CRCGN017_MCF10A.TP53.M_24H:F11 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 34.16 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

174 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F11 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
ADO 2-aminoethanethiol (cysteamine) dioxygenase 6.43686
AGR2 anterior gradient 2 4.80597
AMDHD2 amidohydrolase domain containing 2 4.70621
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 4.57188
ST3GAL5 ST3 beta-galactoside alpha-2,3-sialyltransferase 5 4.31727
SPAG4 sperm associated antigen 4 3.77706
NRBF2 nuclear receptor binding factor 2 3.39122
CNRIP1 cannabinoid receptor interacting protein 1 3.29715
HBA1 hemoglobin, alpha 1 3.09652
LGMN legumain 3.04229
WFS1 Wolfram syndrome 1 (wolframin) 2.90158
GSTT1 glutathione S-transferase theta 1 2.82233
FZD7 frizzled class receptor 7 2.79596
KRT13 keratin 13, type I 2.74177
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.68973
VSTM4 V-set and transmembrane domain containing 4 2.68295
HMGXB4 HMG box domain containing 4 2.60693
FGFR4 fibroblast growth factor receptor 4 2.60431
SEL1L3 sel-1 suppressor of lin-12-like 3 (C. elegans) 2.54693
TSPAN8 tetraspanin 8 2.52865
KRT33A keratin 33A, type I 2.51906
KCNA3 potassium channel, voltage gated shaker related subfamily A, member 3 2.49651
BACE2 beta-site APP-cleaving enzyme 2 2.49416
GSPT2 G1 to S phase transition 2 2.48578
TICAM1 toll-like receptor adaptor molecule 1 2.47526
LY6D lymphocyte antigen 6 complex, locus D 2.45419
MINDY1 MINDY lysine 48 deubiquitinase 1 2.4517
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.43046
NCK1 NCK adaptor protein 1 2.42563
ACTC1 actin, alpha, cardiac muscle 1 2.41898
TMEM109 transmembrane protein 109 2.41746
MX1 MX dynamin-like GTPase 1 2.40151
PADI3 peptidyl arginine deiminase, type III 2.39967
PRR15L proline rich 15-like 2.38916
ARMCX6 armadillo repeat containing, X-linked 6 2.38772
DNMT1 DNA (cytosine-5-)-methyltransferase 1 2.38157
MCM5 minichromosome maintenance complex component 5 2.37272
MIDEAS mitotic deacetylase associated SANT domain protein 2.34291
CENPU centromere protein U 2.3393
LY96 lymphocyte antigen 96 2.33269
EPHX3 epoxide hydrolase 3 2.32791
ACOX3 acyl-CoA oxidase 3, pristanoyl 2.30938
LAX1 lymphocyte transmembrane adaptor 1 2.30372
DKK2 dickkopf WNT signaling pathway inhibitor 2 2.29874
SPRR2B small proline-rich protein 2B 2.29477
PHF7 PHD finger protein 7 2.29061
CCL17 chemokine (C-C motif) ligand 17 2.27875
TMEM40 transmembrane protein 40 2.26922
PDZK1IP1 PDZK1 interacting protein 1 2.2494
RPH3AL rabphilin 3A-like (without C2 domains) 2.24756
IL1RN interleukin 1 receptor antagonist 2.24689
NDN necdin, melanoma antigen (MAGE) family member 2.24048
NUP43 nucleoporin 43kDa 2.21974
NGRN neugrin, neurite outgrowth associated 2.21268
NFKBIA nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha 2.20377
COQ4 coenzyme Q4 2.19578
TMEM268 transmembrane protein 268 2.18788
REG1A regenerating islet-derived 1 alpha 2.18766
IGFBP4 insulin-like growth factor binding protein 4 2.18081
EIF4EBP1 eukaryotic translation initiation factor 4E binding protein 1 2.17905
HHAT hedgehog acyltransferase 2.17637
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.16758
C2CD2 C2 calcium-dependent domain containing 2 2.16425
TTLL3 tubulin tyrosine ligase-like family member 3 2.15235
GPC3 glypican 3 2.15184
CLCA2 chloride channel accessory 2 2.14651
RAB27A RAB27A, member RAS oncogene family 2.14464
PARM1 prostate androgen-regulated mucin-like protein 1 2.13732
ADAMTS1 ADAM metallopeptidase with thrombospondin type 1 motif, 1 2.13278
BCR breakpoint cluster region 2.13272
HS3ST1 heparan sulfate (glucosamine) 3-O-sulfotransferase 1 2.12993
SPRR1A small proline-rich protein 1A 2.12586
FABP4 fatty acid binding protein 4, adipocyte 2.1219
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 2.11332
POMK protein-O-mannose kinase 2.10892
FOSB FBJ murine osteosarcoma viral oncogene homolog B 2.1071
PLBD1 phospholipase B domain containing 1 2.10283
HBB hemoglobin, beta 2.09977
LIPG lipase, endothelial 2.09955
CH25H cholesterol 25-hydroxylase 2.08896
ETNK1 ethanolamine kinase 1 2.08426
DDTL D-dopachrome tautomerase-like 2.06725
CPVL carboxypeptidase, vitellogenic-like 2.05672
BHLHE41 basic helix-loop-helix family, member e41 2.0529
FUT3 fucosyltransferase 3 (galactoside 3(4)-L-fucosyltransferase, Lewis blood group) 2.04113
DUSP5 dual specificity phosphatase 5 2.04094
PPCDC phosphopantothenoylcysteine decarboxylase 2.0387
ZAP70 zeta-chain (TCR) associated protein kinase 70kDa 2.03386
BTG2 BTG family, member 2 2.03137
DCHS2 dachsous cadherin-related 2 2.03134
ERLIN2 ER lipid raft associated 2 2.02592
INPP1 inositol polyphosphate-1-phosphatase 2.01893
ADRB3 adrenoceptor beta 3 2.01725
CCL22 chemokine (C-C motif) ligand 22 2.0161
PKP1 plakophilin 1 2.01334
AGA aspartylglucosaminidase 2.01278

