CRCGN017_MCF10A.TP53.M_24H:F24 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methotrexate 11.04 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

163 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:F24 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
COMP cartilage oligomeric matrix protein 4.98795
ST6GALNAC2 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2 4.90037
PTGS2 prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) 4.88678
SLC27A3 solute carrier family 27 (fatty acid transporter), member 3 4.03542
ABHD6 abhydrolase domain containing 6 3.94417
TICAM1 toll-like receptor adaptor molecule 1 3.56291
MINDY1 MINDY lysine 48 deubiquitinase 1 3.39255
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 3.09817
MCM5 minichromosome maintenance complex component 5 3.06582
CNRIP1 cannabinoid receptor interacting protein 1 3.05108
AMDHD2 amidohydrolase domain containing 2 3.0206
FGFR4 fibroblast growth factor receptor 4 3.00805
POLA2 polymerase (DNA directed), alpha 2, accessory subunit 2.69185
RBKS ribokinase 2.64739
HBA1 hemoglobin, alpha 1 2.64363
SKIC2 SKI2 subunit of superkiller complex 2.61239
FN3KRP fructosamine 3 kinase related protein 2.60995
SH3GLB2 SH3-domain GRB2-like endophilin B2 2.50548
TCEA2 transcription elongation factor A (SII), 2 2.47855
CIDEB cell death-inducing DFFA-like effector b 2.47647
CAPN1 calpain 1, (mu/I) large subunit 2.47014
PAFAH1B3 platelet-activating factor acetylhydrolase 1b, catalytic subunit 3 (29kDa) 2.47001
APOL6 apolipoprotein L, 6 2.45937
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) 2.39599
RGS2 regulator of G-protein signaling 2 2.38797
UNG uracil-DNA glycosylase 2.35581
SCCPDH saccharopine dehydrogenase (putative) 2.34888
RARRES2 retinoic acid receptor responder (tazarotene induced) 2 2.29616
CDC45 cell division cycle 45 2.28543
UBR7 ubiquitin protein ligase E3 component n-recognin 7 (putative) 2.25486
TAX1BP3 Tax1 (human T-cell leukemia virus type I) binding protein 3 2.24344
IFI27 interferon, alpha-inducible protein 27 2.23208
LINC02762 long intergenic non-protein coding RNA 2762 2.20115
ACAA1 acetyl-CoA acyltransferase 1 2.16717
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa 2.16575
MAPK3 mitogen-activated protein kinase 3 2.15506
IL1B interleukin 1, beta 2.13161
INAVA innate immunity activator 2.12296
MPDU1 mannose-P-dolichol utilization defect 1 2.11988
DCK deoxycytidine kinase 2.1093
QDPR quinoid dihydropteridine reductase 2.09448
GET1 guided entry of tail-anchored proteins factor 1 2.07549
REEP1 receptor accessory protein 1 2.07446
EPHX3 epoxide hydrolase 3 2.06048
SPATA20 spermatogenesis associated 20 2.0546
CYB5R3 cytochrome b5 reductase 3 2.05194
BACE2 beta-site APP-cleaving enzyme 2 2.0472
SLC25A4 solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 4 2.04688
TSPAN1 tetraspanin 1 2.03889
BHLHE40 basic helix-loop-helix family, member e40 2.03576
PSMD10 proteasome (prosome, macropain) 26S subunit, non-ATPase, 10 2.02809

