CRCGN017_MCF10A.TP53.M_24H:E22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-4-hydroxy-3-((4-sulfonatonaphthalen-1-yl)diazenyl)naphthalene-1-sulfonate 105.18 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

126 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:E22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CCP110 centriolar coiled coil protein 110kDa 5.49805
MAPKAPK5 mitogen-activated protein kinase-activated protein kinase 5 5.2839
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.94425
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 4.93525
SLC25A13 solute carrier family 25 (aspartate/glutamate carrier), member 13 4.55495
SPAG4 sperm associated antigen 4 4.45535
MSRA methionine sulfoxide reductase A 4.281
SLC25A14 solute carrier family 25 (mitochondrial carrier, brain), member 14 3.75125
IGHMBP2 immunoglobulin mu binding protein 2 3.23378
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 3.2161
PUS7L pseudouridylate synthase 7 homolog (S. cerevisiae)-like 3.0931
PAQR3 progestin and adipoQ receptor family member III 3.09275
ACAA1 acetyl-CoA acyltransferase 1 2.96443
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.76305
TIMP2 TIMP metallopeptidase inhibitor 2 2.7275
PIAS3 protein inhibitor of activated STAT, 3 2.65805
SLCO3A1 solute carrier organic anion transporter family, member 3A1 2.64028
AGTR1 angiotensin II receptor, type 1 2.62413
IRAK3 interleukin-1 receptor-associated kinase 3 2.62122
PTK2 protein tyrosine kinase 2 2.53842
TTLL7 tubulin tyrosine ligase-like family member 7 2.48825
PLPPR1 phospholipid phosphatase related 1 2.478
PDZD8 PDZ domain containing 8 2.4307
HSD17B3 hydroxysteroid (17-beta) dehydrogenase 3 2.41915
BRMS1L breast cancer metastasis-suppressor 1-like 2.41575
TPST1 tyrosylprotein sulfotransferase 1 2.40875
TBC1D16 TBC1 domain family, member 16 2.3704
MRPL11 mitochondrial ribosomal protein L11 2.35115
AUP1 ancient ubiquitous protein 1 2.32215
WASF1 WAS protein family, member 1 2.3205
ONECUT2 one cut homeobox 2 2.3176
AQP5 aquaporin 5 2.3111
COMP cartilage oligomeric matrix protein 2.3071
PRR7 proline rich 7 (synaptic) 2.30345
TMEM121 transmembrane protein 121 2.2935
HOXD1 homeobox D1 2.2848
NXN nucleoredoxin 2.2843
GCN1 GCN1 activator of EIF2AK4 2.25903
KLHL2 kelch-like family member 2 2.2434
MINPP1 multiple inositol-polyphosphate phosphatase 1 2.238
PRTN3 proteinase 3 2.2357
TOGARAM1 TOG array regulator of axonemal microtubules 1 2.2268
CAMKMT calmodulin-lysine N-methyltransferase 2.22145
CCNA1 cyclin A1 2.21755
CLASP2 cytoplasmic linker associated protein 2 2.19592
ANOS1 anosmin 1 2.193
PTPRZ1 protein tyrosine phosphatase, receptor-type, Z polypeptide 1 2.18855
DNAAF11 dynein axonemal assembly factor 11 2.1772
AGO2 argonaute RISC catalytic component 2 2.16625
DYNC2H1 dynein, cytoplasmic 2, heavy chain 1 2.1432
BNC1 basonuclin 1 2.1217
SLC22A3 solute carrier family 22 (organic cation transporter), member 3 2.1125
TLR2 toll-like receptor 2 2.1112
DHX57 DEAH (Asp-Glu-Ala-Asp/His) box polypeptide 57 2.1064
CYP7B1 cytochrome P450, family 7, subfamily B, polypeptide 1 2.09825
KCNJ12 potassium channel, inwardly rectifying subfamily J, member 12 2.09573
KCNS3 potassium voltage-gated channel, modifier subfamily S, member 3 2.0897
FXYD7 FXYD domain containing ion transport regulator 7 2.08025
RPGR retinitis pigmentosa GTPase regulator 2.0747
YTHDF1 YTH N(6)-methyladenosine RNA binding protein 1 2.0726
RXYLT1 ribitol xylosyltransferase 1 2.0671
P4HA1 prolyl 4-hydroxylase, alpha polypeptide I 2.06265
GNAT3 guanine nucleotide binding protein, alpha transducing 3 2.05835
SNRPF small nuclear ribonucleoprotein polypeptide F 2.0513
ANKRD6 ankyrin repeat domain 6 2.0416
ORM2 orosomucoid 2 2.03965
MLF1 myeloid leukemia factor 1 2.0343
GPR87 G protein-coupled receptor 87 2.03205
CPB2 carboxypeptidase B2 (plasma) 2.02605
TULP4 tubby like protein 4 2.01325
NOC4L nucleolar complex associated 4 homolog (S. cerevisiae) 2.00295

