CRCGN017_MCF10A.TP53.M_24H:G21 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description methylene chloride 10.98 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

39 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G21 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
HMOX1 heme oxygenase 1 6.97942
RBP4 retinol binding protein 4, plasma 4.93985
MAMLD1 mastermind-like domain containing 1 4.87674
ABHD6 abhydrolase domain containing 6 4.5099
KLHL21 kelch-like family member 21 4.42179
RPL39L ribosomal protein L39-like 4.37176
ADAM10 ADAM metallopeptidase domain 10 4.12425
CERK ceramide kinase 3.82792
KIF5C kinesin family member 5C 3.68589
HBA1 hemoglobin, alpha 1 3.17463
ACLY ATP citrate lyase 2.72355
CNPY3 canopy FGF signaling regulator 3 2.70293
MARCHF1 membrane associated ring-CH-type finger 1 2.5828
VWA1 von Willebrand factor A domain containing 1 2.48835
CD3D CD3d molecule, delta (CD3-TCR complex) 2.36879
GZMA granzyme A (granzyme 1, cytotoxic T-lymphocyte-associated serine esterase 3) 2.26291
IL10RA interleukin 10 receptor, alpha 2.02979
NOL9 nucleolar protein 9 2.02433
ZDHHC4 zinc finger, DHHC-type containing 4 2.01487

decreased expression

Symbol Name Standardized Value
BASP1 brain abundant, membrane attached signal protein 1 -5.5233
HMG20B high mobility group 20B -5.33239
MRPS2 mitochondrial ribosomal protein S2 -4.82046
CD58 CD58 molecule -3.5899
CLPX caseinolytic mitochondrial matrix peptidase chaperone subunit -3.18215
SCYL3 SCY1-like 3 (S. cerevisiae) -2.99646
GDF15 growth differentiation factor 15 -2.9271
HSPA1A heat shock 70kDa protein 1A -2.81017
DNM1L dynamin 1-like -2.63332
PAEP progestagen-associated endometrial protein -2.57161
ENOX1 ecto-NOX disulfide-thiol exchanger 1 -2.55991
TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila) -2.51739
KDM3A lysine (K)-specific demethylase 3A -2.46803
ANKRD10 ankyrin repeat domain 10 -2.38783
KBTBD11 kelch repeat and BTB (POZ) domain containing 11 -2.20248
SEC16A SEC16 homolog A (S. cerevisiae) -2.19802
PPP1R26 protein phosphatase 1, regulatory subunit 26 -2.16584
TRIB3 tribbles pseudokinase 3 -2.12362
PLCB4 phospholipase C, beta 4 -2.11969
SPATA20 spermatogenesis associated 20 -2.00404