decreased expression

Symbol Name Standardized Value
PSRC1 proline/serine-rich coiled-coil 1 -6.19913
CCNB1 cyclin B1 -5.79751
UBE2C ubiquitin-conjugating enzyme E2C -5.49286
PLK1 polo-like kinase 1 -4.97198
CDC20 cell division cycle 20 -4.65844
KIF20A kinesin family member 20A -4.49398
TLK2 tousled-like kinase 2 -4.36186
COG2 component of oligomeric golgi complex 2 -4.1897
TOP2A topoisomerase (DNA) II alpha 170kDa -4.16722
AURKA aurora kinase A -4.04985
KIF4A kinesin family member 4A -3.68448
CAB39 calcium binding protein 39 -3.38225
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.19997
CENPA centromere protein A -3.09598
HSPA8 heat shock 70kDa protein 8 -3.08567
HSPA1A heat shock 70kDa protein 1A -3.0342
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.97459
CD58 CD58 molecule -2.95726
LBR lamin B receptor -2.86345
CDCA3 cell division cycle associated 3 -2.85026
URGCP upregulator of cell proliferation -2.83488
KIF15 kinesin family member 15 -2.82567
KIF11 kinesin family member 11 -2.78094
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.75916
CDC25C cell division cycle 25C -2.6826
KIF14 kinesin family member 14 -2.6551
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.6495
MAT2A methionine adenosyltransferase II, alpha -2.5604
HTRA1 HtrA serine peptidase 1 -2.55377
CDKN3 cyclin-dependent kinase inhibitor 3 -2.54758
VDAC1 voltage-dependent anion channel 1 -2.53977
PSMA5 proteasome (prosome, macropain) subunit, alpha type, 5 -2.51626
GPSM2 G-protein signaling modulator 2 -2.50756
OXA1L oxidase (cytochrome c) assembly 1-like -2.50096
RNF123 ring finger protein 123 -2.4877
JMJD6 jumonji domain containing 6 -2.48
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.45898
TPX2 TPX2, microtubule-associated -2.40893
FOXD1 forkhead box D1 -2.40797
HMGCR 3-hydroxy-3-methylglutaryl-CoA reductase -2.40662
NR1D2 nuclear receptor subfamily 1, group D, member 2 -2.36532
ATF5 activating transcription factor 5 -2.36494
GRWD1 glutamate-rich WD repeat containing 1 -2.35088
TRAK2 trafficking protein, kinesin binding 2 -2.33198
AURKB aurora kinase B -2.32541
DEPDC1 DEP domain containing 1 -2.26834
HJURP Holliday junction recognition protein -2.25645
NVL nuclear VCP-like -2.25357
TKT transketolase -2.25011
PLGLB2 plasminogen-like B2 -2.21558
ERBIN erbb2 interacting protein -2.21369
CCNB2 cyclin B2 -2.18482
BIRC5 baculoviral IAP repeat containing 5 -2.15272
COA7 cytochrome c oxidase assembly factor 7 (putative) -2.15161
RBM12B RNA binding motif protein 12B -2.15032
EIF3H eukaryotic translation initiation factor 3, subunit H -2.14594
RPAP2 RNA polymerase II associated protein 2 -2.14135
TMEM115 transmembrane protein 115 -2.12609
AIMP2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 -2.12516
PPM1D protein phosphatase, Mg2+/Mn2+ dependent, 1D -2.11651
PIMREG PICALM interacting mitotic regulator -2.10502
EXPH5 exophilin 5 -2.09656
NUSAP1 nucleolar and spindle associated protein 1 -2.0961
AGAP1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 -2.08934
TROAP trophinin associated protein -2.08716
RPP38 ribonuclease P/MRP 38kDa subunit -2.08553
DNAJA1 DnaJ (Hsp40) homolog, subfamily A, member 1 -2.07459
NEK2 NIMA-related kinase 2 -2.07186
FNBP1L formin binding protein 1-like -2.06657
XPO6 exportin 6 -2.06554
CELSR3 cadherin, EGF LAG seven-pass G-type receptor 3 -2.03678
RELA v-rel avian reticuloendotheliosis viral oncogene homolog A -2.03562
PDHB pyruvate dehydrogenase (lipoamide) beta -2.02519
SLC16A1 solute carrier family 16 (monocarboxylate transporter), member 1 -2.0087
SF3B4 splicing factor 3b, subunit 4, 49kDa -2.00691
DHX8 DEAH (Asp-Glu-Ala-His) box polypeptide 8 -2.00546
PCF11 PCF11 cleavage and polyadenylation factor subunit -2.00353
METTL2A methyltransferase like 2A -2.00232