CRCGN017_MCF10A.TP53.M_24H:F22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methotrexate 99.37 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

125 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HBA1 hemoglobin, alpha 1 5.58034
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 5.54706
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 5.35522
ABCF1 ATP-binding cassette, sub-family F (GCN20), member 1 4.0942
SPAG4 sperm associated antigen 4 3.08701
BDH1 3-hydroxybutyrate dehydrogenase, type 1 3.03361
ANO10 anoctamin 10 3.0335
TICAM1 toll-like receptor adaptor molecule 1 2.98814
PLSCR1 phospholipid scramblase 1 2.98185
AMDHD2 amidohydrolase domain containing 2 2.92959
HBB hemoglobin, beta 2.91398
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.81806
MUC1 mucin 1, cell surface associated 2.79019
PRSS23 protease, serine, 23 2.78144
CAPN1 calpain 1, (mu/I) large subunit 2.76103
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.73354
HCAR3 hydroxycarboxylic acid receptor 3 2.70497
IKBKE inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon 2.68676
EPHA1 EPH receptor A1 2.66868
DEPDC5 DEP domain containing 5 2.66038
IL1B interleukin 1, beta 2.60674
MEA1 male-enhanced antigen 1 2.56103
MINDY1 MINDY lysine 48 deubiquitinase 1 2.49301
ADGRE5 adhesion G protein-coupled receptor E5 2.49017
TCEA2 transcription elongation factor A (SII), 2 2.35776
ABHD11 abhydrolase domain containing 11 2.35406
ZMIZ1 zinc finger, MIZ-type containing 1 2.32923
CDC45 cell division cycle 45 2.31437
CYB5R1 cytochrome b5 reductase 1 2.28925
SFI1 Sfi1 homolog, spindle assembly associated (yeast) 2.25577
FKBP14 FK506 binding protein 14, 22 kDa 2.25415
MCM5 minichromosome maintenance complex component 5 2.24419
PVALB parvalbumin 2.22921
CIRBP cold inducible RNA binding protein 2.22786
PSMF1 proteasome (prosome, macropain) inhibitor subunit 1 (PI31) 2.17717
TEX2 testis expressed 2 2.17181
MGAM maltase-glucoamylase 2.15378
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.15012
TINF2 TERF1 (TRF1)-interacting nuclear factor 2 2.11866
ACAA1 acetyl-CoA acyltransferase 1 2.1006
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.08912
IFIT1 interferon-induced protein with tetratricopeptide repeats 1 2.0794
METTL17 methyltransferase like 17 2.07341
DDTL D-dopachrome tautomerase-like 2.06503
B3GNT4 UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 4 2.06481
INAVA innate immunity activator 2.04882
DHRS4 dehydrogenase/reductase (SDR family) member 4 2.04235
NDUFV1 NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa 2.01679
SOX15 SRY (sex determining region Y)-box 15 2.01497
KL klotho 2.0097
DDRGK1 DDRGK domain containing 1 2.00484

decreased expression

Symbol Name Standardized Value
UBE2C ubiquitin-conjugating enzyme E2C -6.94647
NPDC1 neural proliferation, differentiation and control, 1 -6.84177
CDC20 cell division cycle 20 -6.42424
KIF20A kinesin family member 20A -6.05488
PSRC1 proline/serine-rich coiled-coil 1 -5.68225
PLK1 polo-like kinase 1 -5.63778
KIF14 kinesin family member 14 -5.08546
TOP2A topoisomerase (DNA) II alpha 170kDa -4.94769
CCNB2 cyclin B2 -4.88719
NUSAP1 nucleolar and spindle associated protein 1 -4.40054
CCNB1 cyclin B1 -4.01499
AURKA aurora kinase A -3.87725
THAP11 THAP domain containing 11 -3.61764
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.61237
KIF4A kinesin family member 4A -3.48924
LBR lamin B receptor -3.42875
BASP1 brain abundant, membrane attached signal protein 1 -3.21133
TSPAN4 tetraspanin 4 -3.20509
CENPA centromere protein A -3.20122
ZNF263 zinc finger protein 263 -3.09982
TPX2 TPX2, microtubule-associated -3.00575
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.00019
HMMR hyaluronan-mediated motility receptor (RHAMM) -2.98665
CDCA3 cell division cycle associated 3 -2.98552
PRC1 protein regulator of cytokinesis 1 -2.8708
NEK2 NIMA-related kinase 2 -2.85843
OIP5 Opa interacting protein 5 -2.82501
MAT2A methionine adenosyltransferase II, alpha -2.7746
YKT6 YKT6 v-SNARE homolog (S. cerevisiae) -2.76146
CDCA8 cell division cycle associated 8 -2.75992
BORA bora, aurora kinase A activator -2.75796
PTTG1 pituitary tumor-transforming 1 -2.74975
PCF11 PCF11 cleavage and polyadenylation factor subunit -2.73447
UBE2S ubiquitin-conjugating enzyme E2S -2.61579
BIRC5 baculoviral IAP repeat containing 5 -2.58041
GARRE1 granule associated Rac and RHOG effector 1 -2.5452
NDC80 NDC80 kinetochore complex component -2.39734
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.39495
INTS8 integrator complex subunit 8 -2.37007
CCNA2 cyclin A2 -2.34959
KDM3A lysine (K)-specific demethylase 3A -2.34305
MTERF3 mitochondrial transcription termination factor 3 -2.33681
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.26623
CDC25B cell division cycle 25B -2.26556
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.26056
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.2455
JMJD6 jumonji domain containing 6 -2.23924
CDKN3 cyclin-dependent kinase inhibitor 3 -2.20789
KRT14 keratin 14, type I -2.18597
IP6K2 inositol hexakisphosphate kinase 2 -2.18597
CDC25C cell division cycle 25C -2.18556
CENPF centromere protein F, 350/400kDa -2.18204
KIF23 kinesin family member 23 -2.17714
RACGAP1 Rac GTPase activating protein 1 -2.16946
HJURP Holliday junction recognition protein -2.16818
CKAP2 cytoskeleton associated protein 2 -2.13941
DCP1A decapping mRNA 1A -2.13384
TRIB1 tribbles pseudokinase 1 -2.13353
HSPA8 heat shock 70kDa protein 8 -2.11871
TROAP trophinin associated protein -2.11471
ANKRD10 ankyrin repeat domain 10 -2.11139
KATNA1 katanin p60 (ATPase containing) subunit A 1 -2.08449
E2F6 E2F transcription factor 6 -2.08272
SOCS5 suppressor of cytokine signaling 5 -2.05844
MED27 mediator complex subunit 27 -2.05709
SPAST spastin -2.05437
CHORDC1 cysteine and histidine-rich domain (CHORD) containing 1 -2.05234
INSIG1 insulin induced gene 1 -2.05201
CHKA choline kinase alpha -2.03212
PBK PDZ binding kinase -2.02798
NCAPD2 non-SMC condensin I complex, subunit D2 -2.02644
HOXA5 homeobox A5 -2.01694
ZFTA zinc finger translocation associated -2.00602
HSPA1A heat shock 70kDa protein 1A -2.00477