CRCGN017_MCF10A.TP53.M_24H:F20 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-diethyl o-(4-nitrophenyl) thiophosphate 33.99 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

26 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F20 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CXCL2 chemokine (C-X-C motif) ligand 2 5.07804
STK10 serine/threonine kinase 10 4.88076
CXCR4 chemokine (C-X-C motif) receptor 4 4.8138
WFS1 Wolfram syndrome 1 (wolframin) 4.66505
CCP110 centriolar coiled coil protein 110kDa 4.55623
CCL2 chemokine (C-C motif) ligand 2 4.36976
GNAI1 guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 1 4.36435
LGMN legumain 3.34807
VGLL4 vestigial-like family member 4 3.11362
RNF111 ring finger protein 111 2.5432
MCUR1 mitochondrial calcium uniporter regulator 1 2.53121
NUP205 nucleoporin 205kDa 2.5275
RBP4 retinol binding protein 4, plasma 2.35825
CYREN cell cycle regulator of NHEJ 2.07505
LTF lactotransferrin 2.03631

decreased expression

Symbol Name Standardized Value
ENOPH1 enolase-phosphatase 1 -4.87085
BASP1 brain abundant, membrane attached signal protein 1 -4.43378
BAG3 BCL2-associated athanogene 3 -4.32606
SLC7A5 solute carrier family 7 (amino acid transporter light chain, L system), member 5 -3.87834
GDF15 growth differentiation factor 15 -3.38973
TP53 tumor protein p53 -3.31848
GRN granulin -2.86906
TENT4A terminal nucleotidyltransferase 4A -2.66157
PRUNE2 prune homolog 2 (Drosophila) -2.37083
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.1662
CDK18 cyclin-dependent kinase 18 -2.11379