CRCGN017_MCF10A.TP53.M_24H:G04 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dichloroethane 97.43 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

35 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G04 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
KDM5A lysine (K)-specific demethylase 5A 4.2265
KIF5C kinesin family member 5C 3.5498
WDR7 WD repeat domain 7 3.34459
BPHL biphenyl hydrolase-like (serine hydrolase) 2.9814
CCNF cyclin F 2.78693
MMUT methylmalonyl-CoA mutase 2.51711
TIPRL TOR signaling pathway regulator 2.43235
NOTCH1 notch 1 2.35804
PAM16 presequence translocase-associated motor 16 homolog (S. cerevisiae) 2.32364
KAT6B K(lysine) acetyltransferase 6B 2.23298
KIT v-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog 2.22443
SHROOM2 shroom family member 2 2.13277
NVL nuclear VCP-like 2.10654
ACVR2B activin A receptor, type IIB 2.07722
SLCO2A1 solute carrier organic anion transporter family, member 2A1 2.0662
ZNF451 zinc finger protein 451 2.05691
RHOBTB2 Rho-related BTB domain containing 2 2.05459
FLRT1 fibronectin leucine rich transmembrane protein 1 2.03911
MSRA methionine sulfoxide reductase A 2.03608
CRBN cereblon 2.0148
ARHGEF9 Cdc42 guanine nucleotide exchange factor (GEF) 9 2.00679

decreased expression

Symbol Name Standardized Value
OXA1L oxidase (cytochrome c) assembly 1-like -5.33366
TARBP1 TAR (HIV-1) RNA binding protein 1 -4.7385
PCNA proliferating cell nuclear antigen -4.71296
DHRS7 dehydrogenase/reductase (SDR family) member 7 -4.68933
TM9SF3 transmembrane 9 superfamily member 3 -4.56058
HOXA5 homeobox A5 -4.37199
HAT1 histone acetyltransferase 1 -4.36623
AKR7A2 aldo-keto reductase family 7, member A2 (aflatoxin aldehyde reductase) -3.75949
NUSAP1 nucleolar and spindle associated protein 1 -3.64114
DUSP14 dual specificity phosphatase 14 -2.83214
ZWINT ZW10 interacting kinetochore protein -2.53434
CDC42 cell division cycle 42 -2.2601
CANT1 calcium activated nucleotidase 1 -2.04562
LRRN3 leucine rich repeat neuronal 3 -2.03993