decreased expression

Symbol Name Standardized Value
LDHD lactate dehydrogenase D -4.799
KDM3A lysine (K)-specific demethylase 3A -4.67505
DERA deoxyribose-phosphate aldolase (putative) -4.66275
IARS2 isoleucyl-tRNA synthetase 2, mitochondrial -4.66275
TRAPPC3 trafficking protein particle complex 3 -4.55965
TCTA T-cell leukemia translocation altered -3.81125
ATP6V1D ATPase, H+ transporting, lysosomal 34kDa, V1 subunit D -3.4272
IMMT inner membrane protein, mitochondrial -3.09965
MIDEAS mitotic deacetylase associated SANT domain protein -2.82225
CD247 CD247 molecule -2.8205
RPP38 ribonuclease P/MRP 38kDa subunit -2.7537
OSBPL11 oxysterol binding protein-like 11 -2.7203
VTI1B vesicle transport through interaction with t-SNAREs 1B -2.65965
ANKMY2 ankyrin repeat and MYND domain containing 2 -2.6448
COQ9 coenzyme Q9 -2.5694
GRAP2 GRB2-related adaptor protein 2 -2.5108
TMEM186 transmembrane protein 186 -2.4584
TRAT1 T cell receptor associated transmembrane adaptor 1 -2.4574
RNF11 ring finger protein 11 -2.43085
ANPEP alanyl (membrane) aminopeptidase -2.3776
PCNT pericentrin -2.37555
ZDHHC7 zinc finger, DHHC-type containing 7 -2.3375
GATD3 glutamine amidotransferase class 1 domain containing 3 -2.33423
ANXA2 annexin A2 -2.28452
THAP11 THAP domain containing 11 -2.2806
SH2D1A SH2 domain containing 1A -2.26474
MLYCD malonyl-CoA decarboxylase -2.26375
PMS2 PMS2 postmeiotic segregation increased 2 (S. cerevisiae) -2.2333
HSD3B2 hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 2 -2.218
HIF1A hypoxia inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor) -2.2093
DLST dihydrolipoamide S-succinyltransferase (E2 component of 2-oxo-glutarate complex) -2.20295
PSMC2 proteasome (prosome, macropain) 26S subunit, ATPase, 2 -2.1919
CASP9 caspase 9, apoptosis-related cysteine peptidase -2.17355
ATP5PB ATP synthase peripheral stalk-membrane subunit b -2.1719
CEP63 centrosomal protein 63kDa -2.16905
GABARAPL2 GABA(A) receptor-associated protein-like 2 -2.1581
GZMB granzyme B (granzyme 2, cytotoxic T-lymphocyte-associated serine esterase 1) -2.1407
ACADS acyl-CoA dehydrogenase, C-2 to C-3 short chain -2.13395
AFG3L2 AFG3-like AAA ATPase 2 -2.12375
TSEN34 TSEN34 tRNA splicing endonuclease subunit -2.1235
ATP5PF ATP synthase peripheral stalk subunit F6 -2.1073
SNW1 SNW domain containing 1 -2.10555
PHYH phytanoyl-CoA 2-hydroxylase -2.10275
CD96 CD96 molecule -2.10155
EIF2B2 eukaryotic translation initiation factor 2B, subunit 2 beta, 39kDa -2.08725
ITGAL integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen 1; alpha polypeptide) -2.05855
ELF2 E74-like factor 2 (ets domain transcription factor) -2.0478
TNFRSF1B tumor necrosis factor receptor superfamily, member 1B -2.04655
PTCD1 pentatricopeptide repeat domain 1 -2.0373
NOP53 NOP53 ribosome biogenesis factor -2.03185
ZNF185 zinc finger protein 185 (LIM domain) -2.02985
ARID4A AT rich interactive domain 4A (RBP1-like) -2.01505
CARHSP1 calcium regulated heat stable protein 1, 24kDa -2.01295
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.00295
GNG12 guanine nucleotide binding protein (G protein), gamma 12 -2.0028