CRCGN017_MCF10A.TP53.M_24H:F23 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methotrexate 33.12 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

115 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F23 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.6016
SLC1A4 solute carrier family 1 (glutamate/neutral amino acid transporter), member 4 4.06854
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 3.87582
TICAM1 toll-like receptor adaptor molecule 1 3.26504
ADO 2-aminoethanethiol (cysteamine) dioxygenase 3.26488
AGR2 anterior gradient 2 3.238
COMP cartilage oligomeric matrix protein 3.12375
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.04107
CNRIP1 cannabinoid receptor interacting protein 1 2.93591
CDC45 cell division cycle 45 2.91808
ABHD6 abhydrolase domain containing 6 2.91639
CYB5R1 cytochrome b5 reductase 1 2.84601
TCEA2 transcription elongation factor A (SII), 2 2.66861
MINDY1 MINDY lysine 48 deubiquitinase 1 2.66048
SKIC2 SKI2 subunit of superkiller complex 2.59423
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 2.55443
GADD45A growth arrest and DNA-damage-inducible, alpha 2.53728
DHRS2 dehydrogenase/reductase (SDR family) member 2 2.52498
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.49328
CIRBP cold inducible RNA binding protein 2.36456
PDLIM1 PDZ and LIM domain 1 2.34595
GNA15 guanine nucleotide binding protein (G protein), alpha 15 (Gq class) 2.32229
SLC45A2 solute carrier family 45, member 2 2.30878
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.28341
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 2.26267
RGS2 regulator of G-protein signaling 2 2.24223
DUSP11 dual specificity phosphatase 11 (RNA/RNP complex 1-interacting) 2.19322
IL1B interleukin 1, beta 2.18949
METTL22 methyltransferase like 22 2.15883
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.0945
SLC8B1 solute carrier family 8 (sodium/lithium/calcium exchanger), member B1 2.06594
AMDHD2 amidohydrolase domain containing 2 2.05571
DDTL D-dopachrome tautomerase-like 2.05328
MCM5 minichromosome maintenance complex component 5 2.04906
SPECC1L sperm antigen with calponin homology and coiled-coil domains 1-like 2.03466
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.03136
MYH9 myosin, heavy chain 9, non-muscle 2.0045

decreased expression

Symbol Name Standardized Value
CDC20 cell division cycle 20 -7.01709
KIF20A kinesin family member 20A -6.93088
UBE2C ubiquitin-conjugating enzyme E2C -6.87589
PLK1 polo-like kinase 1 -5.84026
PSRC1 proline/serine-rich coiled-coil 1 -5.22049
CCNB2 cyclin B2 -5.11795
KIF14 kinesin family member 14 -4.65249
TOP2A topoisomerase (DNA) II alpha 170kDa -4.56357
HMMR hyaluronan-mediated motility receptor (RHAMM) -4.24121
CCNB1 cyclin B1 -4.07252
LBR lamin B receptor -3.92962
AURKA aurora kinase A -3.81517
TSEN2 TSEN2 tRNA splicing endonuclease subunit -3.65218
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.40199
TMEM50A transmembrane protein 50A -3.34815
TPX2 TPX2, microtubule-associated -3.08428
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.08068
PIBF1 progesterone immunomodulatory binding factor 1 -3.06245
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.00348
NEK2 NIMA-related kinase 2 -2.92357
BIRC5 baculoviral IAP repeat containing 5 -2.91696
JMJD6 jumonji domain containing 6 -2.90589
PTTG1 pituitary tumor-transforming 1 -2.82808
NUSAP1 nucleolar and spindle associated protein 1 -2.77799
HJURP Holliday junction recognition protein -2.77198
NOP16 NOP16 nucleolar protein -2.77143
CDCA3 cell division cycle associated 3 -2.75629
NDC80 NDC80 kinetochore complex component -2.74342
CDC25C cell division cycle 25C -2.74202
KIF4A kinesin family member 4A -2.73282
CENPA centromere protein A -2.72609
DEPDC1 DEP domain containing 1 -2.71095
MT1X metallothionein 1X -2.70077
CDC25B cell division cycle 25B -2.67849
ANKRD10 ankyrin repeat domain 10 -2.67694
GARRE1 granule associated Rac and RHOG effector 1 -2.64523
SACM1L SAC1 suppressor of actin mutations 1-like (yeast) -2.6448
KIF18A kinesin family member 18A -2.6415
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.63068
HSPA1A heat shock 70kDa protein 1A -2.57579
MAT2A methionine adenosyltransferase II, alpha -2.52986
GRWD1 glutamate-rich WD repeat containing 1 -2.52757
SPC25 SPC25, NDC80 kinetochore complex component -2.52098
SNRPB2 small nuclear ribonucleoprotein polypeptide B -2.52032
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -2.51395
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) -2.49569
TTK TTK protein kinase -2.48382
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -2.46131
NCAPD2 non-SMC condensin I complex, subunit D2 -2.45698
SDF2 stromal cell-derived factor 2 -2.43106
HOXA5 homeobox A5 -2.39469
CENPE centromere protein E, 312kDa -2.38926
PCNA proliferating cell nuclear antigen -2.32469
FASTKD5 FAST kinase domains 5 -2.28845
UIMC1 ubiquitin interaction motif containing 1 -2.22656
MT1G metallothionein 1G -2.22281
DPY19L1 dpy-19-like 1 (C. elegans) -2.211
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.20888
SSB Sjogren syndrome antigen B (autoantigen La) -2.20204
ITPA inosine triphosphatase (nucleoside triphosphate pyrophosphatase) -2.19781
KIF11 kinesin family member 11 -2.19761
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -2.19416
DCP1A decapping mRNA 1A -2.1785
MNAT1 MNAT CDK-activating kinase assembly factor 1 -2.17023
CEP55 centrosomal protein 55kDa -2.1116
KIF23 kinesin family member 23 -2.09206
CCNA2 cyclin A2 -2.0686
ATP11B ATPase, class VI, type 11B -2.06233
NUP93 nucleoporin 93kDa -2.05474
MT1H metallothionein 1H -2.0509
CDKN3 cyclin-dependent kinase inhibitor 3 -2.04737
PSMC4 proteasome (prosome, macropain) 26S subunit, ATPase, 4 -2.03669
CDCA8 cell division cycle associated 8 -2.03451
PCOLCE2 procollagen C-endopeptidase enhancer 2 -2.03153
PSMB3 proteasome (prosome, macropain) subunit, beta type, 3 -2.02857
METTL4 methyltransferase like 4 -2.02591
PTPN12 protein tyrosine phosphatase, non-receptor type 12 -2.02293
SQSTM1 sequestosome 1 -2.0015