| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | sirolimus 10.0 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
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94 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G16 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| AGR2 | anterior gradient 2 | 5.67442 |
| CCP110 | centriolar coiled coil protein 110kDa | 4.17548 |
| RBKS | ribokinase | 4.15596 |
| SPAG4 | sperm associated antigen 4 | 3.5396 |
| SNAP25 | synaptosomal-associated protein, 25kDa | 3.35459 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 3.10738 |
| SLC25A14 | solute carrier family 25 (mitochondrial carrier, brain), member 14 | 3.09506 |
| HMGA2 | high mobility group AT-hook 2 | 3.07816 |
| MAMLD1 | mastermind-like domain containing 1 | 3.07462 |
| FHL2 | four and a half LIM domains 2 | 3.00048 |
| SQSTM1 | sequestosome 1 | 2.97034 |
| CCNA1 | cyclin A1 | 2.86227 |
| RELB | v-rel avian reticuloendotheliosis viral oncogene homolog B | 2.79664 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.76523 |
| SCCPDH | saccharopine dehydrogenase (putative) | 2.51038 |
| DENND2D | DENN/MADD domain containing 2D | 2.48601 |
| TXNRD1 | thioredoxin reductase 1 | 2.44748 |
| SNX11 | sorting nexin 11 | 2.43064 |
| SLC75A1 | solute carrier family 75 member 1 | 2.42828 |
| PRAF2 | PRA1 domain family, member 2 | 2.37004 |
| IER3 | immediate early response 3 | 2.32952 |
| NUDT9 | nudix (nucleoside diphosphate linked moiety X)-type motif 9 | 2.30915 |
| TSPAN4 | tetraspanin 4 | 2.30663 |
| GAA | glucosidase, alpha; acid | 2.29839 |
| NOP53 | NOP53 ribosome biogenesis factor | 2.26679 |
| COQ8A | coenzyme Q8A | 2.26533 |
| GCLM | glutamate-cysteine ligase, modifier subunit | 2.23958 |
| POLD4 | polymerase (DNA-directed), delta 4, accessory subunit | 2.22684 |
| GARRE1 | granule associated Rac and RHOG effector 1 | 2.21594 |
| SERPINE1 | serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1 | 2.17668 |
| MOK | MOK protein kinase | 2.1629 |
| RPN1 | ribophorin I | 2.15415 |
| KIFBP | kinesin family binding protein | 2.14938 |
| ARID4B | AT rich interactive domain 4B (RBP1-like) | 2.12664 |
| FAH | fumarylacetoacetate hydrolase (fumarylacetoacetase) | 2.11484 |
| RRS1 | RRS1 ribosome biogenesis regulator homolog (S. cerevisiae) | 2.11019 |
| CD3E | CD3e molecule, epsilon (CD3-TCR complex) | 2.10027 |
| CEP170 | centrosomal protein 170kDa | 2.07868 |
| GRN | granulin | 2.07825 |
| MGST3 | microsomal glutathione S-transferase 3 | 2.07612 |
| SQOR | sulfide quinone oxidoreductase | 2.05984 |
| NDUFV1 | NADH dehydrogenase (ubiquinone) flavoprotein 1, 51kDa | 2.04834 |
| LAGE3 | L antigen family, member 3 | 2.0462 |
| CHIC2 | cysteine-rich hydrophobic domain 2 | 2.03692 |
| AXIN1 | axin 1 | 2.02243 |
| CTSL | cathepsin L | 2.02105 |
| CD5L | CD5 molecule-like | 2.01031 |
| DUSP6 | dual specificity phosphatase 6 | 2.00525 |
| TM9SF3 | transmembrane 9 superfamily member 3 | 2.00375 |
| FOSL1 | FOS-like antigen 1 | 2.00219 |
| Symbol | Name | Standardized Value |
|---|---|---|
| DDIT4 | DNA-damage-inducible transcript 4 | -4.17844 |
| PRR15L | proline rich 15-like | -3.98425 |
| TSC22D3 | TSC22 domain family, member 3 | -3.91746 |
| MSMO1 | methylsterol monooxygenase 1 | -3.64007 |
| C2CD5 | C2 calcium-dependent domain containing 5 | -3.62349 |
| INSIG1 | insulin induced gene 1 | -3.28894 |
| HACD3 | 3-hydroxyacyl-CoA dehydratase 3 | -3.23216 |
| INPP4B | inositol polyphosphate-4-phosphatase, type II, 105kDa | -3.09372 |
| HSPB1 | heat shock 27kDa protein 1 | -3.09209 |
| TRIB3 | tribbles pseudokinase 3 | -3.05253 |
| HMGCS1 | 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) | -2.87788 |
| TOR1B | torsin family 1, member B (torsin B) | -2.85458 |
| PCNA | proliferating cell nuclear antigen | -2.79407 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.71168 |
| SLC35A1 | solute carrier family 35 (CMP-sialic acid transporter), member A1 | -2.40795 |
| RGS2 | regulator of G-protein signaling 2 | -2.3694 |
| PEX13 | peroxisomal biogenesis factor 13 | -2.34361 |
| TOR1A | torsin family 1, member A (torsin A) | -2.34185 |
| ZNF195 | zinc finger protein 195 | -2.33351 |
| CDS2 | CDP-diacylglycerol synthase (phosphatidate cytidylyltransferase) 2 | -2.32245 |
| S100A4 | S100 calcium binding protein A4 | -2.30228 |
| PIK3R3 | phosphoinositide-3-kinase, regulatory subunit 3 (gamma) | -2.28457 |
| DNM1L | dynamin 1-like | -2.27397 |
| CHN1 | chimerin 1 | -2.26174 |
| MFN1 | mitofusin 1 | -2.242 |
| ARFIP2 | ADP-ribosylation factor interacting protein 2 | -2.24047 |
| PRKCD | protein kinase C, delta | -2.20505 |
| TOPBP1 | topoisomerase (DNA) II binding protein 1 | -2.19952 |
| CLIC3 | chloride intracellular channel 3 | -2.16803 |
| EFNA4 | ephrin-A4 | -2.14895 |
| NSDHL | NAD(P) dependent steroid dehydrogenase-like | -2.13852 |
| EHF | ets homologous factor | -2.08815 |
| IDH3B | isocitrate dehydrogenase 3 (NAD+) beta | -2.08798 |
| ILK | integrin-linked kinase | -2.07334 |
| ANKRD10 | ankyrin repeat domain 10 | -2.06037 |
| LBR | lamin B receptor | -2.04413 |
| TMEM126B | transmembrane protein 126B | -2.03796 |
| KLF4 | Kruppel-like factor 4 (gut) | -2.03116 |
| SYNE2 | spectrin repeat containing, nuclear envelope 2 | -2.02941 |
| FGL2 | fibrinogen-like 2 | -2.02214 |
| YAP1 | Yes-associated protein 1 | -2.02174 |
| WDR41 | WD repeat domain 41 | -2.01767 |
| CARS1 | cysteinyl-tRNA synthetase 1 | -2.01698 |
| PSMD5 | proteasome (prosome, macropain) 26S subunit, non-ATPase, 5 | -2.00316 |