decreased expression

Symbol Name Standardized Value
KIF20A kinesin family member 20A -6.6298
PSRC1 proline/serine-rich coiled-coil 1 -6.5537
UBE2C ubiquitin-conjugating enzyme E2C -6.54766
PLK1 polo-like kinase 1 -6.29095
CDC20 cell division cycle 20 -6.17542
CDKN1B cyclin-dependent kinase inhibitor 1B (p27, Kip1) -5.47613
TOP2A topoisomerase (DNA) II alpha 170kDa -4.99425
CCNB1 cyclin B1 -4.67843
KIF14 kinesin family member 14 -4.67733
AURKA aurora kinase A -4.40323
HMG20B high mobility group 20B -4.19705
NCAPD2 non-SMC condensin I complex, subunit D2 -4.08553
HMMR hyaluronan-mediated motility receptor (RHAMM) -3.82172
LBR lamin B receptor -3.68055
CCNB2 cyclin B2 -3.66062
ASPM asp (abnormal spindle) homolog, microcephaly associated (Drosophila) -3.63104
TSPAN4 tetraspanin 4 -3.48791
DLGAP5 discs, large (Drosophila) homolog-associated protein 5 -3.42248
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.34598
TIMM9 translocase of inner mitochondrial membrane 9 homolog (yeast) -3.33998
CDCA3 cell division cycle associated 3 -3.32445
NOP16 NOP16 nucleolar protein -3.28668
NEK2 NIMA-related kinase 2 -3.23703
CENPA centromere protein A -3.18472
HJURP Holliday junction recognition protein -3.16813
KIF23 kinesin family member 23 -3.15305
ZNF146 zinc finger protein 146 -3.13268
KIF11 kinesin family member 11 -3.06093
KPNA2 karyopherin alpha 2 (RAG cohort 1, importin alpha 1) -3.05059
NDC80 NDC80 kinetochore complex component -3.02957
PDCD5 programmed cell death 5 -2.93986
KIF18A kinesin family member 18A -2.89743
BIRC5 baculoviral IAP repeat containing 5 -2.8914
KIF4A kinesin family member 4A -2.82348
NOP2 NOP2 nucleolar protein -2.79799
CDKN3 cyclin-dependent kinase inhibitor 3 -2.77236
DNAJC2 DnaJ (Hsp40) homolog, subfamily C, member 2 -2.77149
TSEN2 TSEN2 tRNA splicing endonuclease subunit -2.75568
SMNDC1 survival motor neuron domain containing 1 -2.7154
CDCA8 cell division cycle associated 8 -2.68509
CENPE centromere protein E, 312kDa -2.63983
TRMT13 tRNA methyltransferase 13 homolog (S. cerevisiae) -2.62308
PTTG1 pituitary tumor-transforming 1 -2.58089
CDC25B cell division cycle 25B -2.55084
LSM14A LSM14A, SCD6 homolog A (S. cerevisiae) -2.54456
CDC25C cell division cycle 25C -2.53592
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -2.5337
CEP55 centrosomal protein 55kDa -2.5329
LAMB1 laminin, beta 1 -2.50365
DEPDC1 DEP domain containing 1 -2.50036
GPATCH1 G patch domain containing 1 -2.47466
PARPBP PARP1 binding protein -2.45544
CENPF centromere protein F, 350/400kDa -2.4328
TPX2 TPX2, microtubule-associated -2.42685
HSPA1A heat shock 70kDa protein 1A -2.41291
BORA bora, aurora kinase A activator -2.39527
NUSAP1 nucleolar and spindle associated protein 1 -2.39212
ESF1 ESF1, nucleolar pre-rRNA processing protein, homolog (S. cerevisiae) -2.38415
BUB1 BUB1 mitotic checkpoint serine/threonine kinase -2.34704
TMED5 transmembrane emp24 protein transport domain containing 5 -2.34195
ARHGAP11A Rho GTPase activating protein 11A -2.33559
CCNF cyclin F -2.33286
MYC v-myc avian myelocytomatosis viral oncogene homolog -2.32546
XPO6 exportin 6 -2.32389
PIMREG PICALM interacting mitotic regulator -2.3021
PPP2R3C protein phosphatase 2, regulatory subunit B'', gamma -2.30126
JMJD6 jumonji domain containing 6 -2.29964
TROAP trophinin associated protein -2.29813
KIF18B kinesin family member 18B -2.28445
PTK2 protein tyrosine kinase 2 -2.28196
GOLGA6L9 golgin A6 family-like 9 -2.2481
NUFIP1 nuclear fragile X mental retardation protein interacting protein 1 -2.24571
TACC3 transforming, acidic coiled-coil containing protein 3 -2.24332
PRC1 protein regulator of cytokinesis 1 -2.24266
MKI67 marker of proliferation Ki-67 -2.22607
CCNA2 cyclin A2 -2.22465
THOC2 THO complex 2 -2.20701
KIAA0586 KIAA0586 -2.19395
INTS8 integrator complex subunit 8 -2.18672
SPC25 SPC25, NDC80 kinetochore complex component -2.18272
ECT2 epithelial cell transforming 2 -2.16312
WDR3 WD repeat domain 3 -2.1616
ZNHIT6 zinc finger, HIT-type containing 6 -2.15821
UBE2S ubiquitin-conjugating enzyme E2S -2.157
RPGRIP1L RPGRIP1-like -2.15252
NOP14 NOP14 nucleolar protein -2.14681
SPDL1 spindle apparatus coiled-coil protein 1 -2.13774
TWNK twinkle mtDNA helicase -2.13605
HOXA5 homeobox A5 -2.1339
GSPT1 G1 to S phase transition 1 -2.12849
PSME4 proteasome (prosome, macropain) activator subunit 4 -2.11768
MPHOSPH10 M-phase phosphoprotein 10 (U3 small nucleolar ribonucleoprotein) -2.11107
CILK1 ciliogenesis associated kinase 1 -2.10837
GRWD1 glutamate-rich WD repeat containing 1 -2.10323
ZC3H7A zinc finger CCCH-type containing 7A -2.10175
NKRF NFKB repressing factor -2.0876
EBAG9 estrogen receptor binding site associated, antigen, 9 -2.08559
UGGT2 UDP-glucose glycoprotein glucosyltransferase 2 -2.08253
BASP1 brain abundant, membrane attached signal protein 1 -2.06784
UTP20 UTP20, small subunit (SSU) processome component, homolog (yeast) -2.06009
NRF1 nuclear respiratory factor 1 -2.05589
PIBF1 progesterone immunomodulatory binding factor 1 -2.05168
NLK nemo-like kinase -2.05086
ZNF23 zinc finger protein 23 -2.04929
WNT10B wingless-type MMTV integration site family, member 10B -2.04421
MARK3 MAP/microtubule affinity-regulating kinase 3 -2.04398
KIF15 kinesin family member 15 -2.04282
UBR5 ubiquitin protein ligase E3 component n-recognin 5 -2.03742
ZNF587B zinc finger protein 587B -2.03642
NOL10 nucleolar protein 10 -2.01287
FJX1 four jointed box 1 (Drosophila) -2.01117
H2AJ H2A.J histone -2.00315