CRCGN017_MCF10A.TP53.M_24H:F16 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,2-dibromoethane 98.95 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

76 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 3.33109
SSBP2 single-stranded DNA binding protein 2 3.16325
ACAA1 acetyl-CoA acyltransferase 1 2.5087
HMGA2 high mobility group AT-hook 2 2.40516
TLCD3A TLC domain containing 3A 2.40481
SPRY2 sprouty homolog 2 (Drosophila) 2.26219
FOXD1 forkhead box D1 2.19363
MOK MOK protein kinase 2.1562
GCSH glycine cleavage system protein H (aminomethyl carrier) 2.13684
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.12193
TGFBR2 transforming growth factor, beta receptor II (70/80kDa) 2.10511
SPCS1 signal peptidase complex subunit 1 homolog (S. cerevisiae) 2.08766
UBQLN2 ubiquilin 2 2.07746
FZD6 frizzled class receptor 6 2.01937

decreased expression

Symbol Name Standardized Value
ISOC1 isochorismatase domain containing 1 -4.11581
CCNB1 cyclin B1 -4.00629
DNM1L dynamin 1-like -3.97037
COG7 component of oligomeric golgi complex 7 -3.95047
WASHC4 WASH complex subunit 4 -3.89953
KRT14 keratin 14, type I -3.73093
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -3.67795
MAPK13 mitogen-activated protein kinase 13 -3.62309
TRIB3 tribbles pseudokinase 3 -3.39083
ZNF652 zinc finger protein 652 -2.85412
PPP4C protein phosphatase 4, catalytic subunit -2.71893
NPIPA6 nuclear pore complex interacting protein family, member A6 -2.64684
PYCARD PYD and CARD domain containing -2.61073
GTF2H3 general transcription factor IIH, polypeptide 3, 34kDa -2.55879
PEG3 paternally expressed 3 -2.53909
TRMT2B tRNA methyltransferase 2 homolog B (S. cerevisiae) -2.51411
C15ORF38-AP3S2 C15orf38-AP3S2 readthrough -2.50334
CALY calcyon neuron-specific vesicular protein -2.50171
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -2.49001
TENT4A terminal nucleotidyltransferase 4A -2.44694
DSG2 desmoglein 2 -2.43146
FLCN folliculin -2.42647
GDF15 growth differentiation factor 15 -2.36246
TEAD3 TEA domain family member 3 -2.31332
EVX1 even-skipped homeobox 1 -2.31081
ZNF669 zinc finger protein 669 -2.3083
ITGAM integrin, alpha M (complement component 3 receptor 3 subunit) -2.26331
LMBR1L limb development membrane protein 1-like -2.26022
THBS2 thrombospondin 2 -2.24706
GOLT1A golgi transport 1A -2.22911
GATC glutamyl-tRNA(Gln) amidotransferase, subunit C -2.22508
DOK2 docking protein 2, 56kDa -2.21468
SYNPO2 synaptopodin 2 -2.20956
IL17B interleukin 17B -2.2041
ACAN aggrecan -2.19303
SPATS2 spermatogenesis associated, serine-rich 2 -2.17031
MRPS10 mitochondrial ribosomal protein S10 -2.16069
ADAMTSL4 ADAMTS-like 4 -2.15027
XPNPEP3 X-prolyl aminopeptidase 3, mitochondrial -2.14569
EFS embryonal Fyn-associated substrate -2.14539
VEZT vezatin, adherens junctions transmembrane protein -2.14265
ZNF91 zinc finger protein 91 -2.1285
IFNB1 interferon, beta 1, fibroblast -2.10874
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.10709
SCN2B sodium channel, voltage gated, type II beta subunit -2.1058
MATN4 matrilin 4 -2.10487
ZNF74 zinc finger protein 74 -2.09264
PCDHGA8 protocadherin gamma subfamily A, 8 -2.08341
BID BH3 interacting domain death agonist -2.07376
RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated) -2.06745
ZNF611 zinc finger protein 611 -2.0624
ATP1A3 ATPase, Na+/K+ transporting, alpha 3 polypeptide -2.05903
FIG4 FIG4 phosphoinositide 5-phosphatase -2.04844
ETV3 ets variant 3 -2.03964
UBFD1 ubiquitin family domain containing 1 -2.03217
IL10RA interleukin 10 receptor, alpha -2.02098
CAMKV CaM kinase-like vesicle-associated -2.01946
TBK1 TANK-binding kinase 1 -2.01845
TMT1A thiol methyltransferase 1A -2.01683
USP15 ubiquitin specific peptidase 15 -2.011
CNTN1 contactin 1 -2.00816
TEP1 telomerase-associated protein 1 -2.00555