CRCGN017_MCF10A.TP53.M_24H:G17 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description sirolimus 3.33 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

98 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G17 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MAMLD1 mastermind-like domain containing 1 6.07938
CXCL2 chemokine (C-X-C motif) ligand 2 4.77193
STK10 serine/threonine kinase 10 3.76794
C2CD2 C2 calcium-dependent domain containing 2 3.64972
NUDT9 nudix (nucleoside diphosphate linked moiety X)-type motif 9 3.09994
TSPAN4 tetraspanin 4 3.02184
CHIC2 cysteine-rich hydrophobic domain 2 2.80951
PDLIM1 PDZ and LIM domain 1 2.66859
FHL2 four and a half LIM domains 2 2.64189
HMGA2 high mobility group AT-hook 2 2.56721
MYC v-myc avian myelocytomatosis viral oncogene homolog 2.53324
EIF3L eukaryotic translation initiation factor 3, subunit L 2.49929
AGR2 anterior gradient 2 2.46015
COMP cartilage oligomeric matrix protein 2.37259
IGF2BP2 insulin-like growth factor 2 mRNA binding protein 2 2.35579
HMGN2 high mobility group nucleosomal binding domain 2 2.25802
SCCPDH saccharopine dehydrogenase (putative) 2.25199
KIFBP kinesin family binding protein 2.18149
DUSP6 dual specificity phosphatase 6 2.18128
CEP57 centrosomal protein 57kDa 2.1801
KLHL9 kelch-like family member 9 2.17822
CDCA4 cell division cycle associated 4 2.16921
TNIP1 TNFAIP3 interacting protein 1 2.1631
CASP10 caspase 10, apoptosis-related cysteine peptidase 2.13345
PIGN phosphatidylinositol glycan anchor biosynthesis, class N 2.09544
ERCC1 excision repair cross-complementation group 1 2.06881
HDLBP high density lipoprotein binding protein 2.06343
INPP5E inositol polyphosphate-5-phosphatase, 72 kDa 2.05184
NSA2 NSA2 ribosome biogenesis homolog (S. cerevisiae) 2.04814
PTGER2 prostaglandin E receptor 2 (subtype EP2), 53kDa 2.04589
SAV1 salvador family WW domain containing protein 1 2.03072
IFNB1 interferon, beta 1, fibroblast 2.02143
BGLAP bone gamma-carboxyglutamate (gla) protein 2.01604
NDUFAF3 NADH dehydrogenase (ubiquinone) complex I, assembly factor 3 2.01157
AMOTL2 angiomotin like 2 2.00243
NT5E 5'-nucleotidase, ecto (CD73) 2.00235

decreased expression

Symbol Name Standardized Value
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -4.44486
LDHD lactate dehydrogenase D -4.37095
MSMO1 methylsterol monooxygenase 1 -3.99878
ADI1 acireductone dioxygenase 1 -3.88802
PUF60 poly-U binding splicing factor 60KDa -3.85017
TUBA4A tubulin, alpha 4a -3.83492
DYNLT3 dynein, light chain, Tctex-type 3 -3.70212
PRR15L proline rich 15-like -3.18228
TXNDC9 thioredoxin domain containing 9 -3.05074
DDIT4 DNA-damage-inducible transcript 4 -2.97997
SMAP1 small ArfGAP 1 -2.97751
ITGAE integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) -2.91672
LYPLA1 lysophospholipase I -2.91033
DCK deoxycytidine kinase -2.91007
RAB5IF RAB5 interacting factor -2.85945
HSPB1 heat shock 27kDa protein 1 -2.83028
KRT14 keratin 14, type I -2.82322
SNCA synuclein, alpha (non A4 component of amyloid precursor) -2.74157
ATP6V1H ATPase, H+ transporting, lysosomal 50/57kDa, V1 subunit H -2.73754
ALDOC aldolase C, fructose-bisphosphate -2.73248
RIPPLY2-CYB5R4 RIPPLY2-CYB5R4 readthrough -2.63594
CA2 carbonic anhydrase II -2.52934
DNAJC15 DnaJ (Hsp40) homolog, subfamily C, member 15 -2.49893
IRAK4 interleukin-1 receptor-associated kinase 4 -2.4984
NDUFS1 NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase) -2.49701
MMADHC methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria -2.48097
PSMD7 proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 -2.47775
ETFA electron-transfer-flavoprotein, alpha polypeptide -2.43356
S100A4 S100 calcium binding protein A4 -2.42511
PDCD10 programmed cell death 10 -2.41587
BNIP2 BCL2/adenovirus E1B 19kDa interacting protein 2 -2.39664
ZFAND1 zinc finger, AN1-type domain 1 -2.38701
INSIG1 insulin induced gene 1 -2.37638
CARS1 cysteinyl-tRNA synthetase 1 -2.36758
NFS1 NFS1 cysteine desulfurase -2.36025
LSM8 LSM8 homolog, U6 small nuclear RNA associated (S. cerevisiae) -2.33475
PRELID3B PRELI domain containing 3B -2.32768
MLLT11 myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 -2.30899
SLC35A1 solute carrier family 35 (CMP-sialic acid transporter), member A1 -2.30568
ANAPC10 anaphase promoting complex subunit 10 -2.30026
COMMD8 COMM domain containing 8 -2.27076
UBE2V2 ubiquitin-conjugating enzyme E2 variant 2 -2.25953
BLTP3B bridge-like lipid transfer protein family member 3B -2.25242
DPM1 dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit -2.25217
INPP4B inositol polyphosphate-4-phosphatase, type II, 105kDa -2.24803
SESN1 sestrin 1 -2.24058
PSMD6 proteasome (prosome, macropain) 26S subunit, non-ATPase, 6 -2.22569
IMMT inner membrane protein, mitochondrial -2.21195
MPC1 mitochondrial pyruvate carrier 1 -2.20794
CHN1 chimerin 1 -2.20495
ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A -2.1893
OXR1 oxidation resistance 1 -2.18109
HIGD1A HIG1 hypoxia inducible domain family, member 1A -2.11298
NSF N-ethylmaleimide-sensitive factor -2.10814
ZNF184 zinc finger protein 184 -2.10003
RGS2 regulator of G-protein signaling 2 -2.08137
CCNC cyclin C -2.08072
EXOC1 exocyst complex component 1 -2.0682
FAM32A family with sequence similarity 32, member A -2.06413
IMPA1 inositol(myo)-1(or 4)-monophosphatase 1 -2.03006
ZNF273 zinc finger protein 273 -2.01028
ATP6V0B ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b -2.01003