CRCGN017_MCF10A.TP53.M_24H:G06 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1,1-dichloroethane 10.83 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

41 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G06 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
CNRIP1 cannabinoid receptor interacting protein 1 3.5503
E2F2 E2F transcription factor 2 3.46128
EIF1AY eukaryotic translation initiation factor 1A, Y-linked 3.37427
CETN3 centrin, EF-hand protein, 3 3.2013
KDM5D lysine (K)-specific demethylase 5D 3.11269
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 3.03864
DDX3Y DEAD (Asp-Glu-Ala-Asp) box helicase 3, Y-linked 2.77693
USP9Y ubiquitin specific peptidase 9, Y-linked 2.65871
SLC15A2 solute carrier family 15 (oligopeptide transporter), member 2 2.2923
SULT1E1 sulfotransferase family 1E, estrogen-preferring, member 1 2.21309
HBA1 hemoglobin, alpha 1 2.19199
TLCD3A TLC domain containing 3A 2.16961
PRKAA1 protein kinase, AMP-activated, alpha 1 catalytic subunit 2.12724
UTY ubiquitously transcribed tetratricopeptide repeat containing, Y-linked 2.12674
TSG101 tumor susceptibility 101 2.09362
RRP8 ribosomal RNA processing 8, methyltransferase, homolog (yeast) 2.04751
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.04458
ZFY zinc finger protein, Y-linked 2.01898
ACYP2 acylphosphatase 2, muscle type 2.00415

decreased expression

Symbol Name Standardized Value
MRPS2 mitochondrial ribosomal protein S2 -4.34578
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -4.31729
CDC45 cell division cycle 45 -3.90199
PAEP progestagen-associated endometrial protein -3.33007
CANT1 calcium activated nucleotidase 1 -3.26176
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.88806
KDM5C lysine (K)-specific demethylase 5C -2.86341
UBA1 ubiquitin-like modifier activating enzyme 1 -2.7983
UFM1 ubiquitin-fold modifier 1 -2.77243
SMC1A structural maintenance of chromosomes 1A -2.75532
RPIA ribose 5-phosphate isomerase A -2.68688
TRIB3 tribbles pseudokinase 3 -2.53177
PCNA proliferating cell nuclear antigen -2.45242
DYNLT3 dynein, light chain, Tctex-type 3 -2.35679
VDAC1 voltage-dependent anion channel 1 -2.31268
ZRSR2 zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2 -2.30598
TIMP1 TIMP metallopeptidase inhibitor 1 -2.19286
SEC16A SEC16 homolog A (S. cerevisiae) -2.12965
PUDP pseudouridine 5'-phosphatase -2.1185
CD320 CD320 molecule -2.11296
MED22 mediator complex subunit 22 -2.04924
MAN1B1 mannosidase, alpha, class 1B, member 1 -2.01012