CRCGN017_MCF10A.TP53.M_24H:F13 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description l-ascorbic acid 100.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F13 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
AGR2 anterior gradient 2 7.29366
KCTD5 potassium channel tetramerization domain containing 5 3.87274
SNAP25 synaptosomal-associated protein, 25kDa 2.848
PHKA1 phosphorylase kinase, alpha 1 (muscle) 2.7632
KLHL9 kelch-like family member 9 2.32401
TSEN2 TSEN2 tRNA splicing endonuclease subunit 2.31715
EVL Enah/Vasp-like 2.26697
ABL1 ABL proto-oncogene 1, non-receptor tyrosine kinase 2.193
CCNF cyclin F 2.1448
OLFML2B olfactomedin-like 2B 2.11023
VGLL4 vestigial-like family member 4 2.08152
COMP cartilage oligomeric matrix protein 2.05623
FOS FBJ murine osteosarcoma viral oncogene homolog 2.04264
GPATCH8 G patch domain containing 8 2.01157

decreased expression

Symbol Name Standardized Value
PRPF4 pre-mRNA processing factor 4 -4.12101
TXNDC9 thioredoxin domain containing 9 -3.68353
KIF14 kinesin family member 14 -3.54804
ITFG1 integrin alpha FG-GAP repeat containing 1 -3.54722
KDM3A lysine (K)-specific demethylase 3A -2.97837
VDAC1 voltage-dependent anion channel 1 -2.87108
NPDC1 neural proliferation, differentiation and control, 1 -2.86009
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.7713
OXA1L oxidase (cytochrome c) assembly 1-like -2.72427
PUF60 poly-U binding splicing factor 60KDa -2.70533
PSIP1 PC4 and SFRS1 interacting protein 1 -2.54436
SDC1 syndecan 1 -2.47076
SOX17 SRY (sex determining region Y)-box 17 -2.33173
BASP1 brain abundant, membrane attached signal protein 1 -2.24735
TMEM131 transmembrane protein 131 -2.19551
GRWD1 glutamate-rich WD repeat containing 1 -2.19254
CHST10 carbohydrate sulfotransferase 10 -2.17889
SEMA4C sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4C -2.15201
HAUS6 HAUS augmin-like complex, subunit 6 -2.14849
CNNM4 cyclin and CBS domain divalent metal cation transport mediator 4 -2.14634
RNF2 ring finger protein 2 -2.09441
STARD7 StAR-related lipid transfer (START) domain containing 7 -2.06996
LITAF lipopolysaccharide-induced TNF factor -2.06531
TENT4A terminal nucleotidyltransferase 4A -2.0471
TIMP1 TIMP metallopeptidase inhibitor 1 -2.02922