CRCGN017_MCF10A.TP53.M_24H:F12 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description pyrimethamine 11.39 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

54 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F12 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 5.45479
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.30462
MAMLD1 mastermind-like domain containing 1 4.28081
COMP cartilage oligomeric matrix protein 4.10032
CNRIP1 cannabinoid receptor interacting protein 1 3.962
SPAG7 sperm associated antigen 7 3.02023
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.84928
MINDY1 MINDY lysine 48 deubiquitinase 1 2.69522
RBP4 retinol binding protein 4, plasma 2.62818
ALDOC aldolase C, fructose-bisphosphate 2.53207
TRIM6-TRIM34 TRIM6-TRIM34 readthrough 2.37328
DENND2D DENN/MADD domain containing 2D 2.35451
QTMAN queuosine-tRNA mannosyltransferase 2.34043
GARRE1 granule associated Rac and RHOG effector 1 2.30981
TRIM38 tripartite motif containing 38 2.30133
DHRS1 dehydrogenase/reductase (SDR family) member 1 2.28531
AGR2 anterior gradient 2 2.19257
DDX10 DEAD (Asp-Glu-Ala-Asp) box polypeptide 10 2.10068
GGT5 gamma-glutamyltransferase 5 2.09623
PGAP2 post-GPI attachment to proteins 2 2.09202
IFT52 intraflagellar transport 52 2.07747
CCN3 cellular communication network factor 3 2.06945
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 2.03609
HSPB2 heat shock 27kDa protein 2 2.03591
RNF113A ring finger protein 113A 2.02133
HPS5 Hermansky-Pudlak syndrome 5 2.00415

decreased expression

Symbol Name Standardized Value
ADI1 acireductone dioxygenase 1 -4.12894
DERA deoxyribose-phosphate aldolase (putative) -3.95866
DSG2 desmoglein 2 -3.3252
TM9SF3 transmembrane 9 superfamily member 3 -3.29649
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.89775
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -2.83419
HOXA5 homeobox A5 -2.8149
HSPA1A heat shock 70kDa protein 1A -2.66162
MAGI1 membrane associated guanylate kinase, WW and PDZ domain containing 1 -2.65804
CANT1 calcium activated nucleotidase 1 -2.4914
AURKA aurora kinase A -2.48032
PPRC1 peroxisome proliferator-activated receptor gamma, coactivator-related 1 -2.38707
FBXO21 F-box protein 21 -2.38236
TMEM115 transmembrane protein 115 -2.36988
AGPAT5 1-acylglycerol-3-phosphate O-acyltransferase 5 -2.29678
NOP16 NOP16 nucleolar protein -2.21552
ETS1 v-ets avian erythroblastosis virus E26 oncogene homolog 1 -2.18112
SDC1 syndecan 1 -2.17241
EMC3 ER membrane protein complex subunit 3 -2.17126
TRIB1 tribbles pseudokinase 1 -2.15147
SORBS3 sorbin and SH3 domain containing 3 -2.10598
SOCS2 suppressor of cytokine signaling 2 -2.10241
FJX1 four jointed box 1 (Drosophila) -2.09078
TUSC2 tumor suppressor candidate 2 -2.0657
COL17A1 collagen, type XVII, alpha 1 -2.06312
IRF1 interferon regulatory factor 1 -2.06079
EXT1 exostosin glycosyltransferase 1 -2.04453
TENT4A terminal nucleotidyltransferase 4A -2.03646