CRCGN017_MCF10A.TP53.M_24H:E23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sodium (e)-4-hydroxy-3-((4-sulfonatonaphthalen-1-yl)diazenyl)naphthalene-1-sulfonate 35.06 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

27 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:E23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
BZW2 basic leucine zipper and W2 domains 2 4.03512
POLE2 polymerase (DNA directed), epsilon 2, accessory subunit 2.97942
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.57902
MNAT1 MNAT CDK-activating kinase assembly factor 1 2.52525
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 2.46696
DENND2D DENN/MADD domain containing 2D 2.26458
PDLIM1 PDZ and LIM domain 1 2.04797
FBXO11 F-box protein 11 2.04519

decreased expression

Symbol Name Standardized Value
NSDHL NAD(P) dependent steroid dehydrogenase-like -4.78426
OXA1L oxidase (cytochrome c) assembly 1-like -4.46554
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.70937
FAM50A family with sequence similarity 50, member A -2.84365
IDH3G isocitrate dehydrogenase 3 (NAD+) gamma -2.6148
CETN2 centrin, EF-hand protein, 2 -2.39525
APOBEC3F apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3F -2.26362
KRT14 keratin 14, type I -2.18764
GDF15 growth differentiation factor 15 -2.18734
NAA10 N(alpha)-acetyltransferase 10, NatA catalytic subunit -2.17367
PIK3C2B phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 beta -2.16311
SSR4 signal sequence receptor, delta -2.12851
TKT transketolase -2.10916
FAM3A family with sequence similarity 3, member A -2.09233
GMPR2 guanosine monophosphate reductase 2 -2.0683
TUBA4B tubulin, alpha 4b -2.06144
BRCC3 BRCA1/BRCA2-containing complex, subunit 3 -2.05088
LDOC1 leucine zipper, down-regulated in cancer 1 -2.04612
ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1 -2.03006