Glu-Ala-Asp/His) box helicase 11 -2.37211
FOXM1 forkhead box M1 -2.3136
ERGIC2 ERGIC and golgi 2 -2.31033
ITGA5 integrin, alpha 5 (fibronectin receptor, alpha polypeptide) -2.28854
PLK1 polo-like kinase 1 -2.26214
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -2.24789
CMAS cytidine monophosphate N-acetylneuraminic acid synthetase -2.22738
STIL SCL/TAL1 interrupting locus -2.22246
OFD1 oral-facial-digital syndrome 1 -2.2202
CCT8 chaperonin containing TCP1, subunit 8 (theta) -2.2151
CAND1 cullin-associated and neddylation-dissociated 1 -2.20884
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -2.19033
SPC25 SPC25, NDC80 kinetochore complex component -2.18927
TOP2A topoisomerase (DNA) II alpha 170kDa -2.18284
PGCKA1 PDCD10 and GCKIII kinases associated 1 -2.1763
NCAPH non-SMC condensin I complex, subunit H -2.16538
NPDC1 neural proliferation, differentiation and control, 1 -2.14303
RBM34 RNA binding motif protein 34 -2.14297
DBF4 DBF4 zinc finger -2.11049
KIF15 kinesin family member 15 -2.08438
KIF18A kinesin family member 18A -2.06654
DDX23 DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 -2.064
PARPBP PARP1 binding protein -2.06094
ANKRD10 ankyrin repeat domain 10 -2.05776
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) -2.04285
NUSAP1 nucleolar and spindle associated protein 1 -2.04208
KIF20A kinesin family member 20A -2.0352
UBE2S ubiquitin-conjugating enzyme E2S -2.00111