CRCGN017_MCF10A.TP53.M_24H:G22 Gene Set

Dataset Carcinogenome Chemical Perturbation Carcinogenicity Signatures
Category transcriptomics
Type small molecule perturbation
Description 4-(methylnitrosamino)-1-(3-pyri?dyl)-1-butanol 98.14 um perturbation at 24 h in MCF10A.TP53.M (Carcinogenome)
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Genes

23 genes differentially expressed following the CRCGN017_MCF10A.TP53.M_24H:G22 small molecule perturbation from the Carcinogenome Chemical Perturbation Carcinogenicity Signatures dataset.

increased expression

Symbol Name Standardized Value
MYL9 myosin, light chain 9, regulatory 3.7824
STIMATE STIM activating enhancer 3.44522
TBX2 T-box 2 2.41729
WASHC5 WASH complex subunit 5 2.16298
RPS6KA1 ribosomal protein S6 kinase, 90kDa, polypeptide 1 2.07554
PDLIM1 PDZ and LIM domain 1 2.06199
MMP1 matrix metallopeptidase 1 2.01018

decreased expression

Symbol Name Standardized Value
THAP11 THAP domain containing 11 -4.74604
KIF14 kinesin family member 14 -4.5496
SCYL3 SCY1-like 3 (S. cerevisiae) -4.29465
PPP2R5E protein phosphatase 2, regulatory subunit B', epsilon isoform -3.94319
CRK v-crk avian sarcoma virus CT10 oncogene homolog -3.35455
ANXA2 annexin A2 -2.95731
RXYLT1 ribitol xylosyltransferase 1 -2.93277
NUSAP1 nucleolar and spindle associated protein 1 -2.7452
PCCB propionyl CoA carboxylase, beta polypeptide -2.28997
POLG2 polymerase (DNA directed), gamma 2, accessory subunit -2.21745
NUBPL nucleotide binding protein-like -2.20006
MSMO1 methylsterol monooxygenase 1 -2.18515
HMGCS1 3-hydroxy-3-methylglutaryl-CoA synthase 1 (soluble) -2.13001
TEX10 testis expressed 10 -2.11301
ODR4 odr-4 GPCR localization factor homolog -2.1015
KIF3B kinesin family member 3B -2.06826