| Dataset | Carcinogenome Chemical Perturbation Carcinogenicity Signatures |
| Category | transcriptomics |
| Type | small molecule perturbation |
| Description | sirolimus 1.11 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome) |
| Similar Terms | |
| Downloads & Tools |
74 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G18 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.
| Symbol | Name | Standardized Value |
|---|---|---|
| SPAG4 | sperm associated antigen 4 | 6.97313 |
| MAMLD1 | mastermind-like domain containing 1 | 3.74735 |
| KLHL21 | kelch-like family member 21 | 3.35901 |
| SCCPDH | saccharopine dehydrogenase (putative) | 3.23821 |
| CCDC92 | coiled-coil domain containing 92 | 3.20319 |
| AGR2 | anterior gradient 2 | 3.1986 |
| EDEM1 | ER degradation enhancer, mannosidase alpha-like 1 | 3.13627 |
| IGF2BP2 | insulin-like growth factor 2 mRNA binding protein 2 | 2.93101 |
| MYC | v-myc avian myelocytomatosis viral oncogene homolog | 2.87075 |
| ABCC5 | ATP-binding cassette, sub-family C (CFTR/MRP), member 5 | 2.86821 |
| HMGA2 | high mobility group AT-hook 2 | 2.84175 |
| FHL2 | four and a half LIM domains 2 | 2.70654 |
| PIGP | phosphatidylinositol glycan anchor biosynthesis, class P | 2.63624 |
| USP24 | ubiquitin specific peptidase 24 | 2.63568 |
| CXCL2 | chemokine (C-X-C motif) ligand 2 | 2.48842 |
| TNIP1 | TNFAIP3 interacting protein 1 | 2.45481 |
| SLC75A1 | solute carrier family 75 member 1 | 2.43983 |
| EIF4EBP3 | eukaryotic translation initiation factor 4E binding protein 3 | 2.34562 |
| DZIP1 | DAZ interacting zinc finger protein 1 | 2.29891 |
| CDCA4 | cell division cycle associated 4 | 2.25221 |
| AHNAK2 | AHNAK nucleoprotein 2 | 2.23546 |
| TBPL1 | TBP-like 1 | 2.21749 |
| P4HA2 | prolyl 4-hydroxylase, alpha polypeptide II | 2.21687 |
| ARAP3 | ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3 | 2.20467 |
| KIFBP | kinesin family binding protein | 2.19103 |
| CETN3 | centrin, EF-hand protein, 3 | 2.18532 |
| SLC41A3 | solute carrier family 41, member 3 | 2.17389 |
| PTPRE | protein tyrosine phosphatase, receptor type, E | 2.13675 |
| TSPAN4 | tetraspanin 4 | 2.13458 |
| DCUN1D4 | DCN1, defective in cullin neddylation 1, domain containing 4 | 2.11686 |
| SSBP2 | single-stranded DNA binding protein 2 | 2.08677 |
| SPRY2 | sprouty homolog 2 (Drosophila) | 2.06401 |
| PDGFA | platelet-derived growth factor alpha polypeptide | 2.0235 |
| HSD17B8 | hydroxysteroid (17-beta) dehydrogenase 8 | 2.01772 |
| Symbol | Name | Standardized Value |
|---|---|---|
| HAT1 | histone acetyltransferase 1 | -7.06986 |
| PMM2 | phosphomannomutase 2 | -4.9262 |
| DNAJA3 | DnaJ (Hsp40) homolog, subfamily A, member 3 | -4.03941 |
| CLPX | caseinolytic mitochondrial matrix peptidase chaperone subunit | -3.91847 |
| CCNB1 | cyclin B1 | -3.52858 |
| STAP2 | signal transducing adaptor family member 2 | -3.32609 |
| HMG20B | high mobility group 20B | -3.06723 |
| PRR15L | proline rich 15-like | -2.85222 |
| TMEM186 | transmembrane protein 186 | -2.74946 |
| KRT14 | keratin 14, type I | -2.69921 |
| TRIB3 | tribbles pseudokinase 3 | -2.69231 |
| INSIG1 | insulin induced gene 1 | -2.56067 |
| DDIT4 | DNA-damage-inducible transcript 4 | -2.51646 |
| DNAJC7 | DnaJ (Hsp40) homolog, subfamily C, member 7 | -2.49333 |
| ELOVL6 | ELOVL fatty acid elongase 6 | -2.42231 |
| ITGAE | integrin, alpha E (antigen CD103, human mucosal lymphocyte antigen 1; alpha polypeptide) | -2.41722 |
| ECSIT | ECSIT signalling integrator | -2.38988 |
| IFI30 | interferon, gamma-inducible protein 30 | -2.35954 |
| CCNC | cyclin C | -2.34858 |
| SNRPA1 | small nuclear ribonucleoprotein polypeptide A' | -2.34395 |
| ANKRD10 | ankyrin repeat domain 10 | -2.24801 |
| ALDOC | aldolase C, fructose-bisphosphate | -2.23154 |
| CLDN7 | claudin 7 | -2.20883 |
| SNX2 | sorting nexin 2 | -2.20086 |
| SLC25A2 | solute carrier family 25 (mitochondrial carrier; ornithine transporter) member 2 | -2.18363 |
| TUBA4A | tubulin, alpha 4a | -2.18216 |
| TIMM44 | translocase of inner mitochondrial membrane 44 homolog (yeast) | -2.17581 |
| CARS1 | cysteinyl-tRNA synthetase 1 | -2.14364 |
| STIP1 | stress-induced phosphoprotein 1 | -2.09754 |
| INTS12 | integrator complex subunit 12 | -2.08545 |
| HERC6 | HECT and RLD domain containing E3 ubiquitin protein ligase family member 6 | -2.07727 |
| RAB17 | RAB17, member RAS oncogene family | -2.06266 |
| HSPB1 | heat shock 27kDa protein 1 | -2.05704 |
| SESN1 | sestrin 1 | -2.05322 |
| DDX23 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 23 | -2.04868 |
| BRMS1L | breast cancer metastasis-suppressor 1-like | -2.04373 |
| NRBP1 | nuclear receptor binding protein 1 | -2.0293 |
| MLLT11 | myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 11 | -2.02432 |
| H2BC12 | H2B clustered histone 12 | -2.02021 |
| METTL22 | methyltransferase like 22 | -2.01492 |
