CRCGN017_MCF10A.TP53.M_24H:F21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description o,o-diethyl o-(4-nitrophenyl) thiophosphate 11.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

53 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PPP1R13B protein phosphatase 1, regulatory subunit 13B 5.12825
IDE insulin-degrading enzyme 4.93172
UGDH UDP-glucose 6-dehydrogenase 4.78075
AGR2 anterior gradient 2 4.66175
SPAG4 sperm associated antigen 4 4.3214
PRKCH protein kinase C, eta 3.79973
IGHMBP2 immunoglobulin mu binding protein 2 2.6476
PECR peroxisomal trans-2-enoyl-CoA reductase 2.4421
LORICRIN loricrin cornified envelope precursor protein 2.44175
GIMAP6 GTPase, IMAP family member 6 2.42695
SPINK5 serine peptidase inhibitor, Kazal type 5 2.39315
TBC1D31 TBC1 domain family, member 31 2.36695
HSD17B8 hydroxysteroid (17-beta) dehydrogenase 8 2.27845
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.21585
SOSTDC1 sclerostin domain containing 1 2.0985
NAA60 N(alpha)-acetyltransferase 60, NatF catalytic subunit 2.06983
LCE2B late cornified envelope 2B 2.0671

decreased expression

Symbol Name Standardized Value
NUP85 nucleoporin 85kDa -4.67235
GADD45B growth arrest and DNA-damage-inducible, beta -4.67
ADI1 acireductone dioxygenase 1 -4.66275
PRPF4 pre-mRNA processing factor 4 -4.56187
CD58 CD58 molecule -3.88205
MRPL58 mitochondrial ribosomal protein L58 -3.6007
G3BP1 GTPase activating protein (SH3 domain) binding protein 1 -3.3149
RNF167 ring finger protein 167 -3.2345
MRPS7 mitochondrial ribosomal protein S7 -3.0712
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.91175
CCNDBP1 cyclin D-type binding-protein 1 -2.79325
SUMO4 small ubiquitin-like modifier 4 -2.73495
ACOX1 acyl-CoA oxidase 1, palmitoyl -2.67105
KCNK1 potassium channel, two pore domain subfamily K, member 1 -2.59133
NAT9 N-acetyltransferase 9 (GCN5-related, putative) -2.57905
FBXO21 F-box protein 21 -2.57417
ANXA2 annexin A2 -2.51338
LLGL2 lethal giant larvae homolog 2 (Drosophila) -2.5055
SLC31A1 solute carrier family 31 (copper transporter), member 1 -2.40715
MTFR1 mitochondrial fission regulator 1 -2.39945
TIMP1 TIMP metallopeptidase inhibitor 1 -2.3808
GRB2 growth factor receptor-bound protein 2 -2.34505
POLE3 polymerase (DNA directed), epsilon 3, accessory subunit -2.2951
HDHD3 haloacid dehalogenase-like hydrolase domain containing 3 -2.27385
SAP30BP SAP30 binding protein -2.27105
KCTD2 potassium channel tetramerization domain containing 2 -2.21858
PSMD5 proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 -2.1905
BSPRY B-box and SPRY domain containing -2.1707
RGS2 regulator of G-protein signaling 2 -2.15225
ANKRD10 ankyrin repeat domain 10 -2.15165
BDNF brain-derived neurotrophic factor -2.14295
GSTT1 glutathione S-transferase theta 1 -2.13625
ALAD aminolevulinate dehydratase -2.13517
SLC16A3 solute carrier family 16 (monocarboxylate transporter), member 3 -2.10847
ILK integrin-linked kinase -2.09345
JPT1 Jupiter microtubule associated homolog 1 -2.0391