CRCGN017_MCF10A.TP53.M_24H:G08 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenyl-2-thiourea 34.16 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

19 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G08 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
STAP2 signal transducing adaptor family member 2 5.04377
MAMLD1 mastermind-like domain containing 1 4.85844
SPAG4 sperm associated antigen 4 4.79075
KLHL9 kelch-like family member 9 3.76235
PHKA1 phosphorylase kinase, alpha 1 (muscle) 3.08064
DYRK3 dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 3 3.05157
MELK maternal embryonic leucine zipper kinase 2.56419
TCFL5 transcription factor-like 5 (basic helix-loop-helix) 2.24454

decreased expression

Symbol Name Standardized Value
KIF14 kinesin family member 14 -4.89054
C2CD5 C2 calcium-dependent domain containing 5 -4.76451
MSMO1 methylsterol monooxygenase 1 -3.89279
NPDC1 neural proliferation, differentiation and control, 1 -3.60138
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -3.43824
XPNPEP1 X-prolyl aminopeptidase (aminopeptidase P) 1, soluble -3.13655
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -3.086
TBCB tubulin folding cofactor B -2.18671
PSENEN presenilin enhancer gamma secretase subunit -2.14869
TMEM147 transmembrane protein 147 -2.01751
RPP38 ribonuclease P/MRP 38kDa subunit -2.01296