CRCGN017_MCF10A.TP53.M_24H:G19 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylene chloride 98.8 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

47 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G19 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
SLC37A4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 4.47147
KIF5C kinesin family member 5C 3.98295
FGFR4 fibroblast growth factor receptor 4 3.57986
CCNF cyclin F 2.98804
LGMN legumain 2.90941
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.69811
CLNS1A chloride channel, nucleotide-sensitive, 1A 2.52168
ARID5B AT rich interactive domain 5B (MRF1-like) 2.4979
TBX2 T-box 2 2.48759
VIL1 villin 1 2.3646
MORF4L1 mortality factor 4 like 1 2.35873
OLFML2B olfactomedin-like 2B 2.32251
AAMDC adipogenesis associated, Mth938 domain containing 2.30984
SYNGR3 synaptogyrin 3 2.15271
CNRIP1 cannabinoid receptor interacting protein 1 2.13363
ZNF451 zinc finger protein 451 2.12795
DDC dopa decarboxylase (aromatic L-amino acid decarboxylase) 2.02479
ARSL arylsulfatase L 2.01614
CALML4 calmodulin-like 4 2.01461
N4BP2L1 NEDD4 binding protein 2-like 1 2.01297
MORC3 MORC family CW-type zinc finger 3 2.00333
TRAPPC4 trafficking protein particle complex 4 2.00292

decreased expression

Symbol Name Standardized Value
GDF15 growth differentiation factor 15 -5.56448
HMG20B high mobility group 20B -4.91824
TXNDC9 thioredoxin domain containing 9 -4.48402
CNDP2 CNDP dipeptidase 2 (metallopeptidase M20 family) -3.68246
CRK v-crk avian sarcoma virus CT10 oncogene homolog -2.5766
POLR2I polymerase (RNA) II (DNA directed) polypeptide I, 14.5kDa -2.51566
TENT4A terminal nucleotidyltransferase 4A -2.50119
C2CD5 C2 calcium-dependent domain containing 5 -2.49101
SGTA small glutamine-rich tetratricopeptide repeat (TPR)-containing, alpha -2.40665
UBE2Q1 ubiquitin-conjugating enzyme E2Q family member 1 -2.34855
CHST10 carbohydrate sulfotransferase 10 -2.292
UNKL unkempt family zinc finger-like -2.22196
CANT1 calcium activated nucleotidase 1 -2.20043
ZCCHC2 zinc finger, CCHC domain containing 2 -2.16645
EMC3 ER membrane protein complex subunit 3 -2.12609
TBCB tubulin folding cofactor B -2.1232
TLE5 TLE family member 5, transcriptional modulator -2.09473
KLF13 Kruppel-like factor 13 -2.09134
IMP4 IMP4, U3 small nucleolar ribonucleoprotein -2.07475
CDC34 cell division cycle 34 -2.05607
TBC1D8 TBC1 domain family, member 8 (with GRAM domain) -2.04829
CITED1 Cbp/p300-interacting transactivator, with Glu/Asp-rich carboxy-terminal domain, 1 -2.04132
SLC16A6 solute carrier family 16, member 6 -2.03989
MZT2A mitotic spindle organizing protein 2A -2.01894
SQSTM1 sequestosome 1 -2.01208