CRCGN017_MCF10A.TP53.M_24H:F02 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description beta-carotene 17.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F02 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 5.0
HDGFL3 HDGF like 3 4.15821
RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2) 4.05075
ACAA1 acetyl-CoA acyltransferase 1 3.4888
NOL3 nucleolar protein 3 (apoptosis repressor with CARD domain) 3.1512
SNCA synuclein, alpha (non A4 component of amyloid precursor) 3.02625
PRR7 proline rich 7 (synaptic) 2.89225
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.86575
PACSIN3 protein kinase C and casein kinase substrate in neurons 3 2.8433
NUCB2 nucleobindin 2 2.32545
ALX1 ALX homeobox 1 2.28655
BCKDK branched chain ketoacid dehydrogenase kinase 2.25715
ARFGAP2 ADP-ribosylation factor GTPase activating protein 2 2.12595
LYN LYN proto-oncogene, Src family tyrosine kinase 2.09802
BZW2 basic leucine zipper and W2 domains 2 2.0789
SLC5A6 solute carrier family 5 (sodium/multivitamin and iodide cotransporter), member 6 2.03685
CTBP2 C-terminal binding protein 2 2.0339
ZNF26 zinc finger protein 26 2.0008

decreased expression

Symbol Name Standardized Value
CAB39 calcium binding protein 39 -5.60425
PCNA proliferating cell nuclear antigen -5.5173
HSPA8 heat shock 70kDa protein 8 -5.18538
KRT14 keratin 14, type I -5.0
ADI1 acireductone dioxygenase 1 -4.7754
DYNLT3 dynein, light chain, Tctex-type 3 -4.43845
RBM34 RNA binding motif protein 34 -3.45445
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.84465
PSMG1 proteasome (prosome, macropain) assembly chaperone 1 -2.72095
EIF3H eukaryotic translation initiation factor 3, subunit H -2.5796
AATF apoptosis antagonizing transcription factor -2.49815
TNFRSF21 tumor necrosis factor receptor superfamily, member 21 -2.37855
CDS2 CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 -2.3443
XPO7 exportin 7 -2.22333
ATIC 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase -2.20825
BMP2 bone morphogenetic protein 2 -2.20692
CIAPIN1 cytokine induced apoptosis inhibitor 1 -2.1935
STXBP1 syntaxin binding protein 1 -2.18675
MKKS McKusick-Kaufman syndrome -2.0447
KIZ kizuna centrosomal protein -2.00915
ZNF165 zinc finger protein 165 -2.00365