CRCGN017_MCF10A.TP53.M_24H:G09 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 1-phenyl-2-thiourea 11.39 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

33 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G09 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SPAG4 sperm associated antigen 4 3.67557
ABCC5 ATP-binding cassette, sub-family C (CFTR/MRP), member 5 3.37274
AGR2 anterior gradient 2 3.34515
EDEM1 ER degradation enhancer, mannosidase alpha-like 1 2.87146
ADO 2-aminoethanethiol (cysteamine) dioxygenase 2.68997
FGFR4 fibroblast growth factor receptor 4 2.67464
CEBPD CCAAT/enhancer binding protein (C/EBP), delta 2.46989
HBB hemoglobin, beta 2.42039
SLC30A9 solute carrier family 30 (zinc transporter), member 9 2.35841
CGRRF1 cell growth regulator with ring finger domain 1 2.20238
COMP cartilage oligomeric matrix protein 2.19094
ACAA1 acetyl-CoA acyltransferase 1 2.07853
CYB5A cytochrome b5 type A (microsomal) 2.0614
EPHB2 EPH receptor B2 2.01746

decreased expression

Symbol Name Standardized Value
TM9SF3 transmembrane 9 superfamily member 3 -4.20899
PCNA proliferating cell nuclear antigen -3.37567
NGRN neugrin, neurite outgrowth associated -3.36296
HMG20B high mobility group 20B -3.16214
CD58 CD58 molecule -3.10102
TRAPPC3 trafficking protein particle complex 3 -2.93407
TES testin LIM domain protein -2.76024
CAB39 calcium binding protein 39 -2.73472
CDC20 cell division cycle 20 -2.58067
TUBA4A tubulin, alpha 4a -2.52749
KDM3A lysine (K)-specific demethylase 3A -2.50289
ISOC1 isochorismatase domain containing 1 -2.48636
KIZ kizuna centrosomal protein -2.46574
TARBP1 TAR (HIV-1) RNA binding protein 1 -2.42247
HSPA8 heat shock 70kDa protein 8 -2.38702
CORO1A coronin, actin binding protein, 1A -2.33322
RBM34 RNA binding motif protein 34 -2.27207
BECN1 beclin 1, autophagy related -2.13468
QTRT1 queuine tRNA-ribosyltransferase 1 -2.03565