CRCGN017_MCF10A.TP53.M_24H:G01 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description tris(1-chloro-2-propanyl) phosphate 100.97 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
Similar Terms
Downloads & Tools

Genes

76 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G01 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
C2CD2 C2 calcium-dependent domain containing 2 5.1769
KDM5D lysine (K)-specific demethylase 5D 4.24355
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.6557
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 3.5206
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 3.34305
HYOU1 hypoxia up-regulated 1 3.2955
PLS1 plastin 1 3.25845
LOC102724023 ES1 protein homolog, mitochondrial 2.74605
DERL2 derlin 2 2.57115
TBPL1 TBP-like 1 2.55825
USP9Y ubiquitin specific peptidase 9, Y-linked 2.43062
ACBD3 acyl-CoA binding domain containing 3 2.3966
HERC6 HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 2.38005
EPN2 epsin 2 2.32477
RAB20 RAB20, member RAS oncogene family 2.31815
ACP3 acid phosphatase 3 2.30905
EPHB2 EPH receptor B2 2.3087
CNPY3 canopy FGF signaling regulator 3 2.3057
POLR2H polymerase (RNA) II (DNA directed) polypeptide H 2.29245
MRPL48 mitochondrial ribosomal protein L48 2.16125
CDK7 cyclin-dependent kinase 7 2.15125
MYH2 myosin, heavy chain 2, skeletal muscle, adult 2.1493
SRC SRC proto-oncogene, non-receptor tyrosine kinase 2.14435
TOP6BL TOP6B like initiator of meiotic double strand breaks 2.08195
ZNF148 zinc finger protein 148 2.05995
CAPZA1 capping protein (actin filament) muscle Z-line, alpha 1 2.05475
CHAC1 ChaC glutathione-specific gamma-glutamylcyclotransferase 1 2.04965
MRNIP MRN complex interacting protein 2.0347
ZCCHC24 zinc finger, CCHC domain containing 24 2.03395
SATB1 SATB homeobox 1 2.02505
GPN2 GPN-loop GTPase 2 2.0225
MX1 MX dynamin-like GTPase 1 2.02245
HDAC4 histone deacetylase 4 2.0214

decreased expression

Symbol Name Standardized Value
KRT14 keratin 14, type I -5.0
DNM1L dynamin 1-like -4.9381
PUF60 poly-U binding splicing factor 60KDa -4.84
PSMB8 proteasome (prosome, macropain) subunit, beta type, 8 -4.7416
MSN moesin -3.87865
SMC1A structural maintenance of chromosomes 1A -3.60285
NLRP4 NLR family, pyrin domain containing 4 -3.50845
CTNND1 catenin (cadherin-associated protein), delta 1 -3.43077
SPINT2 serine peptidase inhibitor, Kunitz type, 2 -3.21075
FAR2 fatty acyl CoA reductase 2 -3.0715
CD81 CD81 molecule -3.044
UBA1 ubiquitin-like modifier activating enzyme 1 -2.81835
YARS2 tyrosyl-tRNA synthetase 2, mitochondrial -2.7964
PSIP1 PC4 and SFRS1 interacting protein 1 -2.7948
OXA1L oxidase (cytochrome c) assembly 1-like -2.79095
TUBA4A tubulin, alpha 4a -2.5972
CDK4 cyclin-dependent kinase 4 -2.5534
KDM5C lysine (K)-specific demethylase 5C -2.5461
USP9X ubiquitin specific peptidase 9, X-linked -2.47892
IL21R interleukin 21 receptor -2.45108
TOMM70 translocase of outer mitochondrial membrane 70 -2.36635
TBX2 T-box 2 -2.3529
DDX3X DEAD (Asp-Glu-Ala-Asp) box helicase 3, X-linked -2.3507
TIE1 tyrosine kinase with immunoglobulin-like and EGF-like domains 1 -2.2864
KDM3A lysine (K)-specific demethylase 3A -2.27535
LOC124905557 eukaryotic translation initiation factor 1A, X-chromosomal -2.25946
CLIP4 CAP-GLY domain containing linker protein family, member 4 -2.21555
BRD7 bromodomain containing 7 -2.206
LRRC41 leucine rich repeat containing 41 -2.20205
IL2RG interleukin 2 receptor, gamma -2.18765
CAPRIN2 caprin family member 2 -2.185
KCNE4 potassium channel, voltage gated subfamily E regulatory beta subunit 4 -2.153
PNPLA4 patatin-like phospholipase domain containing 4 -2.13485
CCDC91 coiled-coil domain containing 91 -2.1313
AHCYL2 adenosylhomocysteinase-like 2 -2.1161
JAK1 Janus kinase 1 -2.0953
NIT2 nitrilase family, member 2 -2.04775
CNIH3 cornichon family AMPA receptor auxiliary protein 3 -2.04365
AXIN1 axin 1 -2.0385
RFTN1 raftlin, lipid raft linker 1 -2.0138
ITGA2B integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) -2.01142
PUDP pseudouridine 5'-phosphatase -2.0093
GAA glucosidase, alpha; acid -2.002