CRCGN017_MCF10A.TP53.M_24H:F10 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 102.48 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

74 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F10 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.38968
KLHL21 kelch-like family member 21 4.24353
RELB v-rel avian reticuloendotheliosis viral oncogene homolog B 4.15923
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.74951
KCTD5 potassium channel tetramerization domain containing 5 3.39597
SPAG7 sperm associated antigen 7 2.90429
ABHD6 abhydrolase domain containing 6 2.83439
OLFML2B olfactomedin-like 2B 2.66851
AMDHD2 amidohydrolase domain containing 2 2.62883
HBB hemoglobin, beta 2.58503
SKIC2 SKI2 subunit of superkiller complex 2.57975
HBA1 hemoglobin, alpha 1 2.55134
MCM5 minichromosome maintenance complex component 5 2.50355
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.42788
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.38717
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.34737
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.30454
MINDY1 MINDY lysine 48 deubiquitinase 1 2.19614
SELENOW selenoprotein W 2.11894
COMP cartilage oligomeric matrix protein 2.11683
INPP1 inositol polyphosphate-1-phosphatase 2.0915
DBNDD2 dysbindin (dystrobrevin binding protein 1) domain containing 2 2.07651
PPIC peptidylprolyl isomerase C (cyclophilin C) 2.07132
KRT13 keratin 13, type I 2.06549
MYOD1 myogenic differentiation 1 2.01134
COX7A1 cytochrome c oxidase subunit VIIa polypeptide 1 (muscle) 2.01004
LINC02762 long intergenic non-protein coding RNA 2762 2.00631

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -5.39647
UBE2C ubiquitin-conjugating enzyme E2C -5.0375
PSRC1 proline/serine-rich coiled-coil 1 -4.73939
PLK1 polo-like kinase 1 -4.03815
TOP2A topoisomerase (DNA) II alpha 170kDa -3.4488
DHRS7 dehydrogenase/reductase (SDR family) member 7 -3.42546
KIF20A kinesin family member 20A -3.34972
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.31595
CDC20 cell division cycle 20 -3.22131
CCNB1 cyclin B1 -3.16828
AURKA aurora kinase A -2.88694
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.86927
TXNRD1 thioredoxin reductase 1 -2.82119
HSPA1A heat shock 70kDa protein 1A -2.79321
CENPA centromere protein A -2.70743
GDF15 growth differentiation factor 15 -2.63678
KIF4A kinesin family member 4A -2.52917
HJURP Holliday junction recognition protein -2.5012
CDCA8 cell division cycle associated 8 -2.49989
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.48017
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.38501
CDCA3 cell division cycle associated 3 -2.33634
NEK2 NIMA-related kinase 2 -2.28731
PLEKHA8 pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 8 -2.26532
PMCH pro-melanin-concentrating hormone -2.20902
KIF18B kinesin family member 18B -2.19273
NDC80 NDC80 kinetochore complex component -2.18391
KIF11 kinesin family member 11 -2.17442
MKI67 marker of proliferation Ki-67 -2.15698
NCAPD2 non-SMC condensin I complex, subunit D2 -2.15209
RIMBP2 RIMS binding protein 2 -2.15187
LBR lamin B receptor -2.12904
NLK nemo-like kinase -2.10565
CCDC86 coiled-coil domain containing 86 -2.10262
COG7 component of oligomeric golgi complex 7 -2.09367
CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3 -2.06959
UTRN utrophin -2.0573
PTH1R parathyroid hormone 1 receptor -2.05667
SPC25 SPC25, NDC80 kinetochore complex component -2.04793
ERN1 endoplasmic reticulum to nucleus signaling 1 -2.04331
EXOC2 exocyst complex component 2 -2.03629
TROAP trophinin associated protein -2.03494
INCENP inner centromere protein antigens 135/155kDa -2.02374
KDM3A lysine (K)-specific demethylase 3A -2.01874
UBE2O ubiquitin-conjugating enzyme E2O -2.00578
TPX2 TPX2, microtubule-associated -2.00198
CCNF cyclin F -2.00106